[1]郑 竑 陈学生 林 伟.TiO2纳米管阵列/介孔羟基磷灰石复合型药物载体的构建及药物缓释研究[J].福建医药杂志,2019,41(03):8-11.
　ZHENG Hong,CHEN Xuesheng,LIN Wei..Construction and drug sustained release of TiO2 nanotube array/mesoporous hydroxyapatite composite drug carrier[J].FUJIAN MEDICAL JOURNAL,2019,41(03):8-11.
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TiO2纳米管阵列/介孔羟基磷灰石复合型药物载体的构建及药物缓释研究()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
41
期数:
2019年03期
页码:
8-11
栏目:
临床研究
出版日期:
2019-02-20

文章信息/Info

Title:
Construction and drug sustained release of TiO2 nanotube array/mesoporous hydroxyapatite composite drug carrier
文章编号:
1002-2600(2019)03-0008-04
作者:
郑 竑 陈学生 林 伟1
福建省福州市第二医院骨科(福州 350007)
Author(s):
ZHENG Hong; CHEN Xuesheng; LIN Wei.
Department of Orthopaedics,Fuzhou Municipal Second Hospital, Fuzhou,Fujian 350007,China
关键词:
骨科钛板;  TiO2纳米管阵列;  介孔羟基磷灰石;  阿仑磷酸钠;  缓释
Keywords:
orthopedic titanium plate;  TiO2 nanotube array;  mesoporous hydroxyapatite;  alendronate sodium;  sustained release
分类号:
R68
文献标志码:
A
摘要:
目的 构建一种骨科钛板表面TiO2纳米管阵列/介孔羟基磷灰石(m-HA)复 合型药物载体,考察阿仑膦酸钠(ALN)在其上的缓释性能。方法 利用X射线衍射(XRD)、扫描电镜 (SEM)、透射电镜(TEM)分别表征TiO2纳米管阵列及TiO2纳米管阵 列/m-HA复合型药物载体的形貌,并测定其上负载ALN的缓释。结果 成功构建了稳定的 TiO2纳米管阵列/m-HA复合型药物载体,相对于TiO2纳米管阵列具有更 大的药物担载量。同时负载在TiO2纳米管阵列中的ALN在第3 d时释放量即达 (88.06±6.27)%,从第5 d开始,药物释放基本完毕,8 d后的总释放率为 (94.91±8.51)%; 负载在TiO2纳米管阵列/m-HA复合型药物载体中的ALN在第3 d时的释放量仅为(66.51±5.37)%,且在后续的几天里保持持续缓慢释放药物,8 d后总释放 率达到(97.31±8.22)%。结论 TiO2纳米管阵列/m-HA复合型药物载体比单纯的 TiO2纳米管阵列具有更大的药物担载量,同时缓释性能更好。
Abstract:
Objective To construct a TiO2 nanotube array/mesoporous hydroxyapatite(m-HA)composite drug carrier on the surface of orthopedic titanium plate, and investigate the sustained release of alendronate sodium(ALN)on its performance.Methods X-ray diffraction(XRD), scanning electron microscopy(SEM)and transmission electron microscopy(TEM)were used to characterize the morphology of TiO2 nanotube array and TiO2 nanotube array/m-HA composite drug carriers.The sustained release of the loaded ALN was measured.Results Stable TiO2 nanotube array/m-HA composite drug carriers were successfully constructed, which had a larger drug loading capacity than the TiO2 nanotube array.The release rate of ALN loaded on the TiO2 nanotube array at the 3rd days was(88.06±6.27)%, the drug release was almost completed from the 5th day, and the total release rate after eight days was(94.91±8.51)%.The release rate of ALN loaded on the TiO2 nanotube array/m-HA composite drug carriers was only(66.51±5.37)% at the 3rd days, the sustained release of the drug continued for the next few days, and the total release rate reached (97.31±8.22)% after eight days.Conclusion The TiO2 nanotube array/m-HA composite drug carrier has a larger drug loading than the pure TiO2 nanotube array, and the sustained release performance is better.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:2018年福建省自然科学基金面上项目(2018J01357) 1 通信作者,Email:linwei_fj@126.com
更新日期/Last Update: 2019-02-20