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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:

47

期数:

2025年01期

页码:

77-80101

栏目:

基础研究

出版日期:

2025-01-20

文章信息/Info

Title:

Study on effects of propofol on depressive-like behaviors and learning-memory in depressive model mice

文章编号:

1002-2600(2025)01-0077-05

作者:

陈峰

福建省福州市长乐区人民医院麻醉科,福州 350200

Author(s):

CHEN Feng

Department of Anesthesiology, Changle District People's Hospital, Fuzhou, Fujian 350200, China

关键词:

丙泊酚;  抑郁症模型;  抑郁样行为;  学习记忆

Keywords:

propofol;  depressive model;  depressive-like behavior;  learning-memory

分类号:

R74

DOI:

10.20148/j.fmj.2025.01.024

文献标志码:

A

摘要:

目的 探究丙泊酚对抑郁症模型小鼠抑郁样行为及学习记忆功能的影响。方法 取40只抑郁症模型小鼠,按照干预方法不同分为抑郁模型组和丙泊酚低剂量组(50 mg/kg)、中剂量组(75 mg/kg)、高剂量组(100 mg/kg),每组10只; 另取10只正常小鼠,设为正常对照组。丙泊酚低、中、高剂量组小鼠腹腔注射丙泊酚,抑郁模型组、正常对照组小鼠给予等容量生理盐水腹腔注射。丙泊酚注射24 h后进行悬尾实验、强迫游泳实验和糖水偏好测试,间隔7 d后各组重新进行相应的药物(丙泊酚或生理盐水)处理,24 h后进行Morris水迷宫测试。结果 抑郁模型组小鼠在悬尾状态和强迫游泳实验下静止时间均高于正常对照组,丙泊酚低、中、高剂量组小鼠在悬尾状态和强迫游泳实验下静止时间均低于抑郁模型组; 抑郁模型组小鼠糖水消耗百分比低于对照组,丙泊酚低、中、高剂量组小鼠糖水消耗百分比均高于抑郁模型组; 抑郁模型组小鼠逃避潜伏时间高于对照组,丙泊酚低、中、高剂量组小鼠逃避潜伏时间均低于抑郁模型组; 抑郁模型组小鼠空间探索时间低于对照组,丙泊酚低、中、高剂量组小鼠空间探索时间均高于抑郁模型组。以上组间差异均有统计学意义(P<0.05)。结论 丙泊酚可以缓解抑郁症小鼠的抑郁样行为,且会改善抑郁症小鼠的学习记忆功能。

Abstract:

Objective To investigate the effects of propofol on depressive-like behaviors and learning-memory functions in depressive model mice. Methods Forty depressive model mice were divided into a depressive model group and low-dose(50 mg/kg), medium-dose(75 mg/kg), high-dose(100 mg/kg)propofol groups according to different intervention methods, with 10 mice in each group. Another 10 normal mice were set as the normal control group. Mice in the low-dose, medium-dose, and high-dose propofol groups were intraperitoneally injected with propofol, while mice in the depressive model group and the normal control group were intraperitoneally injected with an equal volume of normal saline. Twenty-four hours after the propofol injection, the tail suspension test, forced swimming test, and sucrose preference test were carried out. After an interval of seven days, each group was re-treated with the corresponding drug(propofol or normal saline), and 24 hours later, the Morris water maze test was performed. Results The immobile time of mice in the depressive model group was higher than that in the normal control group in the tail suspension state and forced swimming test(P<0.05). The immobile time of mice in the low-, medium-, and high-dose propofol groups was lower than that in the depressive model group in the tail suspension state and forced swimming test(P<0.05). The percentage of sucrose consumption of mice in the depressive model group was lower than that in the control group(P<0.05). The percentage of sucrose consumption of mice in the low-, medium-, and high-dose propofol groups was higher than that in the depressive model group(P<0.05). The escape latency of mice in the depressive model group was higher than that in the control group(P<0.05). The escape latency of mice in the low-, medium-, and high-dose propofol groups was lower than that in the depressive model group(P<0.05). The spatial exploration time of mice in the depressive model group was lower than that in the control group(P<0.05). The spatial exploration time of mice in the low-, medium-, and high-dose propofol groups was higher than that in the depressive model group(P<0.05). Conclusion Propofol can alleviate the depressive-like behaviors of depressive mice and improve the learning-memory functions of depressive mice.

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更新日期/Last Update: 2025-01-20