参考文献/References:
[1] 党佳蓉,党琳慧,郭煦妍,等.糖尿病肾病的发病机制研究[J].医学信息,2022,35(17):161-165.
[2] WILLEMSEN S,HARTOG J W L,HEINER-FOKKEMA M R,et al.Advanced glycation end-products,a pathophysiolo-gical pathway in the cardiorenal syndrome[J].Heart failure reviews,2012,17(2):221-228.
[3] YAMAGISHI S,MATSUI T.Advanced glycation end products,oxidative stress and diabetic nephropathy[J].Oxidative medicine and cellular longevity,2010,3(2):101-108.
[4] CUI Q Q,LI X M,XIE Y.Study on the mechanism of warming yang and reducing turbidity decoction in the treatment of diabetic kidney disease based on network pharmacology[J].Medicine,2022,101(39):e30728.
[5] MA X,HAO C,YU M,et al.Investigating the molecular mechanism of quercetin protecting against podocyte injury to attenuate diabetic nephropathy through network pharmacology,microarraydata analysis,and molecular docking[J].Evidence-based complementary and alternative medicine:eCAM,2022,2022:7291434.
[6] CHUNG H,SEO E,JUN H S.Effects of Psoralea corylifolia L.seed extract on AGEs-induced cell proliferation and fibrotic factor expression in mesangial cells[J].Experimental and therapeutic medicine,2021,22(5):1332.
[7] HARDIE D G.AMPK:a key regulator of energy balance in the single cell and the whole organism[J].International journal of obesity,2008,32(4):S7-S12.
[8] RUDERMAN N B,CARLING D,PRENTKI M,et al.AMPK,insulin resistance,and the metabolic syndrome[J].The Journal of clinical investigation,2013,123(7):2764-2772.
[9] SAHA A K,XU X J,BALON T W,et al.Insulin resistance due to nutrient excess:is it a consequence of AMPK downregulation?[J].Cell cycle,2011,10(20):3447-3451.
[10] 薛剑,乔晨.紫苏叶提取物通过AMPK/mTOR自噬信号通路改善糖尿病肾病大鼠肾脏损伤研究[J].中医药学报,2023,51(9):18-22.
[11] 王江侠,杨丽霞,米登海,等.当归多糖对糖尿病肾病KK-Ay小鼠肾脏AMPK信号通路及线粒体自噬的影响[J].中草药,2023,54(10):3189-3196.
[12] 宋珂,宋丹,宋纯东,等.基于Keap1/Nrf2/ARE通路探讨益气养阴活血方对糖尿病肾病大鼠的肾脏保护作用机制[J].时珍国医国药,2023,34(5):1049-1052.
[13] ZHANG J,ZHAO X,ZHU H,et al.Crocin protects the renal tubular epithelial cells against high glucose-induced injury and oxidative stress via regulation of the SIRT1/Nrf2 pathway[J].Iranian Journal of Basic Medical Sciences,2022,25(2):193-197.
[14] INOGUCHI T,YU H Y,IMAMURA M,et al.Altered gap junction activity in cardiovascular tissues of diabetes[J].Medical Electron Microscopy,2001,34(2):86-91.
[15] OSICKA T M,YU Y,PANAGIOTOPOULOS S,et al.Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C[J].Diabetes,2000,49(1):87-93.
[16] SCIVITTARO V,GANZ M B,WEISS M F.AGEs induce oxidative stress and activate protein kinase C-βII in neonatal mesangial cells[J].American Journal of Physiology-Renal Physiology,2000,278(4):F676-F683.
[17] DUNLOP M.Aldose reductase and the role of the polyol pathway in diabetic nephropathy[J].Kidney international,2000,58:S3-S12.
[18] 夏青松,周俪珊,吴凡,等.胡芦巴丸调控氧化应激通路改善大鼠糖尿病肾病的实验研究[J].世界中医药,2021,16(19):2831-2838.
[19] 赵苗鑫,胡相卡,董苏敏,等.红花黄色素对糖尿病肾病小鼠肾的保护作用及机制研究[J].中国比较医学杂志,2021,31(8):76-81.
