[1]张青铃 徐益清 罗友华 许光辉 杨 辉 黄亦琦 刘晓娟吴 珏.基于6个成分含量和特征图谱的复方板蓝根利咽颗粒稠浸膏干燥工艺优选[J].福建医药杂志,2020,42(04):130-133.
 ZHANG Qingling,XU Yiqing,LUO Youhua,et al.Optimization of drying process of Compound Banlangen Liyan Granules thick extract based on determination of six components and characteristic map[J].FUJIAN MEDICAL JOURNAL,2020,42(04):130-133.
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基于6个成分含量和特征图谱的复方板蓝根利咽颗粒稠浸膏干燥工艺优选()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期数:
2020年04期
页码:
130-133
栏目:
基础研究
出版日期:
2020-08-20

文章信息/Info

Title:
Optimization of drying process of Compound Banlangen Liyan Granules thick extract based on determination of six components and characteristic map
文章编号:
1002-2600(2020)04-0130-04
作者:
张青铃1 徐益清2 罗友华13 许光辉1 杨 辉1 黄亦琦1 刘晓娟1吴 珏1
福建中医药大学药学院(福州 350122)
Author(s):
ZHANG QinglingXU YiqingLUO YouhuaXU GuanghuiYANG HuiHUANG YiqiLIU XiaojuanWU Jue.
College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian 350122,China
关键词:
复方板蓝根利咽颗粒 工艺 常压干燥 真空干燥 喷雾干燥 HPLC 特征图谱
Keywords:
Compound Banlangen Liyan Granules process atmospheric drying vacuum drying spray drying HPLC characteristic map
分类号:
R94
文献标志码:
B
摘要:
目的 优选复方板蓝根利咽颗粒稠浸膏的干燥工艺。方法 以HPLC法分别同步测定复方板蓝根利咽颗粒稠浸膏、干膏粉中6个指标成分含量及特征图谱,采用单因素和正交试验法,以特征图谱与原液相似度、19个特征峰折算峰面积比值之和、6个成分平均转移率的综合得分为指标,考察常压干燥、真空干燥、喷雾干燥对干膏粉质量的影响,优选稠浸膏的干燥工艺。结果 3种干燥方法的最优工艺参数分别为:常压干燥的温度60 ℃; 真空干燥的真空度-0.085~-0.095 MPa,温度50 ℃; 喷雾干燥的喷雾空气流量50 m3/h、进气温度145 ℃、送液速率30%。3种干燥方法最优参数的综合得分分别为96.20、100.00、100.07。结论 复方板蓝根利咽颗粒稠浸膏的干燥工艺可选用优选的真空干燥或喷雾干燥。优选的干燥工艺稳定可行,参数科学合理,为该中药制剂的稠浸膏干燥方法提供依据。
Abstract:
Objective To optimize the drying process of Compound Banlangen Liyan Granules thick extract.Methods HPLC method was used to simultaneously determine the contents of six index components and characteristic map compared with the original solution in Compound Banlangen Liyan Granules thick extract and dry cream powder.Single factor and orthogonal test methods were used to optimize the drying process of the thick extract,which took the comprehensive score of the similarity of characteristic maps,the sum of the converted peak area ratios of 19 characteristic peaks and the average transfer rate of 6 components as indicators to investigate the effects of atmospheric drying, vacuum drying and spray drying on the quality of dry paste powder.Results The optimum process parameters of the three drying methods were atmospheric drying temperature 60 ℃; vacuum drying vacuum degree -0.085~-0.095 MPa, temperature 50 ℃; spray drying spray air flow 50 m3/h, the intake air temperature 145 ℃, and the liquid feeding rate 30%. The comprehensive scores of the optimal parameters of the three drying methods were 96.20,100.00 and 100.07,respectively.Conclusion The drying process of the Compound Banlangen Liyan Granules thick extract can be vacuum drying or spray drying.The optimized drying process is stable and feasible, and the parameters are scientific and reasonable, providing a basis for the thick extract drying method of the traditional Chinese medicine preparation.

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备注/Memo

备注/Memo:
基金项目:福建省医学创新课题(2016-CXB-16); 厦门市第二批科技计划(科技惠民)项目(3502Z20164084)1 厦门市医药研究所 厦门市天然药物研究与开发重点实验室; 2 泉州市中医院; 3 通信作者,Email:youhualuo@163.com
更新日期/Last Update: 2020-08-20