[1]许雪峰,陈彦,赵洁馨,等.幽门螺杆菌感染与非酒精性脂肪性肝病的关系探讨[J].福建医药杂志,2022,44(04):8-11.
　XU Xuefeng,CHEN Yan,ZHAO Jiexin,et al.Relationship between Helicobacter pylori infection and nonalcoholic fatty liver disease[J].FUJIAN MEDICAL JOURNAL,2022,44(04):8-11.
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幽门螺杆菌感染与非酒精性脂肪性肝病的关系探讨()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期数:
2022年04期
页码:
8-11
栏目:
临床研究
出版日期:
2022-08-15

文章信息/Info

Title:
Relationship between Helicobacter pylori infection and nonalcoholic fatty liver disease
文章编号:
1002-2600(2022)04-0008-04
作者:
许雪峰; 陈彦1; 赵洁馨2; 郑承超3; 林雄峰4; 吴芳梅; 黄艳芳; 黄雪梅; 郑铭2; 5
福建医科大学省立临床医学院 福建省立医院消化内科(福州 350001)
Author(s):
XU Xuefeng;  CHEN Yan;  ZHAO Jiexin;  ZHEN Chenchao;  LIN Xiongfeng;  WU Fangmei;  HUANG Yanfang;  HUANG Xuemei;  ZHENG Ming
Department of Medical Gastroenterology, Fujian Provincial Hospital, Fuzhou, Fujian 350001, China
关键词:
幽门螺杆菌; 非酒精性脂肪性肝病; 糖尿病; 低密度脂蛋白胆固醇
Keywords:
helicobacter pylori;  nonalcoholic fatty liver disease;  diabetes mellitus;  low-density lipoprotein cholesterol
分类号:
R575.5
文献标志码:
A
摘要:
目的 探讨幽门螺杆菌(Hp)感染与非酒精性脂肪性肝病(NAFLD)的关系。方法 收集我院行快速尿素酶试验同时行腹部超声检查的住院患者共920例,根据有无合并NAFLD,分为NAFLD组及对照组,通过二元logistic回归分析Hp感染与NAFLD的关系。结果 总研究对象中,NAFLD组(387例)Hp阳性者为98例,对照组(533例)Hp阳性者为119例,NAFLD组Hp感染率较对照组高(25.3% vs 22.3%),但两组Hp感染率差异无统计学意义(P=0.291); 但在DM人群中,NAFLD组(94例)Hp阳性者27例,对照组(61例)Hp阳性者9例,NAFLD组较对照组Hp感染率高(28.7% vs 14.8%),且两组差异有统计学意义(χ2=4.048,P=0.048)。在调整除TC、LDL-C、HDL-C等3个血脂指标之外的其他因素后,二元logistic回归分析仍显示两组Hp感染率差异有统计学意义(P=0.030)。而在调整上述3个血脂指标后,两组Hp感染率差异无统计学意义(P=0.215)。另该3个血脂指标中只发现LDL-C与NAFLD存在关联(P=0.000)。结论 DM患者Hp感染与NAFLD存在关联,且两者之间的关联可能是通过LDL-C介导。
Abstract:
Objective To investigate the relationship between Helicobacter pylori(Hp)infection and Nonalcoholic fatty liver disease(NAFLD). Methods A total of 920 inpatients who underwent rapid urease test and abdominal ultrasonography were collected.According to the presence or absence of NAFLD, they were divided into NAFLD group and control group.Logistic regression analysis was used to study the relationship between Hp infection and NAFLD.Results Among the total study subjects, 98 cases were Hp positive in the NAFLD group(387 cases), and 119 cases were Hp positive in the control group(533 cases).There was no significant difference in the Hp infection rate between the two groups(P=0.291); but in the DM population, 27 cases were Hp positive in the NAFLD group(94 cases), and 9 cases were Hp positive in the control group(61 cases).The infection rate of H.pylori in the NAFLD group was higher than that in the control group(28.7% vs 14.8%), and the difference between the two groups was statistically significant(χ2=4.048,P=0.048).After adjusting for other factors except cholesterol(TC), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C), the Hp infection rate between the two groups was statistically significant(P=0.030).After adjusting the above three blood lipid indexes, there was no statistical significance in the difference of Hp infection rate between the two groups(P=0.215).In the other three blood lipid indexes, only LDL-C and NAFLD were found to be correlated(P=0.000). Conclusion There is an association between Hp infection and NAFLD in DM patients, and the association between the two may be mediated by LDL-C.

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备注/Memo

备注/Memo:
基金项目:福建省科技计划社会发展引导性(重点)项目(2019Y0056)
1 福建省立金山医院内科; 2 干部特诊科; 3 福建省老年医院消化内科; 4 福建省立金山医院内镜中心; 5 通信作者,Email:yuan970936@sina.com
更新日期/Last Update: 2022-08-15