[1]郑泽宇 综述 陈 刚 审校.2019-nCoV肺炎的研究现状与未来展望[J].福建医药杂志,2020,42(01):1-7.
　ZHENG Zeyu,CHEN Gang..Research status and future prospect of 2019-nCoV pneumonia[J].FUJIAN MEDICAL JOURNAL,2020,42(01):1-7.
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2019-nCoV肺炎的研究现状与未来展望()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期数:
2020年01期
页码:
1-7
栏目:
专题报告
出版日期:
2020-03-30

文章信息/Info

Title:
Research status and future prospect of 2019-nCoV pneumonia
文章编号:
1002-2600(2020)01-0001-07
作者:
郑泽宇 综述 陈 刚1 审校
福建医科大学省立临床医学院(福州 350001)
Author(s):
ZHENG Zeyu; CHEN Gang.
Provincial Clinical Medical College of Fujian Medical University,Fuzhou,Fujian 350001, China
关键词:
新型冠状病毒;  研究进展
Keywords:
novel coronavirus;  research progress
分类号:
R563.1
文献标志码:
A
摘要:
病毒或细菌引起的呼吸道感染是人类最常见的疾病之一,而由新型冠状病毒引起的呼吸道病毒感染,如最近在中国武汉引发肺炎爆发的新型冠状病毒(2019-nCoV)对我国公共卫生健康构成了威胁。这篇综述简要介绍了冠状病毒的基因结构、传播的多样性等特点,以及此次新型冠状病毒感染患者的临床表现和流行病学特征。这将有助我们了解此次新型冠状病毒肺炎,并对此次疫情的防控提供帮助。
Abstract:
Respiratory infections caused by viruses or bacteria are one of the most common diseases in humans, and respiratory virus infections caused by novel coronaviruses, such as the novel coronavirus 2019-nCoV, which recently caused a pneumonia outbreak in Wuhan, China,poses a threat to public health in China. In this review, the characteristics of the coronavirus gene structure, the diversity of spread, the clinical symptoms and epidemiological diagnosis of patients with this novel coronavirus infection were briefly reviewed. This review will help us to understand this novel coronavirus pneumonia and provide new directions for the prevention and control of its epidemic.

参考文献/References:

