[1]苏川,齐元麟.M2型丙酮酸激酶在宫颈鳞状细胞癌和宫颈腺癌中临床意义的生物信息学分析[J].福建医药杂志,2024,46(02):1-5.[doi:10.20148/j.fmj.2024.02.001]
　SU Chuan,QI Yuanlin.Bioinformatics analysis of the clinical significance of PKM2 in cervical squamous cell carcinoma and endocervical adenocarcinoma[J].FUJIAN MEDICAL JOURNAL,2024,46(02):1-5.[doi:10.20148/j.fmj.2024.02.001]
点击复制

M2型丙酮酸激酶在宫颈鳞状细胞癌和宫颈腺癌中临床意义的生物信息学分析()
分享到：

《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期数:
2024年02期
页码:
1-5
栏目:
临床研究
出版日期:
2024-04-15

文章信息/Info

Title:
Bioinformatics analysis of the clinical significance of PKM2 in cervical squamous cell carcinoma and endocervical adenocarcinoma
文章编号:
1002-2600(2024)02-0001-05
作者:
苏川1; 齐元麟2
1 闽江师范高等专科学校,福州350109; 2 福建医科大学,福州350122
Author(s):
SU Chuan1; QI Yuanlin2
1 Minjiang Teachers College, Fuzhou, Fujian 350109, China; 2 Fujian Medical University, Fuzhou, Fujian 350122, China
关键词:
M2型丙酮酸激酶;  宫颈鳞状细胞癌和宫颈腺癌;  临床意义;  生物信息学
Keywords:
M2 type pyruvate kinase;  cervical squamous cell carcinoma and endocervical adenocarcinoma;  clinical significance;  bioinformatics
分类号:
R319; R737.3
DOI:
10.20148/j.fmj.2024.02.001
文献标志码:
A
摘要:
目的 基于生物信息学方法分析M2型丙酮酸激酶(pyruvate kinase M2,PKM2)在宫颈鳞状细胞癌和宫颈腺癌(cervical squamous cell carcinoma and endocervical adenocarcinoma,CESC)中的临床意义。方法 通过R软件分析PKM2基因在CESC和正常宫颈组织中的表达差异; GEPIA平台分析PKM2基因对CESC病人总生存期(overall survival,OS)的影响; TIMER平台验证PKM2基因表达对CESC病人OS的影响; HPA平台分析PKM2蛋白表达对CESC病人OS的影响; TIMER平台分析免疫细胞浸润水平与PKM2基因表达及病人OS的相关性。结果 CESC病人中PKM2基因和蛋白质高表达病人的OS均劣于低表达者,CESC中PKM2基因表达还与免疫细胞浸润水平有关,而免疫细胞浸润水平又与病人的OS有关。结论 PKM2是CESC预后的不利因素,在CESC的诊断和治疗中可作为潜在的指标和靶点。
Abstract:
Objective To explore the clinical significance of M2 type pyruvate kinase(PKM2)in cervical squamous cell carcinoma and endocervical adenocarcinoma(CESC)based on bioinformatics method.Methods The expression differences of PKM2 gene between CESC and normal cervical tissue were analyzed using R software; the impact of PKM2 gene expression on overall survival(OS)of CESC patients was analyzed on GEPIA platform; the impact of PKM2 gene expression on the OS of CESC patients was verified on TIMER platform; the impact of PKM2 protein expression on the OS of CESC patients was analyzed on HPA platform; the correlation between immune cell infiltration levels, PKM2 gene expression, and patient OS was analyzed on TIMER platform.Results The OS of patients with high expression of PKM2 gene and protein in CESC was inferior to those with low expression, PKM2 gene expression in CESC is also related to the level of immune cell infiltration, which in turn is related to the OS of patients.Conclusion PKM2 is an unfavorable prognostic factor for CESC and can serve as a potential indicator and target in the diagnosis and treatment of CESC.

