[1]石小松,杨芳.不同血浆N端脑钠肽前体界值对川崎病的诊断价值[J].福建医药杂志,2023,45(02):5-8.
　SHI Xiaosong,YANG Fang.Significance of different cut-off values of N-terminal pro-brain natriuretic peptide in the diagnosis of Kawasaki disease[J].FUJIAN MEDICAL JOURNAL,2023,45(02):5-8.
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不同血浆N端脑钠肽前体界值对川崎病的诊断价值()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期数:
2023年02期
页码:
5-8
栏目:
临床研究
出版日期:
2023-04-15

文章信息/Info

Title:
Significance of different cut-off values of N-terminal pro-brain natriuretic peptide in the diagnosis of Kawasaki disease
文章编号:
1002-2600(2023)02-0005-04
作者:
石小松; 杨芳1
福建省立医院南院儿科（福州 350028）
Author(s):
SHI Xiaosong;  YANG Fang
Department of Pediatrics, Fujian Provincial Hospital South Branch, Fuzhou, Fujian 350028, China
关键词:
N端脑钠肽前体; 川崎病; 界值
Keywords:
N-terminal pro-brain natriuretic peptide; Kawasaki disease;  cut-off value
分类号:
R725.4
文献标志码:
B
摘要:
目的 探讨不同血浆N端脑钠肽前体（NT-proBNP）界值对川崎病（KD）的诊断价值。方法 选取299例KD患儿作为观察组，将同期住院的107名发热患儿作为对照组，按年龄分层，比较不同组间儿童一般临床特征及血浆NT-proBNP水平，运用受试者工作特征曲线（ROC曲线）及曲线下面积（AUC），分析不同NT-proBNP界值对KD的诊断意义。结果 KD组NT-proBNP高于对照组，差异有统计学意义（P<0.001）。根据ROC曲线，NT-proBNP诊断KD的最佳界值为320.14 pg/mL，Youden指数为0.61；3～12月龄KD组NT-proBNP高于＞12月龄KD组（P<0.05），3～12月龄组与＞12月龄组诊断KD的最佳界值分别为356.42 pg/mL和209.33 pg/mL。结论 血浆NT-proBNP对KD有一定的诊断价值，在不同年龄组KD患儿有不同的最佳诊断界值。
Abstract:
Objective To investigate the diagnostic value of different cut-off values of plasma N-terminal pro-brain natriuretic peptide in Kawasaki disease(KD). Methods A total of 299 children with KD were selected as the observation group, 107 patients who were hospitalized during the same period were used as the control group, and stratified according to age. The general clinical characteristics and plasma NT-proBNP levels of children in different groups were compared, and the receiver operating characteristic curve (ROC curve) and area under the curve (AUC) were used to analyze the diagnostic significance of different NT-proBNP thresholds for KD. Results The plasma NT-proBNP level in the KD group was higher than that in the control group, showing a statistically significant difference (P<0.001). According to the ROC analysis, the optimal cut-off value of NT-proBNP for diagnosing KD was 320.14 pg/mL, the Youdens index was 0.61. The plasma NT-proBNP level in the 3-12 months group was higher than that in the >12 months group, showing a statistically significant difference (P<0.05). The ideal NT-proBNP cut-off levels for diagnosing KD in the 3-12 months group and the >12 months group were 356.42 pg/mL and 209.33 pg/mL, respectively.Conclusion The plasma NT-proBNP had certain diagnostic value for KD, showing different thresholds in children with KD in different age groups.

参考文献/References:

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备注/Memo

备注/Memo:
1 福建医科大学省立临床医学院 福建省立医院儿科（福州 350001）,通信作者，Email：yangfangfjsl@163.com
更新日期/Last Update: 2023-04-15