[1]郑 田 林 帆.纤维蛋白原与清蛋白比值指数对胃间质瘤危险程度分级的预测价值[J].福建医药杂志,2020,42(04):9-13.
　ZHENG Tian,LIN Fan..Predictive value of fibrinogen-to-albumin ratio index for risk classification of gastric stromal tumor[J].FUJIAN MEDICAL JOURNAL,2020,42(04):9-13.
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纤维蛋白原与清蛋白比值指数对胃间质瘤危险程度分级的预测价值()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期数:
2020年04期
页码:
9-13
栏目:
临床研究
出版日期:
2020-08-20

文章信息/Info

Title:
Predictive value of fibrinogen-to-albumin ratio index for risk classification of gastric stromal tumor
文章编号:
1002-2600(2020)04-0009-05
作者:
郑 田 林 帆1
福建医科大学省立临床医学院 福建省立医院老年科 福建省老年医学中心(福州 350001)
Author(s):
ZHENG Tian;  LIN Fan.
Department of Geriatric Medicine, Fujian Provincial Center for Geriatrics,Fujian Provincial Hospital,Provincial Clinical Medical College of Fujian Medical University,Fuzhou, Fujian 350001, China
关键词:
胃间质瘤;  纤维蛋白原与清蛋白比值指数;  危险程度分级
Keywords:
gastric stromal tumor;  fibrinogen-to-albumin ratio index;  risk classification
分类号:
R735.2
文献标志码:
B
摘要:
目的 探讨纤维蛋白原与清蛋白比值指数(FARI)对胃间质瘤危险程度的预测价值。方法 回顾性收集在本院收治的经外科手术或内镜下切除、术后病理及免疫组化确诊为胃间质瘤的患者共208例。根据术后病理分为低危组和高危组,分析术前临床资料与胃间质瘤危险程度的关系。结果 单因素分析显示,胃间质瘤危险程度组间临床症状、中性分叶核计数、血小板计数、NLR、PLR、清蛋白、纤维蛋白原、FARI、三酰甘油、HDL-C、瘤细胞形态、核分裂象计数、肿瘤大小差异均有统计学意义(P<0.05)。logistic回归分析显示,FARI[OR=1.18; 95%CI(1.03,1.35); P<0.05]及HDL-C[OR=0.18; 95%CI(0.09,0.33); P<0.01]是胃间质瘤危险程度的独立危险因素。受试者工作特征(ROC)曲线分析结果显示,FARI曲线下面积为0.711,最佳界限值为7.86%时,预测胃间质瘤危险程度的灵敏度为0.551,特异度为0.806。结论 FARI可作为胃间质瘤危险程度的独立预测指标,在危险程度分级的早期预测及预后预估中有一定的指导意义。
Abstract:
Objective To investigate the value of fibrinogen-to-albumin ratio index(FARI)in predicting the risk classification of gastric stromal tumor.Methods A total of 208 patients with gastric stromal tumor diagnosed by postoperative pathology and immunohistochemistry after surgical or endoscopic resection were collected retrospectively.According to postoperative pathology, the patients were divided into low risk group and high risk group, and the relationship between preoperative clinical data and the risk of gastric stromal tumor was analyzed.Results Single factor analysis showed that the differences of clinical symptoms, neutral points leaf nuclear count, platelet count, NLR, PLR, albumin, fibrinogen, FARI, triglyceride, high-density lipoprotein cholesterol,tumor cell morphology, fission like counting, tumor size had statistical significance(P<0.05)between the two groups.Logistic regression analysis showed that FARI[OR=1.18; 95%CI(1.03,1.35); P<0.05] and HDL-C[OR=0.18; 95%CI(0.09,0.33); P<0.01] were independent risk factors for the risk degree of gastric stromal tumor.The ROC curve analysis showed that when the area under the FARI curve was 0.711 and the optimal threshold value was 7.86%, the sensitivity and specificity for predicting the risk of gastric stromal tumor were 0.551 and 0.806.Conclusion FARI can be used as an independent predictor of the risk degree of gastric stromal tumors,and has a certain guiding significance in the early prediction of risk classification and prognosis prediction.

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备注/Memo

备注/Memo:
基金项目:福建医科大学启航基金(2017XQ1140)1 通信作者,福建省立医院干部特诊二科
更新日期/Last Update: 2020-08-20