[1]伍林招,张韬,刘熹阳,等.乙醇胺改性聚己内酯制备亲水性组织工程支架的研究[J].福建医药杂志,2022,44(02):114-116.
　WU Linzhao,ZHANG Tao,LIU Yan,et al.Preparation of hydrophilic tissue engineering scaffold by modified polycaprolactone with ethanolamine[J].FUJIAN MEDICAL JOURNAL,2022,44(02):114-116.
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乙醇胺改性聚己内酯制备亲水性组织工程支架的研究()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期数:
2022年02期
页码:
114-116
栏目:
基础研究
出版日期:
2022-04-15

文章信息/Info

Title:
Preparation of hydrophilic tissue engineering scaffold by modified polycaprolactone with ethanolamine
文章编号:
1002-2600(2022)02-0114-03
作者:
伍林招; 张韬1; 刘熹阳; 刘岩; 刘楠楠
厦门大学附属福州第二医院骨科研究所(福州 350001)
Author(s):
WU Linzhao;  ZHANG Tao;  LIU Yan;  LIU Nannan
Department of Orthopedics Institute, the Fuzhou Second Hospital Affiliated to Xiamen University, Fuzhou, Fujian 350001, China
关键词:
组织工程;  组织修复;  支架
Keywords:
tissue engineering;  tissue repair;  scaffold
分类号:
R318
文献标志码:
A
摘要:
目的 探讨聚己内酯材料亲水性能增强的改性方法及工艺条件,制备有利于细胞黏附的亲水性组织工程支架。方法 通过碱性乙醇胺与聚己内酯间发生氨解反应形成酰胺键,在聚己内酯表面接枝亲水性的氨基和羟基,改善其亲水性能。在-80 ℃凝胶化相分离制备类细胞外基质的纳米纤维组织工程支架。结果 扫描电子显微镜(SEM)图显示支架呈多孔状结构,支架的亲水性能增强。结论 当凝胶化为-80 ℃时,类似于细胞外基质的纳米纤维状组织工程支架形成,支架孔隙率均大于80%,改性剂浓度增大支架的亲水性增强。
Abstract:
Objective The modification methods and technological conditions of polycaprolactone material with enhanced hydrophilicity were investigated to prepare tissue engineering scaffolds which were beneficial to cell adhesion and growth.Methods The hydrophilic properties of polycaprolactone were improved by grafting hydrophilic amino and hydroxyl groups on the surface of polycaprolactone, which was formed by ammonolysis reaction between ethanolamine and polycaprolactone.The extracellular matrix-like nanofiber tissue engineering scaffolds were prepared by gel phase separation at -80 ℃.Results SEM image showed that the scaffold had a porous structure, and the hydrophilicity of scaffold was enhanced.Conclusion When gelated at -80 ℃, nanofibrous tissue engineering scaffolds similar to extracellular matrix were formed,and the porosity of scaffolds was more than 80%.With the increase of modifier concentration, the hydrophilicity of scaffolds was enhanced.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:2020年福州市卫生健康科技创新平台建设项目(2020-S-wp3)
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更新日期/Last Update: 2022-04-15