[1]江若红,陈云丽,张亚敏,等.基于网络药理学探讨泽泻饮治疗“酒风”的作用机制[J].福建医药杂志,2023,45(06):119-123.
　JIANG Ruohong,CHEN Yunli,ZHANG Yamin,et al.Mechanism of Zexieyin in the treatment of “Jiufeng” based on network pharmacology[J].FUJIAN MEDICAL JOURNAL,2023,45(06):119-123.
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基于网络药理学探讨泽泻饮治疗“酒风”的作用机制()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期数:
2023年06期
页码:
119-123
栏目:
基础研究
出版日期:
2023-12-15

文章信息/Info

Title:
Mechanism of Zexieyin in the treatment of “Jiufeng” based on network pharmacology
文章编号:
1002-2600(2023)06-0119-05
作者:
江若红; 陈云丽; 张亚敏1; 林文津1; 2
福建中医药大学(福州 350001)
Author(s):
JIANG Ruohong;  CHEN Yunli;  ZHANG Yamin;  LIN Wenjin
Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350001, China
关键词:
泽泻饮;  网络药理学;  “酒风”;  分子对接;  作用机制
Keywords:
Zexieyin;  network pharmacology;  Jiufeng;  molecular docking;  mechanism
分类号:
R963
文献标志码:
A
摘要:
目的 通过网络药理学探讨泽泻饮治疗“酒风”的作用机制。方法 利用多个数据库收集泽泻饮治疗“酒风”的活性成分和交集靶点,随后构建蛋白互作网络图、药物-活性成分-交集靶点网络图,并进行富集分析和分子对接验证。结果 筛选出6个核心活性成分,分别为山柰酚、槲皮素、泽泻醇A、23-乙酰泽泻醇B、泽泻醇C 、白术内酯I,IL-1β、TNF、AKT1、MAPK3等8个关键靶点。通过Metascape数据库分析后得到450条GO 生物过程及 192条KEGG 相关信号通路,主要涉及癌症通路、TRP 通道的炎症介质调节、AMPK信号通路等。核心活性成分与关键靶点的结合能力较好。结论 通过网络药理学和分子对接验证,发现其可以通过山柰酚、槲皮素、泽泻醇A、23-乙酰泽泻醇B、泽泻醇C、白术内酯I等成分作用于IL-1β、TNF、AKT1、MAPK3等靶点发挥抗炎、免疫、调控细胞增殖凋亡等作用,为今后进一步研究“酒风”提供依据。
Abstract:
Objective To explore the mechanism of action of Zexieyin in the treatment of “Jiufeng” through network pharmacology.Methods Using multiple databases to collect the active ingredients and intersection targets of Zexieyin in the treatment of “Jiufeng”, then constructing protein interaction network diagrams and drug active ingredient intersection target network diagrams, and conducting enrichment analysis and molecular docking verification.Results Six core active ingredients were selected, including kaempferol, quercetin, alisol A, 23-acetylalisol B, alisol C, atractylolide I, and eight key targets including IL-1 β、 TNF, AKT1, MAPK3.After analyzing the Metascape database, 450 GO biological processes and 192 KEGG related signaling pathways were identified, mainly involving cancer pathways, inflammatory mediator regulation of TRP channels, and AMPK signaling pathways.The binding ability of the core active ingredients to key targets is good.Conclusion Through the network pharmacology and molecular docking verification, it is found that it can act on targets such as IL-1β, TNF, AKT1, and MAPK3 through kaempferol, quercetin, alisol A, 23-acetyl alisol B, alisol C, atractylide I and other components,and play a role in anti-inflammation, immunity, regulation of cell proliferation and apoptosis, and providing a basis for further research on “Jiufeng” in the future.

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备注/Memo

备注/Memo:
基金项目:福建省属公益科研院所基本专项( 2021R1012001); 福建省医学创新课题(2021CXA038)
1 福建省医学科学研究院 福建省医学测试重点实验室; 2 通信作者,Email:Lwj680@139.com
更新日期/Last Update: 2023-12-15