[1]陈培杰,白培明,罗广承,等.原发与复发转移性嗜铬细胞瘤/副神经节瘤的临床特征对比分析[J].福建医药杂志,2022,44(02):4-6.
　CHEN Peijie,BAI Peiming,LUO Guangcheng,et al.Comparison and analysis of clinic features of primary and recurrent/metastatic phaeochromocytoma/paraganglioma[J].FUJIAN MEDICAL JOURNAL,2022,44(02):4-6.
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原发与复发转移性嗜铬细胞瘤/副神经节瘤的临床特征对比分析()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期数:
2022年02期
页码:
4-6
栏目:
临床研究
出版日期:
2022-04-15

文章信息/Info

Title:
Comparison and analysis of clinic features of primary and recurrent/metastatic phaeochromocytoma/paraganglioma
文章编号:
1002-2600(2022)02-0004-03
作者:
陈培杰; 白培明1; 罗广承; 郦守国2; 陈雍君3
厦门大学附属中山医院泌尿外科(厦门 361004)
Author(s):
CHEN Peijie;  BAI Peiming;  LUO Guangcheng;  LI Shouguo;  CHEN Yongjun
Department of Urology, the Affiliated Zhongshan Hospital of Xiamen University, Xiamen, Fujian 361004, China
关键词:
嗜铬细胞瘤;  副神经节瘤;  临床特征;  预后
Keywords:
phaeochromocytoma;  paraganglioma;  clinic features;  prognosis
分类号:
R736.6
文献标志码:
B
摘要:
目的 分析原发与复发转移性嗜铬细胞瘤/副神经节瘤(PPGL)患者的临床特征差异,以改善复发转移性患者的预后。方法 收集2011年6月至2021年6月我院各科室收治的107例PPGL患者资料并随诊; 对比原发与复发移性PPGL患者,以及对比复发转移性嗜铬细胞瘤与副神经节瘤患者的有关临床指标,并行统计分析。结果 大于5 cm的肿瘤、肿瘤内坏死/液化、CgA强阳性(++)及Ki-67指数>5%的复发/转移性PPGL患者比例,显著高于原发性PPGL的比例,差异有统计学意义(P<0.05)。与复发/转移性嗜铬细胞瘤相比,复发/转移性副神经节瘤更大、更易液化坏死,CgA强阳性和Ki-67指数>5%的比例更高(P<0.05)。结论 大于5 cm的肿瘤、肿瘤内液化坏死、Ki67指数高以及CgA强阳性的PPGL患者,发生复发/转移的可能性大; 相对于嗜铬细胞瘤,副神经节瘤的患者更易出现复发和转移,其预后也更差。
Abstract:
Objective In order to improve the prognosis of recurrent and metastatic phaeochromocytoma/paraganglioma(PPGL), analysis of clinic features of primary and recurrent/metastatic PPGL.Methods A total of 107 cases of PPGL in our hospital were recruited from Jun 2010 to Jun 2021.Clinic features of primary PPGL and recurrent/metastatic PPGL, and those of recurrent/metastatic phaeochromocytoma and recurrent/metastatic paraganglioma were compared and analyzed statistically.Results The patient proportion of tumor >5 cm in diameter、tumor necrosis and liguefaction、strong positive CgA and >5% Ki-67 index in recurrent/metastatic PPGL were statistically higher than those in primary PPGL(P<0.05).Compared with recurrent/metastatic phaeochromocytoma, recurrent/metastatic paraganglioma were lager,leading to necrosis and liguefaction more easily,and the patient proportion of strong positive CgA and >5% Ki-67 index were statistically higher(P<0.05).Conclusion Patient of the PPGL with tumor >5 cm in diameter,tumor necrosis and liguefaction,strong positive CgA and >5% Ki-67 index,become more recurrent and metastatic likely.Compared with phaeochromocytoma,paraganglioma is more recurrent and metastatic easily with poorer prognosis.

参考文献/References:

[1] 嗜铬细胞瘤和副神经节瘤诊断治疗专家共识(2020 版)[J].中华内分泌代谢杂志,2020,36(9):737-750.
[2] Hamidi O,Young W F Jr,Gruber L, et al.Outcomes of patients with metastatic phaeochromocytoma and paraganglioma: a systematic review and meta-analysis[J].Clin Endocrinol(Oxf),2017,87: 440-450.
[3] Lam A K.Update on adrenal tumors in 2017 World Health Organization(WHO)of endocrine tumors[J].Endoer Pathol,2017,28(3):213-227.
[4] 邓建华,李汉忠.转移性嗜铬细胞瘤/副神经节瘤的临床诊断和预后[J].协和医学杂志,2019,10(6):654-659.
[5] Kimura N,Takayanagi R,Takizawa N,et al. Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma[J]. Endocr Relat Cancer,2014,21: 405-414.
[6] 林洁,郭慈仁,陈雪燕, 等.P16蛋白和Ki-67抗原在宫颈上皮内瘤变分级诊断中的价值[J].福建医药杂志,2021,43(6):16-17.
[7] Azizan N, Hayati F, Tizen N M S,et al.Role of coexpression of estrogen receptor beta and Ki-67 in prostate adenocarcinoma[J].Investig Clin Urol, 2018,59(4):232-237.
[8] Domínguez N,Estévez-Herrera J,Pardo M R,et al.The functional role of chromogranin in exocytosis[J].J Mol Neurosci,2012,48(2):317-322.

备注/Memo

备注/Memo:
1 通信作者,Email:paja_chen@sina.com.cn; 2 肿瘤放疗科; 3 脊柱外科
更新日期/Last Update: 2022-04-15