[1]刘小梅,庄良武,章斌斌.术前中性粒细胞/淋巴细胞比值对上皮性卵巢癌患者术后生存率的影响[J].福建医药杂志,2021,43(04):7-11.
　LIU Xiaomei,ZHUANG Liangwu,ZHANG Binbin.Preoperative neutrophil/lymphocyte ratio predicts postoperative survival rate in patients with epithelial ovarian cancer[J].FUJIAN MEDICAL JOURNAL,2021,43(04):7-11.
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术前中性粒细胞/淋巴细胞比值对上皮性卵巢癌患者术后生存率的影响()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期数:
2021年04期
页码:
7-11
栏目:
临床研究
出版日期:
2021-08-15

文章信息/Info

Title:
Preoperative neutrophil/lymphocyte ratio predicts postoperative survival rate in patients with epithelial ovarian cancer
文章编号:
1002-2600(2021)04-0007-05
作者:
刘小梅; 庄良武1; 章斌斌1
厦门大学附属福州第二医院妇科(福州 350007)
Author(s):
LIU Xiaomei; ZHUANG Liangwu; ZHANG Binbin
Department of Gynaecology，Fuzhou Second Hospital affiliated to Xiamen University，Fuzhou，Fujian 350007，China
关键词:
中性粒细胞/淋巴细胞比值; 上皮性卵巢癌; 生存率
Keywords:
neutrophil to lymphocyte ratio (NLR);  epithelial ovarian carcinoma (EOC);  survival rate
分类号:
R737.31
文献标志码:
B
摘要:
目的 探讨上皮性卵巢癌（EOC）术前中性粒细胞与淋巴细胞比值（NLR）与预后的相关性。 方法 回顾性分析93例EOC患者的临床资料，根据NLR预测总生存期（OS）的最优截点分组，分为高NLR组和低NLR组，比较两组病理因素、无进展生存期、总生存期的差异，采用单因素及多因素Cox风险分析EOC患者潜在的预后影响因素。 结果 术前NLR预测OS的最优截点为3.0，NLR≥3.0组在FIGO分期Ⅲ～Ⅳ期、不满意卵巢癌细胞减灭术、伴有腹水及淋巴转移所占比例，均高于NLR＜3.0（P<0.05）。低NLR组中位PFS（30个月）、中位OS（52个月），均显著高于NLR组（χ2=7.575，P<0.05；χ2=10.035，P<0.05）。Cox风险模型示：年龄、肿瘤细胞减灭术、淋巴转移、NLR≥3.0，均是PFS的独立危险因素；FIGO分期、肿瘤细胞减灭术、NLR≥3.0、血清CA125≥35 U/mL，均是OS的独立危险因素。 结论 NLR≥3.0预示ECO患者预后不良。
Abstract:
Objective To investigate the correlation between peripheral blood neutrophil and lymphocyte ratio (NLR) and prognosis of epithelial ovarian cancer (EOC)．Methods A total of 93 cases of clinicopathological data in EOC patients were retrospectively analyzed. Based on the optimal cut-off point of the NLR predicting OS，the patients were divided into high NLR group and low NLR. Pathological factors,PFS and OS were compared between the two groups. The single factor and multiple factors Cox risk analysis were used for the potential outcomes of patients with EOC influencing factors．Results According to the ROC curve result analysis，the optimal cut-off value of NLR predicting OS in patients with EOC was 3.0. The FIGO Ⅲ~Ⅳ stages，non-satisfactory ovarian cancer cytoreductive surgery，ascites and lymph node metastasis in NLR≥3.0 were all higher than those in NLR<3.0 (P<0.05)．The median PFS (30 months) and median OS (52 months) in the low NLR group were significantly longer than those in the high NLR group (χ2=7.575，P<0.05; χ2=10.035，P<0.05)．The multivariate Cox analysis results showed that age，ovarian cancer cytoreductive surgery，lymph node metastasis and NLR≥3.0 were all independent risk factors of PFS in EOC patients; advanced FIGO stage，ovarian cancer cytoreductive surgery，serum CA125 level and NLR≥3.0 were all independent risk factors of OS in EOC patients．Conclusion NLR≥3.0 predicts poor prognosis in patients with EOC．

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备注/Memo

备注/Memo:
1 福建中医药大学附属人民医院妇科
更新日期/Last Update: 2021-08-15