[1]郭国栋 晋 龙 童康梅 林 娟 陈志忠 吴义娟 陈小岩.后肾腺瘤10例临床诊治分析[J].福建医药杂志,2020,42(05):78-80.
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后肾腺瘤10例临床诊治分析()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期数:
2020年05期
页码:
78-80
栏目:
临床研究
出版日期:
2020-10-20

文章信息/Info

文章编号:
1002-2600(2020)05-0078-04
作者:
郭国栋 晋 龙1; 2 童康梅 林 娟 陈志忠2 吴义娟2 陈小岩2
福建省立医院南院病理科(福州 350028)
关键词:
后肾腺瘤;  临床病理;  诊断;  鉴别诊断;  预后
分类号:
R736.6
文献标志码:
B
摘要:
目的 探讨后肾腺瘤(metanephric adenoma MA)的临床病理特征、诊断、鉴别诊断及治疗预后。方法 回顾性分析我院收治MA患者10例的临床病理资料,讨论病理形态特点、免疫组化、分子病理特征、治疗预后。结果 右肾5例,左肾5例,肿瘤为灰黄、灰白色结节,直径0.2～6.5 cm(3.15±1.67)cm,界限清楚; 镜下为均匀一致的瘤细胞排列呈小管状或囊状扩张,核分裂象罕见; 免疫组化CK(pan)+、CD57+、Vimentin+、WT-1+,CK7-/+,EMA-、CD10-、AMACR-,Ki-67增殖指数低; PCR显示3例BRAFV600E突变; 患者随访14～107个月,均无瘤生存。结论 MA罕见且无特异性的临床特征,确诊需病理诊断,预后良好但生物学行为存在争议,术后仍需长期随访。

参考文献/References:

[1] Amin M B, Tamboli P, Javidan J, et al.Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405 cases[J].Am J Surg Pathol,2002,26(3):281-291.
[2] Davis C J, Barton J H, Sesterhenn I A, et al.Metanephric adenoma clinicopathological study of fifty patients[J].Am J Surg Pathol,1995,19(10):1101-1114.
[3] Jinzaki M, Tanimoto A, Mukai M, et al.Double-phase helical CT of small renal parenchymal neoplasms:correlation with pathologic findings and tumor angiogenesis[J].J Comput Assist Tomogr,2000,24(6):835-842.
[4] Yoshioka K, Miyakawa A, Ohno Y, et al.Production of erythropoietin and multiple cytokines by metanephric adenomaresults in erythrocytosis[J].Pathol Int,2007,57(8):529-536.
[5] 李明娜,朱岩,张炜明,等.后肾腺瘤5例临床及病理学特征分析[J].诊断病理学杂志,2012,19(3):172-174.
[6] Olgac S, Hutchinson B, Tickoo S K, et al.Alpha-methylacyl-CoA racemase as a marker in the differential diagnosis of metanephric adenoma[J].Mod Pathol,2006,19(2):218-224.
[7] Kinney S N, Eble J N, Hes O, et al.Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant nephroblastoma[J].Mod Pathol,2015,28(9):1236-1248.
[8] Yakirevich E, Magi-Galluzzi C, Grada Z, et al.Cadherin 17 is a sensitive and specific marker for metanephric adenoma[J].Am J Surg Pathol,2015,39(4):479-486.
[9] Pinto A, Signoretti S, Hirsch M S, et al.Immunohisto-chemical staining for BRAF V600E supports the diagnosis of metanephric adenoma[J].Histopathology,2015,66(6):901-904.
[10] Azabdaftari G, Alroy J, Banner B F, et al.S100 protein expression distinguishes metanephric adenomas from other renal neoplasms[J].Pathol Res Pract,2008,204(10):719-723.
[11] Udager A M, Pan J, Magers M J,et al.Molecular and immunohistochemical characterization reveals novel BRAF mutations in metanephric adenoma[J].Am J Surg Pathol,2015,39(4):549-557.
[12] Ding Y, Wang C, Li X, et al.Novel clinicopathological and molecular characterization of metanephric adenoma: a study of 28 cases[J].Diagn Pathol,2018,13(1):54.
[13] Chan E, Stohr B A, Croom N A, et al.Molecular characterization of metanephric adenomas beyond BRAF: genetic evidence for potential malignant evolution[J].Histopathology,2020,76(7):1084-1090
[14] 杨文萍, 武海燕, 张文, 等.儿童肾母细胞瘤病理诊断共识[J].中华病理学杂志, 2017, 46(3): 149-154.
[15] 曲渊.乳头状肾细胞癌30例临床病理分析[J].临床与实验病理学志,2014(12):1416-1418.
[16] 晏菲,马燕凌,邓洁, 等.后肾腺瘤16例临床病理观察[J].新乡医学院学报,2016,33(1):34-36.
[17] Renshaw A A, Freyer D R, Hammers Y A.Metastatic metanephric adenoma in a child[J].Am J Surg Pathol,2000,24(4):570-574.

备注/Memo

备注/Memo:
1 通信作者; 2 福建医科大学省立临床医学院 福建省立医院病理科
更新日期/Last Update: 2020-10-20