[1]刘岩,伍林招,刘楠楠,等.3D打印技术构建不同比例PLA/TiO2复合支架及其性能评估[J].福建医药杂志,2023,45(02):107-110.
 LIU Yan,WU Linzhao,LIU Nannan,et al.Construction and performance evaluation of PLA/TiO2 nanocomposite scaffolds with different proportions by 3D printing technology[J].FUJIAN MEDICAL JOURNAL,2023,45(02):107-110.
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3D打印技术构建不同比例PLA/TiO2复合支架及其性能评估()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期数:
2023年02期
页码:
107-110
栏目:
基础研究
出版日期:
2023-04-15

文章信息/Info

Title:
Construction and performance evaluation of PLA/TiO2 nanocomposite scaffolds with different proportions by 3D printing technology
文章编号:
1002-2600(2023)02-0107-04
作者:
刘岩伍林招刘楠楠张韬
福建省福州市第二医院骨科研究所(福州 350007)
Author(s):
LIU Yan WU Linzhao LIU Nannan ZHANG Tao
Department of Orthopedics Institute, Fuzhou Second Hospital, Fuzhou, Fujian 350007, China
关键词:
3D打印聚乳酸纳米TiO2复合支架细胞增殖
Keywords:
3D printing polylactic acid nano-TiO2 composite scaffold cell proliferation
分类号:
R816.8
文献标志码:
B
摘要:
目的 利用3D打印技术构建不同比例的聚乳酸/二氧化钛(PLA/TiO2)纳米复合支架,探究其相关性能。 方法 在PLA中分别添加1%、1.5%、2.5%、5%和10%的TiO2纳米颗粒。通过3D打印技术构建PLA/TiO2纳米复合支架,对其形貌、力学性能、孔隙率、热性能和生物性能进行表征。结果 与纯PLA支架相比,PLA/TiO2-1.5%、PLA/TiO2-2.5%支架具有更高的孔隙率和更好的力学性能。所有支架均为层层交互叠加的网状结构,孔径约200 μm,孔隙均匀规则。体外细胞增殖实验发现,所有支架均可促进小鼠胚胎成骨细胞增殖,PLA/TiO2-1.5%组支架的细胞增殖效果优于其他组支架(P<0.05)。结论 相比于其他支架,PLA/TiO2-1.5%支架具有适宜的力学性能,高孔隙率,更好地促进细胞增殖能力,可为骨缺损修复材料研究奠定基础。
Abstract:
Objective PLA/TiO2 nanocomposite scaffolds with different ratios were constructed by 3D printing technology, and their related properties were explored. Methods 1%, 1.5%, 2.5%, 5% and 10% of TiO2 nanoparticles were added to polylactic acid (PLA), respectively. The PLA/TiO2 nanocomposite scaffolds were constructed by 3D printing technology, and their morphology, mechanical properties, porosity, thermal properties and biological properties were characterized. Results Compared with pure PLA scaffolds, PLA/TiO2-1.5% and PLA/TiO2-2.5% scaffolds had higher porosity and better mechanical properties. All scaffolds were layer-by-layer reticular structures with a pore size of about 200 μm, and the pores were uniform and regular. In vitro cell proliferation experiments showed that all scaffolds could promote the proliferation of mouse embryonic osteoblasts, and the cell proliferation effect of scaffolds in PLA/TiO2-1.5% group was better than that in scaffolds in other groups (P<0.05). Conclusion Compared with other scaffolds, PLA/TiO2-1.5% scaffolds have suitable mechanical properties, high porosity, and better ability to promote cell proliferation, which can lay a foundation for the research on bone defect repair materials.

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备注/Memo

备注/Memo:
基金项目:福州市科技计划项目(2019-SZ-23);福建省科技创新平台项目“福建省创伤骨科急救与康复临床医学研究中心”(2020Y2014)
更新日期/Last Update: 2023-04-15