[1]杨国华 郑圣斌 林彩锋 黄若磊.肿瘤相关成纤维细胞经FGF19/FGFR4信号轴调控结肠癌细胞生长的实验研究[J].福建医药杂志,2020,42(04):136-139.
　YANG Guohua,ZHENG Shengbin,LIN Caifeng,et al.Experimental study on CAF regulating the growth of colorectal cancer through the signal axis of fibroblast growth factor 4/fibroblast growth factor 19[J].FUJIAN MEDICAL JOURNAL,2020,42(04):136-139.
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肿瘤相关成纤维细胞经FGF19/FGFR4信号轴调控结肠癌细胞生长的实验研究()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期数:
2020年04期
页码:
136-139
栏目:
基础研究
出版日期:
2020-08-20

文章信息/Info

Title:
Experimental study on CAF regulating the growth of colorectal cancer through the signal axis of fibroblast growth factor 4/fibroblast growth factor 19
文章编号:
1002-2600(2020)04-0136-04
作者:
杨国华 郑圣斌 林彩锋 黄若磊
福建医科大学省立临床学院 福建省立金山医院普外科(福州 350007)
Author(s):
YANG Guohua;  ZHENG Shengbin;  LIN Caifeng;  HUANG Ruolei.
Department of General Surgery, Provincial Jinshan Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian 350007,China
关键词:
肿瘤相关成纤维细胞;  FGF19;  FGFR4;  结肠癌;  生长
Keywords:
CAF;  FGF19;  FGFR4;  colorectal cancer;  growth
分类号:
R735.3
文献标志码:
B
摘要:
目的 探讨肿瘤相关成纤维细胞(CAF)通过FGFR4/FGF19信号轴调控结直肠癌生长可能机制。方法 将研究对象分为3组,分别是细胞组、细胞+NF组、细胞+CAF组。绘制各组癌细胞生长曲线,采用ELISA法检测细胞外FGF19因子浓度变化。 结果 癌细胞与CAF共培养后,癌细胞生长率明显提高,与其他组比较,差异有统计学意义(P<0.05); 细胞外FGF19因子浓度明显提高,与其他组比较,差异有统计学意义(P<0.05)。结论 CAF通过促进结肠癌细胞自分泌FGF19因子,促进癌细胞分裂生长。
Abstract:
Objective To explore the possible mechanism of cancer associated fibroblast(CAF)regulating the growth of colorectal cancer through the signal axis of fibroblast growth factor 4/fibroblast growth factor 19. Methods The experiment was divided into three groups, including cancer cell group, cancer cell+NF group, cancer cell+CAF group. The growth curve of each group was drawn. The changes of extracellular fibroblast growth factor 19 were detected by ELISA. Results After co-culture of cancer cells with CAF, the growth rate of cancer cells was significantly increased, compared with other groups(P<0.05); the concentration of extracellular fibroblast growth factor 19 was significantly increased, compared with other groups(P<0.05). Conclusion CAF can promote the autocrine of fibroblast growth factor 19 and promote the growth of cancer cells.

参考文献/References:

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更新日期/Last Update: 2020-08-20