参考文献/References:

[1] SUNG H,FERLAY J,SIEGEL R L,et al.Global cancer statistics 2020:GLOB OCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA:A Cancer Journal for Clinicians,2021,71(3):209-249.
[2] 李想,刘灿,周维,等.2005-2015年中国宫颈癌发病与死亡趋势分析[J].华中科技大学学报:医学版,2021,50(3):325-330.
[3] 罗玲,潘嘉怡,陈新亮,等.六项肿瘤标志物在宫颈癌病理分型鉴别中的意义[J].岭南急诊医学杂志,2023,28(4):325-328.
[4] ZAHRA K,DEY T,ASHISH,et al.Pyruvate kinase M2 and cancer:The role of PKM2 in promoting tumorigenesis[J].Frontiers in Oncology,2020,10:159.
[5] WU J Y,HU L R,CHEN M Y,et al.Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system:Evidence from 16 cohort studies[J].Onco Targets Ther,2016,9:4277-4288.
[6] AMIN S,YANG P,LI Z.Pyruvate kinase M2:A multi-farious enzyme in non-canonical localization to promote cancer progression[J].Biochim Biophys Acta Rev Cancer,2019,1871(2):331-341.
[7] LI R,LI P,WANG J,et al.STIP1 down-regulation inhibits glycolysis by suppressing PKM2 and LDHA and inactivating the Wnt/β-catenin pathway in cervical carcinoma cells[J].Life Sciences,2020,258:118190.
[8] 孙红娜,王月荣,黄勇华,等.血清中PKM2和TSGF水平与宫颈癌患者病情进展的相关性[J].实用癌症杂志,2021,36(7):1072-1075.
[9] 蔡尚霞,姜海英,杨浩.宫颈、阴道分泌物和血清PKM2检测在子宫内膜癌、宫颈癌诊断中的意义[J].中国实验诊断学,2020,24(4):622-623.
[10] 谷守娟.PKM2在子宫内膜癌发病中的作用及其机制研究[D].天津:天津医科大学,2017.
[11] 毛赛平.PKM2、PTB在宫颈癌组织中的表达及意义[D].长沙:中南大学,2015.
[12] HUANG P,ZHAO X,XIAO W,et al.18F-fluorodeoxyglucoseuptake predicts PKM2 expression in lung adenocarcinoma[J].Oncotarget,2017,8(24):39618-39626.
[13] XIAO H,ZHANG L,CHEN Y,et al.PKM2 promotes breast cancer progression by regulating epithelial mesenchymal transition[J].Analytical cellular pathology(Amsterdam),2020,2020:8396023.
[14] LU J,CHEN M,GAO S M,et al.LY294002 inhibits the Warburgeffect in gastric cancer cells by downregulating pyruvate kinase M2[J].Oncol Lett,2018,15(4):4358-4364.
[15] 孟雨,李燕京,白玉贤.M2型丙酮酸激酶非代谢功能在肿瘤治疗中的研究进展[J].现代肿瘤医学,2022,30(17):3230-3234.
[16] 王彩虹,陈剑飞,鞠久君,等.PKM2促进肿瘤发展的作用机制研究[J].生物技术进展,2022,12(3):411-418.
[17] 刘琼,刘桂佑.宫颈分泌物中M2-PK的定量检测及在宫颈癌中的应用研究[J].湖南师范大学学报:医学版,2019,16(6):16-19.
[18] GUO M,ZHAO X,YUAN X,et al.MiR-let-7a inhibits cell proliferation,migration,and invasion by down-regulating PKM2 in cervical cancer[J].Oncotarget,2017,8(17):28226-28236.
[19] ZHAO Y,SHEN L,CHEN X,et al.High expression of PKM2 as a poor prognosis indicator is associated with radiation resistance in cervical cancer[J].Histology and Histopatho-logy,2015,30(11):1313-1320.

备注/Memo

备注/Memo:
通信作者:齐元麟,Email:2287557@qq.com
更新日期/Last Update: 2024-04-15