[1]宋立罡,许尚文.海马体积自动分割在内侧颞叶癫痫中的价值[J].福建医药杂志,2025,47(03):1-4.[doi:10.20148/j.fmj.2025.03.001]
　SONG Ligang,XU Shangwen.The value of automatic segmentation of hippocampal volume in medial temporal lobe epilepsy[J].FUJIAN MEDICAL JOURNAL,2025,47(03):1-4.[doi:10.20148/j.fmj.2025.03.001]
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海马体积自动分割在内侧颞叶癫痫中的价值()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
47
期数:
2025年03期
页码:
1-4
栏目:
临床研究
出版日期:
2025-03-20

文章信息/Info

Title:
The value of automatic segmentation of hippocampal volume in medial temporal lobe epilepsy
文章编号:
1002-2600(2025)03-0001-04
作者:
宋立罡; 许尚文
福建中医药大学福总教学医院(第九〇〇医院),福州 350025
Author(s):
SONG Ligang;  XU Shangwen
Fuzong Teaching Hospital of Fujian University of Traditional Chinese Medicine(900th Hospital), Fuzhou, Fujian 350025, China
关键词:
内侧颞叶癫痫;  海马亚区;  磁共振成像;  自动脑分割
Keywords:
medial temporal lobe epilepsy;  hippocampal subregions;  MRI;  automatic brain segmentation
分类号:
R742.1
DOI:
10.20148/j.fmj.2025.03.001
文献标志码:
B
摘要:
目的 通过表面结构分割技术测量海马亚区体积,并对比内侧颞叶癫痫(MTLE)患者与健康人群的海马亚区体积差异,以评估亚区体积特征对癫痫预后的价值。方法 基于中国人民解放军联勤保障部队第九〇〇医院癫痫数据库搜集2011年1月至2024年12月经临床诊断为颞叶癫痫的患者,根据纳排标准最终纳入患者127例、健康对照志愿者98例的MRI资料,所有受试者均在3.0T磁共振上采集图像,利用uAI Discover-Brain即NR脑结构智能分析系统(20240430-release-hotx4)自动分割各脑区并自动测量各脑区的体积。结果 MTLE患者在双侧海马前下托、旁下托、下托、CA1区、CA3区、CA4区、DG、海马分子层、海马尾、海马裂(P<0.001)、右海马杏仁核过渡区(P=0.021)、左海马伞(P<0.001)、右海马伞(P=0.008)等多个亚区较健康对照组出现萎缩。发病年龄、癫痫持续时间、是否发生过脑膜炎、脑外伤及高热惊厥,均非预后结局的影响因素(P>0.05)。右侧MTLE 患者预后与左海马伞体积呈正相关(P=0.002),左侧MTLE患者和同侧海马总体积(P=0.002)、内嗅皮质(P=0.04)、双侧海马旁回体积相关(左侧P=0.009、右侧P=0.013)相关。结论 MTLE患者海马总体积、海马伞、内嗅皮质及双侧海马旁回体积与预后结局相关,且左右侧癫痫患者的亚区改变不同,说明识别海马亚区的萎缩,可以更好地预测患者的预后。
Abstract:
Objective By measuring the hippocampal subregion volumes with surface structure segmentation technique and comparing hippocampal subregion volume differences between patients with medial temporal lobe epilepsy and the healthy population, the research aims to evaluate the value of subregion volume characteristics for the prognosis of epilepsy. Methods We collected data from patients diagnosed with temporal lobe epilepsy(TLE)from January 2011 to December 2024 based on the epilepsy database of The 900th Hospital of Joint Logistic Support Force, PLA. A total of 127 patients and 98 healthy control vo-lunteers were included according to the inclusion and exclusion criteria, and their MRI data were analyzed. All subjects underwent imaging on a 3.0 T magnetic resonance scanner. The uAI Discover-Brain, an NR brain structure intelligent analysis system(20240430-release-hotx4), was used to automatically segment and measure the volumes of various brain regions. Results Patients with mesial temporal lobe epilepsy(MTLE)exhibited atrophy in multiple subregions compared with healthy controls, including the bilateral hippocampal presubiculum, parasubiculum, subiculum, CA1, CA3, CA4, dentate gyrus(DG), hippocampal molecular layer, hippocampal tail, and hippocampal fissure(P<0.001), the right hippocampal-amygdaloid transition area(P=0.021), the left hippocampal fimbria(P<0.001), and the right hippocampal fimbria(P=0.008).The duration of epilepsy,age of onset,and medical history of febrile seizures,meningitis,or traumatic brain injury were not associated with the prognosis outcomes(P>0.05).In patients with right MTLE, prognosis was positively correlated with the volume of the left hippocampal fimbria(P=0.002). In patients with left MTLE, prognosis was correlated with the ipsilateral hippocampal total volume(P=0.002), entorhinal cortex(P=0.04), and bilateral parahippocampal gyrus volume(left P=0.009, right P=0.013). Conclusion The prognosis of MTLE patients is correlated with total hippocampal volume, hippocampal fimbria, entorhinal cortex, and the volume of the bilateral parahippocampal gyrus. Moreover, the changes in subregions differ between patients with left-sided and right-sided epilepsy. This suggests that identifying atrophy in hippocampal subregionscan better predict patient outcomes.

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备注/Memo

备注/Memo:
基金项目:福建省自然科学基金(2023Y0066); 福建省科技厅科技创新联合资金项目(2024Y9647)
通信作者:许尚文,Email:xu_swen@163.com
更新日期/Last Update: 2025-03-20