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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:

39

期数:

2017年3期

页码:

68-70

栏目:

实验研究

出版日期:

2017-06-15

文章信息/Info

Title:

Observation of light microscope after autogenous nerve transplantation on spinal cord injured in rats

作者:

林潇哲[1]; 刘文革[2]; 陈上卫[1]; 徐光辉[1]

福建卫生职业技术学院附属医院福建省级机关医院骨科福州350001福建医科大学附属协和医院骨科

Author(s):

LIN Xiaozhe[1]; LIU Wenge[2]; CHEN Shangwei[1]; XU Guanghui[1]

关键词:

脊髓损伤; 自体神经; 移植; 病理:大鼠

Keywords:

spinal cord injury; autologous nerve; transplantation; pathology; rat

分类号:

R651.2

摘要:

目的探讨大鼠脊髓损伤后使用自体腓肠神经组织移植修复后的病理变化.方法将实验动物分为自体腓肠神经移植组和非移植组各18例.两组利用改良Allen撞击方法建立脊髓损伤模型,损伤4周后移植组利用自体腓肠神经移植修复脊髓损伤段,非移植组仅暴露切口不做处理.分别于术后4、6、8周在光镜下观察脊髓损伤段及移植腓肠神经再生状况.结果非移植组脊髓损伤段退化、变性,可见囊性空腔及瘢痕.移植组术后4周损伤区脊髓与移植物呈非紧密结合;术后6周融合良好;术后8周见再生神经纤维,通过损伤段与远端脊髓有机融合.与非移植组各组相比的差异有统计学意义(P<0.01).结论自体神经移植修复大鼠脊髓损伤移植物不仅良好存活,而且促进受损脊髓轴突再生.

Abstract:

Objective To investigate the pathological changes of autogenous sural nerve transplantation on spinal cord injured in rats.Methods The animals were divided into two groups.All of them used modified Allen impact method to establish model of spinal cord injury.After four weeks,the transplantation group used autologous sural nerve graft to repair spinal cord injury period,the non-transplantation group only exposed incision without treatment.In the 4,6 and 8 weeks after operation,observation of regeneration of the injured spinal cord in the light microscope was performed.Results In the non-transplantation group,spinal cord represented degeneration,cystic cavity and cicatrix were found.In the transplantation group,most of peripheral nerve survived,and was fused with the spinal tissue with time lapse after transplantation.Compared with the non-transplantation group,there were significant differences (P<0.01).Conclusion After spinal cord injury,autologous nerve graft is repaired and survived well and can promote the recovery of spinal cord injury.

备注/Memo

备注/Memo:

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更新日期/Last Update: 1900-01-01