[1]林俊生,林慧洁,戴炜,等.CD4+Foxp3+调节性T细胞在急性髓系白血病中的变化及其预后意义[J].福建医药杂志,2024,46(02):10-13.[doi:10.20148/j.fmj.2024.02.003]
　LIN Junsheng,LIN Huijie,DAI Wei,et al.Changes of regulatory T Cells in acute myeloid leukemia and its prognostic significance[J].FUJIAN MEDICAL JOURNAL,2024,46(02):10-13.[doi:10.20148/j.fmj.2024.02.003]
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CD4+Foxp3+调节性T细胞在急性髓系白血病中的变化及其预后意义()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期数:
2024年02期
页码:
10-13
栏目:
临床研究
出版日期:
2024-04-15

文章信息/Info

Title:
Changes of regulatory T Cells in acute myeloid leukemia and its prognostic significance
文章编号:
1002-2600(2024)02-0010-04
作者:
林俊生1; 林慧洁2; 戴炜1; 黄晓宇2; 陈君涵1; 张鑫2; 陈加弟1
1 福建医科大学附属协和医院检验科,福州 350001; 2 福建医科大学医学技术与工程学院医学检验系,福州 350004
Author(s):
LIN Junsheng1; LIN Huijie2; DAI Wei1; HUANG Xiaoyu2; CHEN Junhan1; ZHANG Xin2; CHEN Jiadi1
1 Department of clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China; 2 Department of Medical Laboratory, School of Medical Technology and Engineering, Fujian University, Fuzhou, Fujian 350004, China
关键词:
急性髓系白血病;  调节性T细胞;  流式细胞术;  预后
Keywords:
acute myeloid leukemia;  regulatory T cells;  flow cytometry;  prognosis
分类号:
R551.3
DOI:
10.20148/j.fmj.2024.02.003
文献标志码:
B
摘要:
目的 探究CD4+Foxp3+调节性T细胞(Tregs)在急性髓系白血病(AML)中的变化,并研究其与AML预后的关系。方法 采用流式细胞术检测来我院就诊的初诊AML患者和健康对照组外周血Tregs水平; 根据细胞核型将AML分为预后较好组、预后中等组和预后较差组,比较各组患者Tregs占CD4+T细胞比例,研究外周血Tregs对AML预后的意义。结果 AML患者外周血CD4+Foxp3+ Tregs占CD4+T细胞比例高于健康对照组(6.171%±0.292% vs. 2.437% ± 0.144%,P<0.000 1); 但是各AML亚型中Tregs占CD4+T细胞比例差异无统计学意义(P>0.05); 预后较差组AML患者外周血Tregs占CD4+T细胞比例高于预后较好组(7.316%±0.592% vs. 5.179%±0.429%,P<0.01)。结论 AML患者外周血CD4+Foxp3+ Tregs占CD4+T细胞比例提高,对AML患者预后评估有一定的意义。
Abstract:
Objective To investigate the changes of CD4+Foxp3+ regulatory T cells(Tregs)in acute myeloid leukemia(AML)and its relationship with the prognosis of AML.Methods Flow cytometry was used to detect the percentages of Tregs among CD4+ T cells in peripheral blood of newly diagnosed AML patients and healthy controls.AML patients were divided into good prognosis group, medium prognosis group and poor prognosis group by cytogentic karyotype.Then, the difference in the percentages of Tregs among CD4+ T cells among each group was analyzed to explore the potential prognostic significance of Tregs in AML.Results The percentages of circulating CD4+Foxp3+ Tregs in AML patients was significantly higher than that of healthy controls(6.171% ± 0.292% vs. 2.437% ± 0.144%, P<0.000 1).There was no significant difference in the percentages of Tregs among CD4+ T cells among different subtypes of AML(P>0.05).We found that the ratio of circulating Tregs in the poor prognosis group was significantly higher than that in the better prognosis group(7.316%±0.592% vs. 5.179%±0.429%).Conclusion The percentages of CD4+Foxp3+Tregs among CD4+ T cells are significantly increased in patients with AML, which has certain significance for prognostic evaluation.

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备注/Memo

备注/Memo:
基金项目:福建省自然科学基金资助项目(2021J05049)
通信作者:陈加弟,Email:chenjd2013xh@fjmu.edu.cn
更新日期/Last Update: 2024-04-15