[1]伍林招,张韬,刘岩,等.亲水改性聚乳酸基可降解骨支架的制备及性能研究[J].福建医药杂志,2021,43(03):106-108.
　WU Linzhao,ZHANG Tao,LIU Yan,et al.Preparation and properties of hydrophilic modified polylactide based degradable bone scaffolds[J].FUJIAN MEDICAL JOURNAL,2021,43(03):106-108.
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亲水改性聚乳酸基可降解骨支架的制备及性能研究()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期数:
2021年03期
页码:
106-108
栏目:
基础研究
出版日期:
2021-06-15

文章信息/Info

Title:
Preparation and properties of hydrophilic modified polylactide based degradable bone scaffolds
文章编号:
1002-2600(2021)03-0106-03
作者:
伍林招; 张韬1; 刘岩; 刘楠楠
厦门大学附属福州第二医院骨科研究所(福州 350007)
Author(s):
WU Linzhao;  ZHANG Tao;  LIU Yan;  LIU Nannan
Department of Orthopedics Institute, the Affiliated Fuzhou Municipal Second Hospital,Xiamen University, Fuzhou,Fujian 350007, China
关键词:
骨组织工程;  骨组织修复;  支架
Keywords:
bone tissue engineering;  bone repair;  scaffold
分类号:
R68
文献标志码:
B
摘要:
目的 利用3-氨基-1.2-丙二醇对聚乳酸进行亲水改性,制备具有多孔形貌的亲水性仿生骨组织工程支架。方法 利用氨解反应对聚乳酸进行亲水改性,利用热致相分离法结合冷冻干燥法制备亲水性多孔骨组织工程支架,研究不同凝胶化时间对多孔支架的微观形貌及亲水性能的影响。结果 SEM图显示支架呈多孔状结构,支架的亲水性能增强。结论本研究开发的亲水性聚乳酸基多孔海绵状结构的骨组织工程支架适合于细胞生长,有利于细胞黏附,更有利于骨组织修复,有望应用于临床。
Abstract:
Objective To prepare a hydrophilic bionic bone tissue engineering scaffold with porous morphology by hydrophilic modification of polylactic acid with 3-amino-1.2-propanediol.Methods The hydrophilic porous bone tissue engineering scaffolds were prepared by thermally induced phase separation and freeze-drying method.The effects of different gelation time on the microstructure and hydrophilicity of the scaffolds were studied.Results SEM showed that the scaffold had a porous structure and its hydrophilicity was enhanced.Conclusion The hydrophilic polylactide based spongy structure scaffold developed in this study is suitable for cell growth, conducive to cell adhesion and more conducive to bone tissue repair and is expected to be used in clinic.

参考文献/References:

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[2] Chen S Y, He Z H, Xu G J, et al. Fabrication and characterization of modified nanofibrous poly(L-lactic acid)scaffolds by thermally induced phase separation technique and aminolysis for promoting cyctocompatibility[J].Journal of Biomaterials Science, Polymer Edition, 2016, 27(10): 1058-1068.
[3] Wang J J, Zhou Z M, Zhang Z B, et al.Biomimetic synthesis of platelet-shaped hydroxyapatite mesocrystals in a collagen mimetic peptide-PEG hybrid hydrogel[J].Materials Letters, 2015, 159(15): 150-153.
[4] Mohammadi M, Li Y, Abebe D H, et al.Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages[J]. Journal of Controlled Release, 2016, 244(1): 269-279.
[5] You R, Xu Y M, Liu Y, et al.Comparison of the in vitro and in vivo degradations of silk fibroin Scaffolds from mulberry and nonmulberry silkworms[J]. Biomedical Materials, 2015, 10(1): 15003.

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[1]伍林招 吴学军.聚己内酯/壳聚糖-磷酸钙骨水泥支架的制备及其性能研究[J].福建医药杂志,2020,42(01):31.

备注/Memo

备注/Memo:
基金项目:2019年福州市科技计划项目(2019-SZ-13); 2020年福州市卫生健康科技创新平台建设项目(2020-S-wp3); 福建省级临床重点专科建设项目
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更新日期/Last Update: 2021-06-15