[1]林生发,彭英,苏丽清,等.食管鳞癌表观扩散系数与分化程度、临床分期相关性分析[J].福建医药杂志,2022,44(02):1-4.
　LIN Shengfa,PENG Ying,SU Liqing,et al.Correlation analysis of apparent diffusion coefficient with differentiation degree and clinical stage of esophageal squamous cell carcinoma[J].FUJIAN MEDICAL JOURNAL,2022,44(02):1-4.
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食管鳞癌表观扩散系数与分化程度、临床分期相关性分析()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期数:
2022年02期
页码:
1-4
栏目:
临床研究
出版日期:
2022-04-15

文章信息/Info

Title:
Correlation analysis of apparent diffusion coefficient with differentiation degree and clinical stage of esophageal squamous cell carcinoma
文章编号:
1002-2600(2022)02-0001-04
作者:
林生发; 彭英; 苏丽清1; 沈衍富; 苏家威; 马明平2
福建医科大学省立临床医学院 福建省立医院放射科(福州 350001)
Author(s):
LIN Shengfa;  PENG Ying;  SU Liqing;  SHEN Yanfu;  SU Jiawei;  MA Mingping
Department of Radiology, Fujian Provincial Hospital,Provincial Clinical Medical College of Fujian Medical University, Fuzhou, Fujian 350001, China
关键词:
食管鳞癌;  表观扩散系数;  分化程度;  临床分期
Keywords:
esophageal squamous cell carcinoma;  apparent diffusion coefficient;  degree of differentiation;  clinical stage
分类号:
R735.1; R445.2
文献标志码:
B
摘要:
目的 探讨食管鳞癌表观扩散系数值(apparent diffusion coefficient,ADC)与分化程度、临床分期的相关性。方法 回顾性收集我院2019年5月至2020年7月手术证实为食管鳞癌的患者54例,所有病例均行磁共振成像(magnetic resonance imaging,MRI)常规序列检查、精确频率反转恢复弥散加权成像(spectral presaturation attenuated inversion recovery-diffusion weighted imaging,SPAIR-DWI)检查。由两名影像科主治医师分别在双盲情况下测定ADC平均值,对食管鳞癌分化程度、临床分期不同组间进行单因素方差分析、多重比较法分析及相关性分析。结果 低、中、高分化组ADC平均值组间差异有统计学意义(F=30.91,P<0.01),高分化>中分化>低分化,呈正相关(r=0.76,P<0.01); Ⅰ-Ⅳ期平均ADC值组间差异有统计学意义(F=19.42,P<0.01),Ⅰ期>Ⅱ期>Ⅲ期>Ⅳ期,呈负相关(r=-0.71,P<0.01)。结论 ADC值与食管鳞癌分化程度呈正相关,与临床分期呈负相关,能为临床诊疗方案、预后评估等提供客观影像依据。
Abstract:
Objective To explore the correlation between ADC value and differentiation degree and clinical stage of esophageal squamous cell carcinoma.Methods A total of 54 patients with esophageal squamous cell carcinoma confirmed by surgery in our hospital from May 2019 to July 2020 were collected retrospective, and all the cases underwent MRI routine sequence examination and SPIAR-DWI examination.Two attending radiologists measured the average ADC values under double-blind conditions, and performed univariate analysis of variance, multiple comparison analysis, and correlation analysis between the esophageal squamous cell carcinoma differentiation degree and clinical stage.Results The difference between the low, medium and high differentiated groups was statistically significant(F=30.91,P<0.01).The average ADC value: high differentiation> medium differentiation>low differentiation, which was positively correlated(r=0.76,P<0.01).There was a statistically significant difference between the groups in stage Ⅰ-Ⅳ(F=19.42,P<0.01).The average ADC value: stage Ⅰ> stage Ⅱ> stage Ⅲ> stage Ⅳ, which was negatively correlated(r=-0.71,P<0.01).Conclusion This study shows that ADC value is positively correlated with the degree of differentiation of esophageal squamous cell carcinoma, and negatively correlated with clinical staging.It can provide objective imaging basis for clinical diagnosis, treatment plan and prognosis evaluation.

