[1]程辉.基于数据挖掘分析G蛋白偶联受体116在弥漫大B细胞淋巴瘤中的表达及功能预测[J].福建医药杂志,2021,43(03):22-26.
　CHENG Hui.Analysis of GPR116 expression and function prediction in diffuse large B cell lymphoma based on data mining[J].FUJIAN MEDICAL JOURNAL,2021,43(03):22-26.
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基于数据挖掘分析G蛋白偶联受体116在弥漫大B细胞淋巴瘤中的表达及功能预测()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期数:
2021年03期
页码:
22-26
栏目:
临床研究
出版日期:
2021-06-15

文章信息/Info

Title:
Analysis of GPR116 expression and function prediction in diffuse large B cell lymphoma based on data mining
文章编号:
1002-2600(2021)03-0022-05
作者:
程辉
福建省立医院病理科(福州 350001)
Author(s):
CHENG Hui
Department of Pathology, Fujian Provincial Hospital, Fuzhou, Fujian 350001, China
关键词:
GPR116;  弥漫大B细胞淋巴瘤;  生物信息学;  预后
Keywords:
GPR116;  diffuse large B-cell lymphoma;  bioinformatics;  prognosis
分类号:
R733.4
文献标志码:
B
摘要:
目的 通过数据挖掘分析G蛋白偶联受体116(GPR116)在弥漫大B细胞淋巴瘤(DLBCL)中的表达及功能预测。方法 基于多个国际公认数据库中有关 GPR116的表达谱及临床数据,分析DLBCL中GPR116的表达情况、临床病理参数及生存预后的关系,并通过基因本体(GO)分析以及京都基因与基因组百科全书(KEGG)分析对GPR116进行功能注释及通路富集分析。结果 与正常对照相比,GPR116在DLBCL中的表达显著上调,其表达与DLBCL患者的年龄、性别、肿瘤分期等相关,与DLBCL患者预后不良有关。GPR116共表达基因主要参与细胞外结构、细胞外基质组成、血管形成调节及细胞基质黏附等过程,并显著富集于多个致癌信号通路、黏着斑途径、ECM-受体相互作用等相关通路。结论 GPR116在DLBCL中起癌基因的作用,可能是DLBCL的一个可靠的诊疗靶点。
Abstract:
Objective To analyze GPR116 expression and function prediction in diffuse large B cell lymphoma by data mining.Methods Based on the expression profiles and clinical data of GPR116 in several internationally recognized databases, we analyzed the expression of GPR116 and the relationship between clinicopathological parameters and survival prognosis.And we further predicted the possible biological function by GO and KEGG analysis.Results Compared with the control, GPR116 expression in DLBCL was significantly up-regulated, which was related to the age, gender, tumor stage of DLBCL, and the patients with high GPR116 expressions had poor prognosis.GPR116 co-expressed genes were mainly involved in the process of extracellular structure, extracellular matrix composition, vascular regulation and matrix adhesion, and were significantly enriched in multiple carcinogenic signaling pathways, focal adhesion, ECM-receptor interaction.Conclusion GPR116 plays a role of oncogene in DLBCL, which may be a reliable diagnosis and treatment target of DLBCL.

参考文献/References:

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更新日期/Last Update: 2021-06-15