[1]康靖,房涛,倪宇君.基于自动纤维定量技术分析孤独症谱系障碍患者白质纤维束改变[J].福建医药杂志,2024,46(05):1-5.[doi:10.20148/j.fmj.2024.05.001]
　KANG Jing,FANG Tao,NI Yujun.Analysis of white matter fiber bundle changes in autism spectrum disorder patients based on automated fiber quantitative technology[J].FUJIAN MEDICAL JOURNAL,2024,46(05):1-5.[doi:10.20148/j.fmj.2024.05.001]
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基于自动纤维定量技术分析孤独症谱系障碍患者白质纤维束改变()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期数:
2024年05期
页码:
1-5
栏目:
临床研究
出版日期:
2024-10-15

文章信息/Info

Title:
Analysis of white matter fiber bundle changes in autism spectrum disorder patients based on automated fiber quantitative technology
文章编号:
1002-2600(2024)05-0001-05
作者:
康靖; 房涛; 倪宇君
福建省福州市第一总医院儿童专科院区放射科,福州350001
Author(s):
KANG Jing;  FANG Tao;  NI Yujun
Department of Radiology, Fuzhou First General Hospital Pediatric Campus, Fuzhou, Fujian 350001, China
关键词:
孤独症谱系障碍;  弥散张量成像;  自动纤维定量技术
Keywords:
autism spectrum disorder;  diffusion tensor imaging;  automated fiber quantification
分类号:
R749.94; R445.2
DOI:
10.20148/j.fmj.2024.05.001
文献标志码:
A
摘要:
目的 采用自动纤维定量技术(AFQ)分析孤独症谱系障碍(ASD)患者大脑白质纤维束的特征,探索其在ASD患者中的应用价值及ASD患者白质纤维束的改变。方法 自闭症脑成像数据库(ABIDE)公共数据集中Trinity Centre for Health Sciences的20名ASD患者和20名性别、年龄、惯用手与之相匹配的健康对照组均进行了磁共振弥散张量成像(DTI)扫描,采用AFQ技术自动提取大脑主要纤维束并分段,对纤维束均值和纤维束分段逐点进行组间比较,分析ASD患者白质纤维束改变。结果(1)在纤维束平均值组间比较中,成功追踪的18条纤维束DTI指标均值组间差异无统计学意义;(2)在纤维束逐点比较中,ASD纤维束在右侧皮质脊髓束(CST)、双侧上纵束(SLF)及左侧弓形束(AF)与健康对照组比较,差异均有统计学意义[多重比较矫正(FDR)后P<0.05],表现为节段性的各向异性分数(FA)减低、平均扩散系数(MD)和径向扩散系数(RD)增高。结论 AFQ可能有助于在疾病早期发现神经纤维束中的细小差异; ASD患者多条神经纤维束与正常人存在显著差异,这些白质纤维束的改变可能是造成ASD患者临床表现复杂而多样的基础。
Abstract:
Objective To analyze the characteristics of white matter fiber tracts in the brains of patients with autism spectrum disorder(ASD)by employing automated fiber quantification(AFQ)technology, and explore its application value in identifying changes in the white matter fiber tracts of ASD patients. Methods Twenty ASD patients from the Trinity Centre for Health Sciences in the Autism Brain Imaging Data Exchange(ABIDE)public dataset and 20 healthy controls matched by gender, age, and handedness underwent magnetic resonance diffusion tensor imaging(DTI)scans. AFQ was used to automatically extract and segment the major fiber tracts of the brain, separately extract the mean of DTI parameters within each fiber tract and each segment. One-way ANOVA(Analysis of Variance)and the Mann-Whitney U test were utilized to compare the differences in the mean of DTI parameters within fiber tracts and segments between the two groups. Results(1)In the inter-group comparison of fiber tracts, no significant differences were observed in DTI parameters means of the 18 fiber tracts;(2)In the inter-group comparison of fiber tract segmentations, significant differences were found between the two groups in the right corticospinal tract(CST), bilateral superior longitudinal fasciculus(SLF), and left arcuate fasciculus(AF)(after FDR correction P<0.05), characterized by segmental reduction in fractional anisotropy(FA)values and increases in mean diffusivity(MD)values and radial diffusivity(RD)values in ASD fiber tract. However, there were no significant differences in AD values between the two groups. Conclusions AFQ may help to detect subtle differences in nerve fiber tracts at an early stage of the disease.There are significant differences in multiple nerve fiber tracts between ASD patients and normal individuals, and these changes in white matter fiber tracts may be the basis for the complex and diverse clinical manifestations in ASD patients.

参考文献/References:

[1] APA. Diagnostic and statistical manual of mental disorders[M].Fifth Edition. Washington, DC: American Psychiatric Association,2013.
[2] KIM S H,BAL V H,LORD C.Longitudinal follow-up of academic achievement in children with autism from age 2 to 18[J].Journal of Child Psychology and Psychiatry,2018,59(3):258-267.
[3] CURTIN C,HUBBARD K,ANDERSON S E,et al.Food selectivity, mealtime behavior problems, spousal stress,and family food choices in children with and without autism spectrum disorder[J].Journal of Autism and Developmental Disorders,2015,45(10):3308.
[4] REICHOW B, HUME K, BARTON E E,et al. Early intensive behavioral intervention(EIBI)for young children with autism spectrum disorders(ASD)[J].Cochrane Database Syst Rev,2018,5(5):CD009260.
[5] YEATMAN J D, DOUGHERTY R F, MYALL N J,et al.Tract profiles of white matter properties: Automating fiber-tract quantification[J].PLoS One,2012,7(11):e49790.
[6] 戴珂,陆加明,李卫萍,等.基于扩散张量成像自动纤维定量分析的轻度认知障碍的分类预测研究[J].临床放射学杂志,2022,41(1):23-29.
[7] 张鹏,夏建国,张继,等.基于自动纤维定量分析系统性红斑狼疮患者白质纤维束改变与其认知功能障碍的相关性[J].中国医学影像技术,2023,39(8):1171-1175.
[8] WU Y,GU L,HONG S,et al. Altered white matter microstructure in herpes zoster and postherpetic neuralgia determined by automated fiber quantification[J]. Brain Sci,2022,12(12):1668.
[9] 章捷,路俊锋,吴劲松,等.弓状束纤维示踪与功能磁共振成像定位额叶语言皮质的比较研究[J].中华神经外科杂志,2012,28(12):4.
[10] CHANG E F,RAYGOR K P,BERGER M S.Contemporary model of language organization: An overview for neurosurgeons[J].Journal of Neurosurgery,2014,122(2):1-12.
[11] VERGANI F,GHIMIRE P,RAJASHEKAR D,et al.Superior longitudinal fasciculus(SLF)I and II:an anatomical and functional review[J].Journal of Neurosurgical Sciences,2021,65(6):560-565.
[12] MARTINO J,WITT HAMER P C,BERGER M S,et al.Analysis of the subcomponents and cortical terminations of the perisylvian superior longitudinal fasciculus: a fiber dissection and DTI tractography study[J].Brain Structure & Function,2013,218(1):105-121.

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备注/Memo

备注/Memo:
基金项目:福州市临床重点专科建设项目(20220101)
更新日期/Last Update: 2024-10-15