[1]杨辉,张东元,张青铃,等.葛明胶囊防潮辅料的优选研究[J].福建医药杂志,2022,44(02):119-123.
　YANG Hui,ZHANG Dongyuan,ZHANG Qingling,et al.Study on optimum selection of moisture-proof excipients for Geming Capsules[J].FUJIAN MEDICAL JOURNAL,2022,44(02):119-123.
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葛明胶囊防潮辅料的优选研究()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期数:
2022年02期
页码:
119-123
栏目:
基础研究
出版日期:
2022-04-15

文章信息/Info

Title:
Study on optimum selection of moisture-proof excipients for Geming Capsules
文章编号:
1002-2600(2022)02-0119-05
作者:
杨辉; 张东元1; 张青铃1; 罗友华2; 刘晓娟; 许光辉; 黄亦琦
厦门市健康医疗大数据中心 厦门市医药研究所 厦门市天然药物研究与开发重点实验室(厦门 361008)
Author(s):
YANG Hui;  ZHANG Dongyuan;  ZHANG Qingling;  LUO Youhua;  LIU Xiaojuan;  XU Guanghui;  HUANG Yiqi
Xiamen Key Laboratory of Natural Medicine Research and Development, Xiamen Medicine Institute, Xiamen Health and Medical Big Data Center, Xiamen, Fujian 361008, China
关键词:
葛明胶囊;  防潮辅料;  优选;  吸湿动力学曲线;  吸湿等温曲线下面积
Keywords:
Geming Capsules;  moisture-proof excipients;  optimize;  hygroscopic dynamics curve;  area under the hygroscopic isothermal curve
分类号:
R944
文献标志码:
B
摘要:
目的 优选葛明胶囊的防潮辅料。方法 以称重法测定含辅料葛明胶囊浸膏粉(HFLJGF)在25 ℃ 不同相对湿度(RH)下120 h内每隔24 h的含水率。应用orignPro8软件,以残差平方和(RSS)、相关系数(R2)、赤池信息准则(AIC)为指标,优选HFLJGF吸湿等温和吸湿动力学曲线模型; 以吸湿等温曲线下面积(AUHIC)优选葛明胶囊的防潮辅料。结果 18种HFLJGF在不同RH下放120 h的含水率为0.17%～47.52%。HFLJGF的最优吸湿动力学曲线为SWeibull2和双指数模型,吸湿等温曲线均为Peleg模型。18个HFLJGF中,AUHIC最小的防潮辅料为山嵛酸甘油酯。结论 葛明胶囊的最优防潮辅料为山嵛酸甘油酯,AUHIC可数字化表征和定量评价药物吸湿性强弱,为中药制剂防潮辅料优选提供参考。
Abstract:
Objective To optimize the moisture-proof excipients of Geming Capsules.Methods The moisture content of Geming Capsules extract powder with excipient(HFLJGF)was determined by weighing method at intervals of 24 h within 120 h at different relative humidity(RH)under 25 ℃.OrignPro8 software was used to optimize the models of the hygroscopic isothermal curve and the hygroscopic dynamics curve of Geming Capsules extract powder with expipients(HFLJGF), taking the sum of residual squares(RSS), the correlation coefficient(R2)and the akaike information criterion(AIC)as indicators.The area under the hygroscopic isothermal curve(AUHIC)was used to select the moisture-proof auxiliary material for Geming capsules.Results The moisture content of 18 kinds of HFLJGF under the different RH for 120 h ranged from 0.17% to 47.52%.The optimal mathematical model of hygroscopic dynamics curve of HFLJGF was SWeibull2 or double exponential model, and the hygroscopic isothermal curve was Peleg model.In the 18 HFLJGF,the smallest moisture-proof excipient of AUHIC was glyceryl behenate.Conclusion Glyceryl behenate is the best moisture proof excipient for Geming Capsules, and AUHIC can digitally characterize and evaluate the hygroscopicity of drugs, providing reference for the selection of moisture-proof excicients for traditional Chinese medicine preparations.

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备注/Memo

备注/Memo:
基金项目:厦门市医疗卫生指导性项目(3502Z20209258)
1 福建中医药大学药学院; 2 通信作者:Email:youhualuo@163.com
更新日期/Last Update: 2022-04-15