[1]陈冬冬,郑竑.BPQDs@TNTs药物载体的构建及其缓释性能研究[J].福建医药杂志,2024,46(01):21-24.[doi:10.20148/j.fmj.2024.01.006]
　CHEN Dongdong,ZHENG Hong.Construction of BPQDS@TNTS drug carrier and its sustained release properties[J].FUJIAN MEDICAL JOURNAL,2024,46(01):21-24.[doi:10.20148/j.fmj.2024.01.006]
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BPQDs@TNTs药物载体的构建及其缓释性能研究()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期数:
2024年01期
页码:
21-24
栏目:
临床研究
出版日期:
2024-02-15

文章信息/Info

Title:
Construction of BPQDS@TNTS drug carrier and its sustained release properties
文章编号:
1002-2600（2024）01-0021-04
作者:
陈冬冬; 郑竑
福建省福州市第二医院骨科，福州 300007
Author(s):
CHEN Dongdong;  ZHENG Hong
Department of Orthopaedics, Fuzhou Second Hospital, Fuzhou, Fujian 350007, China
关键词:
TiO2纳米管阵列; 黑磷量子点; 阿仑磷酸钠; 硫酸庆大霉素
Keywords:
TiO2 nanotube array;  black phosphorus quantum dots;  alendronate sodium phosphate;  sulfuric gentamicin
分类号:
R68
DOI:
10.20148/j.fmj.2024.01.006
文献标志码:
B
摘要:
目的在骨科钛板表面构建能负载阿仑膦酸钠及硫酸庆大霉素的双载药复合药物载体。方法通过阳极氧化法在TiO2表面制备纳米管阵列（TNTs），动态吸附阿伦磷酸钠后再填充载有硫酸庆大霉素的载药黑磷量子点（BPQDs），管口采用肉豆蔻醇进行封装，并利用X射线衍射、透射电镜进行表征，最后通过液相色谱法测定其上负载的阿仑膦酸钠及硫酸庆大霉素的缓释速率。结果X射线衍射表明构建的BPQDs@TNTs药物载体具备BP和TNTs的特征衍射峰，透射电镜扫描表明，肉豆蔻醇成功地对TNTs进行了封口，TiO2纳米管中的阿仑膦酸钠及BPQDs载体的硫酸庆大霉素在72 h内已基本释放完毕，BPQDs@TNTs药物载体上阿仑膦酸钠及硫酸庆大霉素则在96 h内才基本释放完毕。结论BPQDs@TNTs药物载体能成功搭载阿仑膦酸钠及硫酸庆大霉素，且在体液中具有更好的缓释效能。
Abstract:
ObjectiveTo construct a dual-drug-loaded composite drug carrier loaded with alendronate and gentamicin on orthopaedic titanium plate. MethodsNanotube arrays(TNTs) were prepared on the surface of TiO2 by anodic oxidation, then dynamically adsorbed sodium alendronate and were filled with gentamicin sulfate-loaded BP quantum dots(BPQDs).The tube mouth was encapsulated with nutmeg. The tube was characterized by X-ray diffraction and transmission electron microscopy.The sustained release rate of alendronate and gentamicin loaded on the tube was determined by chromatography. ResultsX-ray diffraction showed that the BPQDS@TNTS drug carrier had characteristic diffraction peaks of BP and TNTs. Transmission electron microscopy showed that nutmeg had successfully sealed TNTs, the alendronate and sulphate gentamicin in TiO2 nanotubes and BPQDs carriers were almost completely released within 72 hours, while the alendronate and sulphate gentamicin in BPQDs@TNTs carriers were almost completely released within 96 hours.ConclusionBPQDs@TNTs drug carrier can successfully carry alendronate and gentamicin sulfate, and has better sustained-release efficacy in body fluids.

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备注/Memo

备注/Memo:
基金项目：2021年福州市科技计划项目（2021-S-159）；2020年福建省卫健委医学创新课题B类（2020CXB037）
通信作者：郑竑，Email：zhenghong_fj@126.com
更新日期/Last Update: 2024-02-15