[20] OECKINGHAUS A,GHOSH S.The NF-κB family of transcription factors and its regulation[J].Cold Spring Harbor perspectives in biology,2009,1(4):a000034.
[21] RYBICKI B A,SADASIVAN S M,CHEN Y,et al.Growth and differentiation factor 15 and NF-κB expression in benign prostatic biopsies and risk of subsequent prostate cancer detection[J].Cancer Medicine,2021,10(9):3013-3025.
[22] ZHAO W,HE C,JIANG J,et al.The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy[J].The Korean Journal of Physiology & Pharmacology:Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology,2022,26(6):427-438.
[23] 池杨峰,刘爽,黄洁波,等.黄芪汤通过TLR4/NF-κB信号通路改善糖尿病肾病大鼠炎症反应的研究[J].临床肾脏病杂志,2022,22(1):39-45.
[24] 张旭东,任桂灵,陈慧慧,等.汉黄芩素调控TLR4/MAPK/NF-κB信号通路对糖尿病肾病大鼠肾纤维化的影响[J/OL].中国药理学通报,2023(10):1840-1846.
[25] HUANG X,LIU G,GUO J,et al.The PI3K/AKT pathway in obesity and type 2 diabetes[J].International Journal of Biological Sciences,2018,14(11):1483.
[26] ZENG L F,XIAO Y,SUN L.A glimpse of the mechanisms related to renal fibrosis in diabetic nephropathy[J].Renal Fibrosis:Mechanisms and Therapies,2019,1165:49-79.
[27] SANAJOU D,BAHRAMBEIGI S,ASLANI S.β-LAPachone is renoprotective in streptozotocin-induced diabetic mice via regulating the PI3K/Akt/mTOR signaling pathway[J].Iranian Journal of Basic Medical Sciences,2021,24(5):650-656.
[28] LU Q,WANG W W,ZHANG M Z,et al.ROS induces epithelialmesenchymal transition via the TGFβ1/PI3K/Akt/mTOR pathway in diabetic nephropathy[J].Experimental and Therapeutic Medicine,2019,17(1):835-846.
[29] HU Y,WANG S X,WU F Y,et al.Effects and mechanism of Ganoderma lucidum polysaccharides in the treatment of diabetic nephropathy in streptozotocin-induced diabetic rats[J].BioMed Research International,2022,2022:4314415.
[30] 乔进,赵彦,陈霞,等.基于PI3K/Akt/FoxO1通路探讨大黄酸对2型糖尿病大鼠肾损伤的作用[J].中成药,2023,45(2):609-613.
[31] MIYAZONO K,TEN DIJKE P,HELDIN C H.TGF-beta signaling by Smad proteins[J].Adv Immunol,2000,75:115-157.
[32] 周靖,郭洋洋,陆春红,等.藏红花素对糖尿病肾病大鼠肾纤维化的影响及机制研究[J].天津中医药,2023,40(4):513-517.
[33] LIN H C H,PAUL C R,KUO C H,et al.Glycyrrhiza uralensis root extract ameliorates high glucose-induced renal proximal tubular fibrosis by attenuating tubular epithelial-myofibroblast transdifferentiation by targeting TGF-β1/Smad/Stat3 pathway[J].Journal of Food Biochemistry,2022,46(5):e14041.
[34] Recio C,Lazaro I,Oguiza A,et al.Suppressor of cytokine signaling-1 peptidomimetic limits progression of diabetic nephropathy[J].Journal of the American Society of Nephro-logy:JASN,2017,28(2):575-585.
[35] CHEN D,LIU Y,CHEN J,et al.JAK/STAT pathway promotes the progression of diabetic kidney disease via autophagy in podocytes[J].European Journal of Pharmacology,2021,902:174121.
[36] GAO C,FEI X,WANG M,et al.Cardamomin protects from diabetes-induced kidney damage through modulating PI3K/AKT and JAK/STAT signaling pathways in rats[J].International Immunopharmacology,2022,107:108610.
[37] 陈彦旭,金智生,姜晓雪,等.基于JAK2/STAT3信号通路探讨红芪多糖对糖尿病肾病db/db小鼠作用机制[J].中国实验方剂学杂志,2023,29(13):65-71.