[1]李 敏 陈 锋 王建伟.联合检测心型脂肪酸结合蛋白、和肽素及肌钙蛋白T对非ST 段抬高型急性心梗的早期诊断价值[J].福建医药杂志,2018,40(06):25-28.
　LI Min,CHEN Feng,WANG Jianwei..Diagnostic value of the combination of heart-type fatty acid-binding protein,copeptin and cardiac troponin T in patients with non-ST-segment elevation myocardial infarction[J].FUJIAN MEDICAL JOURNAL,2018,40(06):25-28.
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联合检测心型脂肪酸结合蛋白、和肽素及肌钙蛋白T对非ST 段抬高型急性心梗的早期诊断价值()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
40
期数:
2018年06期
页码:
25-28
栏目:
临床研究
出版日期:
2018-11-29

文章信息/Info

Title:
Diagnostic value of the combination of heart-type fatty acid-binding protein,copeptin and cardiac troponin T in patients with non-ST-segment elevation myocardial infarction
文章编号:
1002-2600(2018)06-0025-04
作者:
李 敏 陈 锋1 王建伟2
福建医科大学省立临床医学院 福建省立医院急诊科(福州 350001)
Author(s):
LI Min; CHEN Feng; WANG Jianwei.
Department of Emergency, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou,Fujian 350001, China
关键词:
心型脂肪酸结合蛋白;  和肽素;  肌钙蛋白T;  非ST段抬高型心肌梗死
Keywords:
H-FABP;  copeptin;  cTnT;  NSTEMI
分类号:
R542.2
文献标志码:
B
摘要:
目的 研究心型脂肪酸结合蛋白(H-FABP)、和肽素(copeptin)与肌钙蛋白T(cTnT)联合检测对非ST段抬高型心肌梗死(NSTEMI)早期诊断的价值。方法 收集急诊胸痛患者111例,均于胸痛3 h内入院,其中非ST段抬高型急性心梗(NSTEMI)58例、心绞痛(AP)22例、非心源性胸痛(NCCP)31例,检测血清H-FABP、和肽素、cTnT、肌钙蛋白I(cTnI)、肌酸激酶同工酶(CKMB),比较组间差异。NSTEMI患者按照Gensini评分分为低分组14例,中分组19例,高分组25例,比较上述指标的组间差异。根据ROC曲线判断各指标对NSTEMI早期诊断的效能。结果 联合检测H-FABP、和肽素与cTnT在NSTEMI早期诊断中有着较高的敏感度(71.1%)及特异度(72.6%),曲线下面积为0.729,高于cTnT、 cTnI及 CKMB(P<0.05)。结论 联合检测H-FABP、和肽素与cTnT对NSTEMI的早期诊断效能优于cTnT、cTnI及CKMB,也对冠脉病变程度的评估具有一定临床指导意义。
Abstract:
Objective To study the prognostic value of the combination of heart-type fatty acid-binding protein(H-FABP), copeptin and cardiac troponin T(cTnT)in patients with non-ST-segment elevation myocardial infarction(NSTEMI).Methods A total of 111 patients treated in our department due to chest pain within three hours were recruited, including 58 cases of NSTEMI, 22 cases of AP and 31 cases of NCCP. H-FABP,copeptin,cTnT,cTnI and CKMB were measured in all patients.According to Gensini scoring system for quantitative determination of each vascular lesions, the patients with NSTEMI were divided into three groups: low score group(14 cases),middle score group(19 cases),and high score group(25 cases).According to ROC curve, the efficacy of each index in the early diagnosis of NSTEMI was determined. Results The combination of H-FABP, copeptin and cTnT showed higher detection sensitivity(71.1%),specificity(72.6%).The AUC of joint detection increased significantly(P<0.05)compared to that of cTnT,cTnI and CKMB. Conclusion The combination of H-FABP, copeptin and cTnT shows better diagnosis efficiency of NSTEMI than cTnT,cTnI and CKMB, and also reflects the severity of coronary artery disease.

参考文献/References:

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备注/Memo

备注/Memo:
通信作者,Email: cf9066@126.com; 2 福建省立医院南院检验科
更新日期/Last Update: 2018-11-29