[1]潘云虎,季志宇,刘国生,等.苏黄止咳胶囊对减轻肺炎支原体肺部感染大鼠炎症反应的作用及机制探讨[J].福建医药杂志,2021,43(01):124-126.
点击复制

苏黄止咳胶囊对减轻肺炎支原体肺部感染大鼠炎症反应的作用及机制探讨()
分享到：

《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期数:
2021年01期
页码:
124-126
栏目:
基础研究
出版日期:
2021-02-10

文章信息/Info

文章编号:
1002-2600(2021)01-0124-03
作者:
潘云虎; 季志宇; 刘国生; 李发根; 陈艺坛
联勤保障部队第九O七医院(南平 353000)
关键词:
肺炎支原体;  苏黄止咳胶囊;  TGF-β;  KL-6;  SP-D
分类号:
R563.1
文献标志码:
B
摘要:
目的 探讨苏黄止咳胶囊在肺炎支原体肺部感染大鼠中的作用及相关机制。方法 将雄性SD大鼠随机分为5组,分别为正常对照组、肺炎支原体肺部感染组和肺炎支原体肺部感染苏黄止咳胶囊不同剂量组(低剂量组,3.5 g/kg; 中等剂量组7 g/kg; 高剂量组14 g/kg)。肺炎支原体肺部感染大鼠模型通过在24周内反复9次经超声雾化吸入肺炎支原体构建。各组给予留取大鼠肺泡灌洗液进行细胞计数分析及TGF-β、KL-6和SP-D浓度检测。结果 肺炎支原体肺部感染各组大鼠肺泡灌洗液中巨噬细胞计数、中性粒细胞计数及TGF-β、KL-6和SP-D 浓度明显高于正常对照组(P<0.05),在苏黄止咳胶囊中等剂量及高剂量治疗组,巨噬细胞计数及中性粒细胞计数及3种细胞因子水平明显低于未治疗组(P<0.05)。结论 苏黄止咳胶囊可以通过抑制TGF-β、KL-6和SP-D水平从而减轻肺炎支原体所致大鼠肺部炎症反应,可能在肺炎支原体感染中有一定的临床应用价值。

参考文献/References:

[1] Totten A H,Xiao L,Luo D, et al.Allergic airway sensitiza-tion impairs antibacterial IgG antibody responses during bacterial respiratory tract infections[J]. J Allergy Clin,Immunol,2019,143(3):1183-1197.
[2] Marchello C.Prevalence of atypical pathogens in patients with cough and CAP: a meta-analysis[J]. Ann Fam Med, 2016,14(6):552-566.
[3] Wang J,Sun R,Wang R, et al.A traditional Chinese patent medicine-Suhuang zhike capsule for cough variant asthma in adults: a protocol of systematic review and meta-analysis of randomized controlled trials[J]. Medicine(Baltimore),2019,98(50):18335.
[4] 邱容,肖昌武,文富强.布地奈德福莫特罗联合苏黄止咳胶囊对咳嗽变异性哮喘的疗效观察[J]. 临床肺科杂志,2017,22(2):304-306.
[5] Kumar S.Mycoplasma pneumoniae: a significant but underrated pathogen in paediatric community-acquired lower respiratory tract infections[J],2018,147(1):23-31.
[6] Waites K B,Talkington D F.Mycoplasma pneumoniae and its role as a human pathogen[J]. Clinical Microbiology Reviews,2004,17(4):697-728.
[7] Byrne A J,Mathie S A.Pulmonary macrophages: key players in the innate defence of the airways[J]. Thorax,2015,70(12): 1189-1196.
[8] Makinde T, Murphy R F,Agrawal D K.The regulatory role of TGF-beta in airway remodeling in asthma[J]. Immunol Cell Biol,2007, 85(5):348-356.
[9] Newman V, Gonzalez R F, Matthay M A, et al.A novel alveolar type I cell-specific biochemical marker of human acute lung injury[J]. Am J Respir Crit Care Med,2000, 161(3pt1): 990-995.
[10] Todd D A, Marsh M J, George A, et al.Surfactant phospholipids, surfactant proteins, and inflammatory markers during acute lung injury in children[J]. Pediatr Crit Care Med,2010,11(1): 82-91.
[11] Daimon T, Tajima S, Oshikawa K, et al.KL-6 and surfactant proteins A and D in serum and bronchoalveolar lavage fluid in patients with acute eosinophilic pneumonia[J]. Intern Med, 2005, 44(8): 811-817.
[12] Yang J.Observation of the effects of the Suhuang Zhike capsule on acute bronchitis[J]. J Biol Regul Homeost Agents,2017,31(2):453-457.

相似文献/References:

[1]郭晓峰,朱鹏举,王程毅,等.儿童重症肺炎支原体肺炎185例影响因素分析[J].福建医药杂志,2021,43(06):1.
　GUO Xiaofeng,ZHU Pengju,WANG Chengyi,et al.Analysis of influencing factors of 185 children with severe mycoplasma pneumoniae pneumonia[J].FUJIAN MEDICAL JOURNAL,2021,43(01):1.

备注/Memo

备注/Memo:
基金项目:2014年度军区医学科技创新课题项目(14ZD32)
更新日期/Last Update: 2021-02-10