[1]孙伏清,周密,周晓兰,等.前纤维蛋白-1浓度与冠心病患者PCI术后2年患者发生主要不良心血管事件的关系[J].福建医药杂志,2022,44(04):17-19.
　SUN Fuqing,ZHOU Mi,ZHOU Xiaolan,et al.Association between baseline serum profilin-1 concentration and major adverse cardiovascular events in 2-year patients after percutaneous coronary intervention[J].FUJIAN MEDICAL JOURNAL,2022,44(04):17-19.
点击复制

前纤维蛋白-1浓度与冠心病患者PCI术后2年患者发生主要不良心血管事件的关系()
分享到：

《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期数:
2022年04期
页码:
17-19
栏目:
临床研究
出版日期:
2022-08-15

文章信息/Info

Title:
Association between baseline serum profilin-1 concentration and major adverse cardiovascular events in 2-year patients after percutaneous coronary intervention
文章编号:
1002-2600(2022)04-0017-03
作者:
孙伏清; 周密; 周晓兰; 林永芳; 郭城; 林凯金; 陈平
福建医科大学附属福清市医院 福建省福清市医院心血管内科(福清 350300)
Author(s):
SUN Fuqing;  ZHOU Mi;  ZHOU Xiaolan;  LIN Yongfang;  GUO Cheng;  LIN Kaijin;  CHEN Ping
Department of Cardiology, Fuqing Municipal Hospital, Fuqing Municipal Hospital Affiliated to Fujian Medical University, Fuqing, Fujian 350300,China
关键词:
冠心病; 前纤维蛋白-1; 心血管事件
Keywords:
coronary heart disease;  profilin-1;  cardiovascular events
分类号:
R541.4; R540.4+6
文献标志码:
B
摘要:
目的 探讨前纤维蛋白-1(Profilin-1)浓度与冠心病患者经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后2年发生心血管事件的相关性。方法 本研究纳入772例冠心病患者PCI术后患者进行为期2年随访。根据患者是否发生不良心血管事件,将患者分为A组(67例发生不良心血管事件)和B组(705例未发生不良心血管事件)。同时评估Profilin-1对PCI术后的患者2年内发生不良心血管事件的预测价值。结果 冠心病患者随访2年发生心血管事件率与Profilin-1浓度,与B组比较,A组Profilin-1更高[133.85(110.09～157.55)ng/mL],差异均有统计学意义(P<0.01)。对PCI术后患者2年内并发不良心血管事件的预测价值中,ROC曲线下面积为0.821[95%可信区间(0.762,0.81),P<0.01]。并且ROC曲线分析中建立的临界值基础上,将血清Profilin-1浓度分为高危组(≥120.205 ng/mL)和低危组(<120.205 ng/mL)。根据Kaplan-Meier生存曲线所示,血清Profilin-1浓度高危组较低危组的患者心血管事件的发生率明显升高。结论 Profilin-1浓度在一定程度上可预测2年心血管事件发生。
Abstract:
Objective To investigate the levels of profilin-1 concentrations associated with 2-year major adverse cardiovascular events in patients after percutaneous coronary intervention.Methods A total of 772 patients who had been followed up for two years were enrolled in this study.Depending on whether the patients had adverse cardiovascular events, the patients were divided into Group A(67 cases with adverse ardiovascular events)and Group B(705 cases without adverse cardiovascular events).Profilin-1's predictive value was assessed in detecting 2-year major adverse cardiovascular events in patients after percutaneous coronary intervention.Results Compared with those without adverse cardiovascular events, patients with coronary heart disease who have been followed up for two years were detected higher levels of profilin-1 [133.85(110.09-157.55)ng/mL,P<0.01].For 2-year major adverse cardiovascular events in patients after percutaneous coronary intervention, the area under the curve was 0.786 by using ROC curve in predicting MACEs [95%CI(0.724-0.848), P<0.01)].ROC curve analysis was used to evaluate the optimal cut off values. Serums profilin-1 concentration was categorized into high(≥120.205 ng/mL)and low(<120.205 ng/mL)groups.According to the Kaplan-Meier survival curve, the incidence of cardiovascular events in patients with high risk group with serum profilin-1 concentration was significantly increased than those with low risk group.Conclusion The profilin-1 concentrations may predict 2-year major adverse cardiovascular events in patients after percutaneous coronary intervention.

参考文献/References:

[1] 王燕逍翔,白建军,宇传华.基于全球视角的中国心血管病疾病负担现状及趋势[J].公共卫生与预防医学,2021,32(06):6-11.
[2] Chen M S,John J M,Chew D P,et al.Bare metal stent restenosis is not a benign clinical entity[J].Am Heart J,2006,151(6):1260-1264.
[3] Carlsson L, Nyström L E, Sundkvist I, et al.Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells[J].J Mol Biol,1977,115(3):465-483.
[4] Caglayan E, Romeo G R, Kappert K,et al.Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells[J].PloS one,2010,5(10):e13608.
[5] 黎嘉雯,袁德山,苏淑红.血小板反应性对使用比伐卢定抗凝的择期经皮冠状动脉介入治疗患者临床事件的影响[J].中华心血管病杂志,2021,49(08):783-789.
[6] Giulio R,Romeo,Andrius,et al.Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1[J].The Journal of biological chemistry,2008,283(15):9595-9605.

相似文献/References:

[1]张健春 王新康.冠心病心律失常患者55例动态心电图与常规心电图对比分析[J].福建医药杂志,2018,40(06):68.
[2]黎 冉.阿托伐他汀钙干预对冠心病患者围术期心脏事件的影响[J].福建医药杂志,2020,42(01):26.
　LI Ran..Effect of atorvastatin calcium on perioperative cardiac events in patients with coronary heart disease[J].FUJIAN MEDICAL JOURNAL,2020,42(04):26.

备注/Memo

备注/Memo:
基金项目:2021年福州市卫生健康中青年科学研究项目(2021-S-wq36)
更新日期/Last Update: 2022-08-15