[1]李 滨 欧阳秋芳 陈美华 王 永 郭进建.二维斑点追踪技术评价健心颗粒对糖尿病心肌病患者左室功能的影响[J].福建医药杂志,2020,42(02):20-24.
　LI Bin,OUYANG Qiufang,CHEN Meihua,et al.Effect of jianxin granules on left ventricular function in patients with diabetic cardiomyopathy was evaluated by two-dimensional spot tracking technique[J].FUJIAN MEDICAL JOURNAL,2020,42(02):20-24.
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二维斑点追踪技术评价健心颗粒对糖尿病心肌病患者左室功能的影响()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期数:
2020年02期
页码:
20-24
栏目:
临床研究
出版日期:
2020-04-15

文章信息/Info

Title:
Effect of jianxin granules on left ventricular function in patients with diabetic cardiomyopathy was evaluated by two-dimensional spot tracking technique
文章编号:
1002-2600(2020)02-0020-05
作者:
李 滨 欧阳秋芳 陈美华 王 永 郭进建1
福建中医药大学附属第二人民医院心血管内科(福州 350001)
Author(s):
LI Bin; OUYANG Qiufang; CHEN Meihua;  WANG Yong; GUO Jinjian.
Department of cardiology, the Second Peoples Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou,Fujian 350001, China
关键词:
健心颗粒;  糖尿病心肌病;  斑点追踪技术;  心功能
Keywords:
jianxin granules;  diabetic cardiomyopathy;  spot tracking technology;  cardiac function
分类号:
R587.1; R540.4+5
文献标志码:
A
摘要:
目的 采用二维斑点追踪技术评价健心颗粒对糖尿病心肌病(DCM)患者心室功能的影响。方法 选择2017年1月至2019年12月于本院心血管内科新确诊的80名DCM患者为研究对象,分为观察组和对照组,每组40例,两组均给予常规西药治疗方案,观察组在此基础上给予健心颗粒,两组疗程为1个月。比较两组患者在治疗前后临床症状、收缩压、舒张压、左室收缩期整体长轴峰值应变、整体圆周峰值应变、左室射血分数、NT-proBNP等指标变化情况。结果 观察组临床疗效总有效率(85.0%)明显高于对照组(60.0%)。治疗后,两组空腹血糖及NT-proBNP均显著减低,但观察组NT-proBNP、射血分数、左室收缩期整体长轴(圆周、径向)峰值应变改善情况明显大于对照组。两组间LA、LVDd、IVSd、LVPWd、E/A治疗前后差异无统计学意义(P>0.05)。结论 健心颗粒在改善DCM左室结构前,已明显改善其心室功能; 二维斑点追踪技术能够早期准确地对治疗效果进行评价,值得临床推广及应用。
Abstract:
Objective The effect of jianxin granules on ventricular function in patients with diabetic cardiomyopathy(DCM)was evaluated by two-dimensional spot tracking technique.Methods A total of 80 newly diagnosed DCM patients from the department of cardiology, the Second Peoples Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January 2017 to December 2019 were selected as subjects.They were divided into the experimental group and the control group, with 40 participants in each group.Both groups were given the conventional western medicine treatment plan, and the experimental group was given jianxin granules on this basis.The treatment course of the two groups was 1 month.The changes of clinical symptoms, systolic blood pressure, diastolic blood pressure, left ventricular systolic overall long-axis peak strain, overall peripheral peak strain, left ventricular ejection fraction, nt-probnp and other indicators in the two groups before and after treatment were compared.Results The total effective rate(85.0%)of the experimental group was significantly higher than that of the control group(60.0%).After treatment, fasting glucose and nt-probnp were significantly reduced in both groups, but the experimental group nt-probnp, ejection fraction, left ventricular systolic overall long axis(circumference, radial)peak strain improvement was significantly greater than the control group.There were no significant differences in LA, LVDd, IVSd, LVPWd and E/A between the two groups before and after treatment.Conclusion Before improving the left ventricular structure of DCM, jianxin granules had significantly improved its ventricular function.The two-dimensional spot tracking technology can accurately evaluate the treatment effect in the early stage, which is worthy of clinical promotion and application.

参考文献/References:

[1] 赵航,冯景辉,吴秀萍.糖尿病心肌病发病机制的研究进展[J].国际心血管病杂志,2016,43(1):16-18.
[2] 孙晓慧,牟艳玲.糖尿病心肌病血清标志物的研究进展[J].山东医药杂志,2015,55(41):96-98.
[3] 顾晓明,郑文静,李冠群,等.葛芪合剂对糖尿病心肌病患者心室重构的干预研究[J].中西医结合心脑血管病杂志,2014,12(5):563-565.
[4] 刘江燕,芦芳.斑点追踪显像技术评价糖尿病心肌病患者左心室功能研究进展[J].中华医学超声杂志:电子版,2016,13(10):797-800.
[5] 郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国中医药科技出版社,2002:77-85.
[6] 陶延丽,戴小华.中医药防治糖尿病心肌病研究进展[J].中医药临床杂志,2014,26(1):83-85.
[7] 马红,谢明星,王新房,等.超声斑点追踪成像评价2型糖尿病患者左心室收缩功能早期改变[J].中华超声影像学杂志2009,18(2):96-100.

备注/Memo

备注/Memo:
基金项目:第四批全国中医优秀人才项目(国中医药办人教发[2017]24号); 国家自然科学基金(81973916); 福建省卫生计生中青年骨干人才培养项目(2018-ZQN-71); 福建省自然科学基金(2019J01480)。第一作者:李滨,医学硕士,中西医结合医师。1 通信作者:郭进建,医学博士,主任医师,Email:eguojj@163.com
更新日期/Last Update: 2020-04-15