[1]廖小文,潘丁龙,吴敏,等.Mobocertinib治疗非小细胞肺癌的药理学研究[J].福建医药杂志,2024,46(01):125-127133.[doi:10.20148/j.fmj.2024.01.034]
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Mobocertinib治疗非小细胞肺癌的药理学研究()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期数:
2024年01期
页码:
125-127133
栏目:
综述与讲座
出版日期:
2024-02-15

文章信息/Info

文章编号:
1002-2600(2024)01-0125-04
作者:
廖小文1潘丁龙1吴敏1陈国忠1综述张吟2审校
1 福建医科大学附属第二医院肿瘤放射治疗科,泉州 362000;2 福建医科大学附属第二医院药学部,泉州 362000
关键词:
小细胞肺癌Mobocertinib药理学EGFR20号外显子插入突变跨膜受体酪氨酸激酶抑制剂
分类号:
R734.2
DOI:
10.20148/j.fmj.2024.01.034
文献标志码:
B
摘要:
肺癌是全球常见的恶性肿瘤之一,包括非小细胞肺癌和小细胞肺癌两种病理类型,其中,对于部分晚期非小细胞肺癌患者存在有意义的突变靶点,可首选靶向药物治疗。EGFR20号外显子插入(exon 20 insertion,ex20ins)突变是非小细胞肺癌罕见突变,通常对现有的靶向药物耐药,目前缺乏有效的靶向治疗药物。Mobocertinib是一种靶向EGFR ex20ins的新型小分子口服药物,2021年9月15日经美国FDA批准上市用于具有EGFR ex20ins突变的局部晚期或转移性NSCLC成年患者的治疗。本文对该药物的作用机制、药物效应动力学、药物代谢动力学、临床疗效及安全性等方面进行综述总结,为临床使用该药提供一定的参考。

参考文献/References:

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更新日期/Last Update: 2024-02-15