[1]熊红萍 徐 静 周 强 吴埼淇 甘国翔 陈忠山.盐酸小檗碱对糖尿病患者血糖、胃肠激素及肠道菌群的影响[J].福建医药杂志,2019,41(01):6-9.
　XIONG Hongping,XV Jing,ZHOU Qiang,et al.Effect of berberine on blood glucose,gastrointestinal hormones and intestinal flora of diabetic patients[J].FUJIAN MEDICAL JOURNAL,2019,41(01):6-9.
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盐酸小檗碱对糖尿病患者血糖、胃肠激素及肠道菌群的影响()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
41
期数:
2019年01期
页码:
6-9
栏目:
临床研究
出版日期:
2019-01-20

文章信息/Info

Title:
Effect of berberine on blood glucose,gastrointestinal hormones and intestinal flora of diabetic patients
文章编号:
1002-2600(2019)01-0006-04
作者:
熊红萍 徐 静 周 强 吴埼淇1 甘国翔2 陈忠山2
厦门大学附属福州第二医院内分泌科(福州 350007)
Author(s):
XIONG Hongping; XV Jing; ZHOU Qiang; WU Qiqi; GAN Guoxiang; CHEN Zhongshan.
Department of Endocrinology,the Affiliated Fuzhou Municipal Second Hospital, Xiamen University,Fuzhou, Fujian 350007, China
关键词:
糖尿病;  胃泌素;  胰高血糖素;  肠道菌群
Keywords:
diabetes mellitus;  gastrin;  glucagon;  enterobacteria
分类号:
R587.1
文献标志码:
B
摘要:
目的 探讨盐酸小檗碱对2型糖尿病患者胃泌素、胰高血糖素及肠道菌群的影响。方法 选择我院单用胰岛素治疗的2型糖尿病患者25例为治疗组,选取同期体检中心体检健康人群10例为对照组。治疗组根据血糖情况调整胰岛素剂量,同时给予盐酸小檗碱每次500 mg,tid,连续12周。分别于0、4、8、12周检测血糖、胃泌素、胰高血糖素,于0、12周采集清晨空腹粪便进行粪便菌群培养。结果 治疗组治疗前后胃泌素水平均明显高于对照组(P<0.01); 治疗组治疗后胃泌素水平高于0周水平(P<0.01)。治疗组治疗前后胰高血糖素明显高于对照组(P<0.01),治疗前后差异无统计学意义(P>0.05)。治疗组治疗前厚壁菌门高于治疗后及对照组水平(P<0.05); 治疗组治疗前乳酸杆菌属、拟杆菌属明显低于治疗后水平(P<0.05); 治疗组治疗前拟杆菌属、柔嫩梭菌属低于对照组水平(P<0.05)。结论 2型糖尿病患者存在胃肠激素及肠道菌群失调,盐酸小檗碱有助于改善糖尿病患者胃肠激素、肠道菌群失调现象。
Abstract:
Objective To explore the effect of berberine on gastrin(GAS), glucagon(GLC)and intestinal flora of type 2 diabetes mellitus(T2DM). Methods The T2DM patients with insulin were taken as the treatment group, while other ten healthy people were taken as the control group.The T2DM patients received adjustive insulin dose treatments according to the blood glucose condition with berberine(500 mg,tid)for twelve weeks.The level of their blood glucose, GAS, GLC were tested at 0,4,8,12 week respectively.In addition, the faeces were collected to breed fecal flora at 0,12 week. Results The GAS of treatment group was significantly higher than that of the control group(P<0.01), which was higher than that in 0 week(P<0.01).After treatment,the glucagon of treatment group was significantly higher than that of the control group(P<0.01).The firmicutes of treatment group declined(P<0.05), while the lactobacillus and bacteroides increased(P<0.05). The bacteroides and clostridium leptum of treatment group were lower than those of the control group(P<0.05).Conclusion The T2DM patients have gastrointestinal hormones and intestinal flora disorders, berberine has an effect on them.

参考文献/References:

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[2] Suarez-Pinzon W L, Lakey J R T, Brand S J, et al. Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass[J]. Journal of Clinical Endocrinology & Metabolism, 2005, 90(6):3401-3409.
[3] Larsson H,Ahrén B.Islet disfunction in insulin resistance involves impaired insulin secretion and increased glucagon secretion in postmenopausal women with impaired glucose tolerance[J].Diabetes Care,2000,23(5):650-657.
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备注/Memo

备注/Memo:
基金项目:福州市卫生计生系统科技计划项目(2015-S-wt2); 福建省中青年骨干科技计划项目(2015-ZQN-JC-37)1 厦门大学; 2 福建中医药大学
更新日期/Last Update: 2019-01-20