参考文献/References:

[1] Abnet C C, Arnold M, Wei W Q.Epidemiology of esophageal squamous cell carcinoma[J].Gastroenterology, 2018,154(2):360-373.
[2] Omloo J M,Lagarde S M,Hulscher J B,et al.Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the mid/distal esophagus: five-year survival of a randomized clinical trial[J].Ann Surg,2007,246(6): 992-1000.
[3] Lei J,Han Q,Zhu S,et al.Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamiccontrast-enhanced magnetic resonanceimaging[J].OncolLett,2015,10(6): 3607-3612.
[4] Yang H, Liu H, Chen Y, et al.Neoadjuvant chemoradiotherapy followed by surgery versus surgeryalone for locally advanced squamous cell carcinoma of the esophagus(NEOCR-TEC5010): a phase Ⅲ multicenter, randomized, open-label clinical trial[J].J Clin Oncol,2018,36(27): 2796-2803.
[5] Leandri C, Soyer P,Oudjit A, et al.Contribution of magnetic resonance imaging to the management of esophageal diseases: a systematic review[J].European Journal of Radiology,2019(120):1-10.
[6] De Cobelli F,Palumbo D,Albarello L, et al.Esophagus and Stomach,is there a role for MR imaging?[J].Esophagus and Stomach,2020,28(1):1-15.
[7] Cong Q, Li G, Wang Y,et al.DW-MRI for esophageal squamous cell carcinoma, correlations between ADC values with histologic differentiation and VEGF expression: A retrospective study[J].Oncol Lett, 2019,17(3):2770-2776.
[8] Baliyan V, Das C J, Sharma R, et al.Diffusion weightedimaging:Technique and applications[J].World J Radiol, 2016, 8(9): 785.
[9] White N S, McDonald C R, Farid N, et al.Diffusion-weighted imaging in cancer: physical foundations and applications of restriction spectrum imaging[J].Cancer Res, 2014, 74(17): 4638-4652.
[10] Surov A,Meyer H J,Wienke A.Correlation between apparent diffusion coefficient(ADC)and cellularity is different in several tumors: a meta-analysis[J].Oncotarget 2007, 8(35):59492-59499.
[11] Hauge A,Wegner C S,Gaustad J V,et al.Diffusion-weighted MRI-derived ADC values reflect collagen I content in PDX models of uterine cervical cancer[J].Oncotarget,2017, 8(62):105682-105691.
[12] Hirata A,Hayano K,Ohira G,et al.volumetric histogram analysis of apparent diffusion coefficient as a biomarker to predict survival of esophageal cancer patients[J].AnnSurg Oncol,2020,27(8):3083-3089.
[13] Song T, Yao Q, Qu J,et al.The value of intravoxel incoherent motion diffusion-weighted imaging in predicting the pathologic response to neoadjuvant chemotherapy in locally advanced esophageal squamous cell carcinoma[J].EurRadiol, 2021,31(3):1391-1400.
[14] Liu G, Yang Z, Li T, Yang L,et al.Optimization of b-values in diffusion-weighted imaging for esophageal cancer: Measuring the longitudinal length of gross tumor volume and evaluating chemoradiotherapeutic efficacy[J].J Cancer Res Ther, 2017,13(5):748-755.
[15] 陈伟,王亚婷,柏根基,等.食管癌表观扩散系数值与病理预后因素的相关性分析[J].临床放射学杂志,2020,39(3):476-480.
[16] 武东杰,侯亚静.磁共振扩散加权成像在食管癌显示及恶性程度评估中的应用[J].现代医用影像学,2017,26(4):955-959.

备注/Memo

备注/Memo:
1 福建省肿瘤医院放诊科; 2 通信作者,Email:15806026770@163.com
更新日期/Last Update: 2022-04-15