[1] Wang L F, Shi Z, Zhang S, et al. Review of bats and SARS[J]. Emerging infectious diseases, 2006, 12(12): 1834-1840.
[2] Chen Y,Guo D,Molecular mechanisms of coronavirus RNA capping and methylation[J].Virol Sin, 2016, 31(1): 3-11.
[3] Cui J,Li F,Shi Z L.Origin and evolution of pathogenic coronaviruses[J].Nat Rev Microbiol, 2019, 17(3): 181-192.
[4] Cauchemez S, Van Kerkhove M D, Riley S, et al. Transmission scenarios for Middle East Respiratory Syndrome Coronavirus(MERS-CoV)and how to tell them apart[J]. Euro surveill-ance: bulletin Europeen sur les maladies transmissibles=European communicable disease bulletin, 2013, 18(24).
[5] Zhong N S,Zheng B J,Li Y M, et al. Epidemiology and cause of severe acute respiratory syndrome(SARS)in Guangdong, Peoples Republic of China, in February, 2003[J].Lancet, 2003, 362(9393): 1353-1358.
[6] WHO. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003[EB/OL].[2020-01-12]. Geneva: World Health Organization, 2004.http://www.who.int/csr/sars/country/table2004_04_21/en/.
[7] WHO. Middle East respiratory syndrome coronavirus(MERS-CoV)[EB/OL]. Geneva:World Health Organization, 2020[2020-01-12]. http://www.who.int/emergencies/mers-cov/en/.
[8] Ziebuhr J,Snijder E J,Gorbalenya A E,Virus-encoded proteinases and proteolytic processing in the Nidovirales[J]. J Gen Virol, 2000, 81(4): 853-879.
[9] Hussain S,Pan J,ChenY,et al. Identification of novel subgenomic RNAs and noncanonical transcription initiation signals of severe acute respiratory syndrome coronavirus [J].J Virol, 2005, 79(9): 5288-5295.
[10] Zhu N, Zhang D, Wang W, et al.A Novel Coronavirus from Patients with Pneumonia in China, 2019[J]. New England Journal of Medicine, 2020.
[11] Fehr A R, Perlman S. Coronaviruses: an overview of their replication and pathogenesis[M]. New York: Humana Press, 2015: 1-23.
[12] Su S,Wong G,Shi W F,et al. Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses[J].Trends Microbiol,2016, 24(6): 490-502.
[13] Zhou P,Fan H,Lan T, et al. Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.[J].Nature, 2018, 556(7700): 255-258.
[14] Ji W,Wang W,Zhao X F,et al. Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human.[J] J Med Virol,2020.
[15] Shi Z L, Zhou P, Yang X L, et al. Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin[J]. bioRxiv, 2020.
[16] Chan J F W, Yuan S, Kok K H, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster[J]. The Lancet, 2020.
[17] Sabir J S M, Lam T T Y, Ahmed M MM, et al. Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia[J]. Science, 2016, 351(6268): 81-84.
[18] Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. The Lancet, 2020.
[19] Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019[J]. New England Journal of Medicine, 2020.
[20] Li Q,Guan X H,Wu P,et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia[J].N Engl J Med, 2020.
[21] Chen N,Zhou M,Dong X et al.Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study[J]. The Lancet, 2020.
[22] Wang C, Horby P W, Hayden F G, et al. A novel coronavirus outbreak of global health concern[J]. The Lancet, 2020.
[23] WHO.Clinical management of severe acute respiratory infection when Novel coronavirus(nCoV)infection is suspected: Interim Guidance:World Health Organization,2020[R/OL].[2020-01-12].https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf?sfvrsn=bc7da517-2.
[24] Heymann D L. Data sharing and outbreaks: best practice exemplified[J]. The Lancet, 2020.
[25] 李凯述,陈建荣,蔡映云.人工智能专家系统在呼吸系统疾病中的应用[J].国外医学内科学分册,2005,32(12):513-515,520.
[26] Su K,Xu L,Li G Q,et al. Forecasting influenza activity using self-adaptive AI model and multi-source data in Chongqing, China[J].EBioMedicine, 2019, 47: 284-292.
[27] Meinert E,Alturkistani A,Foley K A,et al. Blockchain Implementation in Health Care: Protocol for a Systematic Review[J].JMIR Res Protoc, 2019, 8(2): e10994.
[28] Sharma A, Kumar R. An optimal routing scheme for critical healthcare HTH services-an IOT perspective[C]//2017 Fourth International Conference on Image Information Processing(ICIIP). IEEE, 2017: 1-5.
[29] Engelhardt M A. Hitching healthcare to the chain: An introduction to blockchain technology in the healthcare sector[J]. Technology Innovation Management Review, 2017, 7(10).
[30] Saravanan M, Shubha R, Marks A M, et al. SMEAD: A secured mobile enabled assisting device for diabetics monitoring[C].2017 IEEE International Conference on Advanced Networks and Telecommunications Systems(ANTS). IEEE, 2017: 1-6.
[31] Chattu V K, Nanda A, Chattu S K, et al. The emerging role of blockchain technology applications in routine disease surveillance systems to strengthen global health security[J]. Big Data and Cognitive Computing, 2019, 3(2): 25.
[32] Katuwal G J, Pandey S, Hennessey M, et al. Applications of blockchain in healthcare: current landscape & challenges[J]. arXiv preprint arXiv:1812.02776, 2018.
[33] World Health Organization. Infection prevention and control during health care when novel coronavirus(nCoV)infection is suspected: interim guidance, January 2020[R]. World Health Organization, 2020.
[34] Wong C K, Lam C W K, Wu A K L, et al. Plasma inflamma-tory cytokines and chemokines in severe acute respiratory syndrome[J]. Clinical & Experimental Immunology, 2004, 136(1): 95-103.
[35] Mahallawi W H, Khabour O F, Zhang Q, et al. MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile[J]. Cytokine, 2018, 104: 8-13.
[36] Munster V J, Koopmans M, van Doremalen N, et al. A Novel Coronavirus Emerging in China-Key Questions for Impact Assessment[J]. New England Journal of Medicine, 2020.

相似文献/References:

[1]朱 峥 综述 陈 刚 审校.新型冠状病毒肺炎临床研究前后对比及特殊人群临床特点[J].福建医药杂志,2020,42(02):7.
[2]张飞扬 陈 刚.中外新型冠状病毒感染的肺炎诊疗指南之异同[J].福建医药杂志,2020,42(02):12.

备注/Memo

备注/Memo:
1 通信作者,Email:chengangfj@163.com; 福建医科大学省立临床医学院; 福建省医学科学研究院 福建省医学测试重点实验室(福州 350001)
更新日期/Last Update: 2020-03-30