[1]郭慈仁 林 洁 石怀景 陈桂林 江信燕.嗜神经侵袭与宫颈癌根治术后远处转移的关系[J].福建医药杂志,2019,41(06):16-18.
　GUO Ciren,LIN Jie,SHI Huaijing,et al.Relationship between perineural invasion and distant metastasis of cervical cancer after radical operation[J].FUJIAN MEDICAL JOURNAL,2019,41(06):16-18.
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嗜神经侵袭与宫颈癌根治术后远处转移的关系()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
41
期数:
2019年06期
页码:
16-18
栏目:
临床研究
出版日期:
2019-12-25

文章信息/Info

Title:
Relationship between perineural invasion and distant metastasis of cervical cancer after radical operation
文章编号:
1002-2600(2019)06-0016-04
作者:
郭慈仁 林 洁1 石怀景 陈桂林 江信燕
福建医科大学附属肿瘤医院 福建省肿瘤医院妇科(福州 350014)
Author(s):
GUO Ciren;  LIN Jie; SHI Huaijing; CHEN Guilin;  JIANG Xinyan.
Department of Tumor Gynecology, Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fuzhou,Fujian 350014, China
关键词:
宫颈肿瘤;  嗜神经侵袭;  远处转移
Keywords:
cervical neoplasm;  perineural invasion;  distant metastasis
分类号:
R737.33
文献标志码:
B
摘要:
目的 探讨嗜神经侵袭(perineural invasion,PNI)在宫颈癌中的发生情况及其与术后远处转移的关系。方法 回顾性分析2014年2月至2017年8月在我院行广泛性全子宫切除加盆腔淋巴结清扫术的Ⅰb～Ⅱb期157例宫颈癌患者的临床资料,观察PNI的发生情况,并分析PNI与各临床病理因素及术后远处转移的关系。结果 1)157例宫颈癌患者中有19例发生PNI,阳性率为12.1%; 2)宫颈癌PNI的发生与淋巴结转移、脉管癌栓、宫旁浸润及深肌层浸润明显相关(均P<0.05),而与年龄、肿瘤直径、临床分期、组织学类型、组织学分级及阴道切缘无关(均P>0.05); 3)PNI阳性患者的术后远处转移率(15.8%)明显高于PNI阴性者(3.6%),两者间差异有统计学意义(P<0.05)。结论 宫颈癌存在PNI现象,其发生与术后远处转移密切相关,有望成为判断宫颈癌预后的一个新指标。
Abstract:
Objective To investigate the occurrence of perineural invasion(PNI)in cervical cancer and its relationship with distant metastasis after radical operation.Methods A total of 157 cases of patients with cervical cancer(stage Ⅰb-Ⅱb)who underwent radical hysterectomy and pelvic lymphadenectomy from Feb 2014 to Aug 2017 were retrospectively analyzed.The occurrence of PNI was observed and its relationships with clinicopathological characteristics and distant metastasis after radical operation were analyzed.Results The positive rate of PNI was 12.1%(19/157).PNI had a significant association with lymph nodes metastases, lymphoma vascular space invasion, parametrical invasion and depth of invasion(P<0.05), but had nothing to do with patient age, tumor size, FIGO stage, pathological type, histological grade and vaginal margin(P>0.05).Postoperative distant metastasis rate of PNI positive patients(15.8%)was significantly higher than that of PNI negative patients(3.6%),and there was a significant difference between the two groups.Conclusion PNI exists in cervical cancer, and its occurrence is closely related to distant metastasis after operation.It is expected to become a new index to judge the prognosis of cervical cancer after operation.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:福建省自然科学基金项目(2016J01505)
更新日期/Last Update: 2019-12-25