[1]杨燕芬,杨舒萍,林丽卿,等.无创压力-应变环评估冠心病合并高尿酸血症患者的心肌做功[J].福建医药杂志,2024,46(03):1-4.[doi:10.20148/j.fmj.2024.03.001]
　YANG Yanfen,YANG Shuping,LIN Liqing,et al.Non-invasive pressure-strain loop assessment of myocardial work in patients with coronary heart disease complicated with hyperuricemia[J].FUJIAN MEDICAL JOURNAL,2024,46(03):1-4.[doi:10.20148/j.fmj.2024.03.001]
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无创压力-应变环评估冠心病合并高尿酸血症患者的心肌做功()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期数:
2024年03期
页码:
1-4
栏目:
临床研究
出版日期:
2024-06-15

文章信息/Info

Title:
Non-invasive pressure-strain loop assessment of myocardial work in patients with coronary heart disease complicated with hyperuricemia
文章编号:
1002-2600(2024)03-0001-04
作者:
杨燕芬1; 杨舒萍2; 林丽卿2; 陈荣荣2; 黄淑铉1; 吴珠娥1; 佘火标2
1 福建医科大学临床医学部,福州 350122; 2 福建医科大学附属漳州市医院, 漳州 363000
Author(s):
YANG Yanfen1; YANG Shuping2; LIN Liqing2; CHEN Rongrong2; HUANG Shuxuan1; WU Zhue1; SHE Huobiao2
1 School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian 350122, China; 2 Zhangzhou Affiliated Hospital of Fujian Medical Univesity, Zhangzhou, Fujian 363000, China
关键词:
压力-应变环;  冠心病;  高尿酸血症;  心肌做功
Keywords:
pressure-strain loop;  coronary artery disease;  hyperuricemia;  myocardial work
分类号:
R445.1; R541.4
DOI:
10.20148/j.fmj.2024.03.001
文献标志码:
B
摘要:
目的 应用无创压力-应变环(PSL)评估冠心病合并高尿酸血症患者的心肌做功情况。方法 回顾性分析2021年12月至2022年12月入住我院心内科行数字减影血管造影(DSA)确诊冠心病的119名患者,记录患者血清尿酸基线水平,根据血清尿酸水平分为高尿酸组(n=38)和正常尿酸组(n=81),两组均接受常规超声心动图检查并应用EchoPAC软件,输入血压值构建左心室PSL,获得心肌做功参数,包括整体做功指数(GWI)、整体有效做功(GCW)、整体无效做功(GWW)、整体做功效率(GWE),GWE=GCW/(GCW+GWW),比较各组上述参数的差异及与血清尿酸之间的相关性和回归性。结果 两组的GWI和GCW比较差异均有统计学意义(均P<0.05),高尿酸组的GWI和GCW均减小; Pearson相关分析表明,GWI、GCW与血尿酸值呈负相关(r=-0.255、-0.242,P<0.05)。线性回归分析表明,左室心肌做功值与冠心病患者的血清尿酸值存在线性相关。结论 无创压力-应变环可以量化高尿酸水平对冠心病患者的心肌损害情况,为临床提供指导价值。
Abstract:
Objective To evaluate myocardial work in patients with coronary heart disease(CHD)complicated with hyperuricemia using non-invasive pressure-strain loops(PSL). Methods A retrospective analysis was conducted on 119 patients with CHD who were admitted to the cardiology department of our hospital and diagnosed with digital subtraction angiography(DSA)from December 2021 to December 2022. The baseline serum uric acid levels of the patients were recorded, and they were divided into a high uric acid group(n=38)and a normal uric acid group(n=81)based on their serum uric acid levels. Both groups underwent routine echocardiography and utilized the EchoPAC software to construct left ventricle PSL by inputting blood pressure values. Myocardial work parameters were obtained, including global work index(GWI), global constructive work(GCW), global wasted work(GWW), and global work efficiency(GWE).GWE=GCW/(GCW+GWW). The differences in these parameters between the groups, as well as their correlation and regression with serum uric acid, were compared. Results There were statistically significant differences in GWI and GCW between the two groups(both P<0.05). Both GWI and GCW were reduced in the high uric acid group. Pearson correlation analysis showed that GWI and GCW were negatively correlated with serum uric acid values(r=-0.255,-0.242,P<0.05). Linear regression analysis showed a linear correlation between left ventricular myocardial work values and serum uric acid levels in patients with CHD. Conclusion Non-invasive pressure-strain loops can quantify the myocardial damage caused by high uric acid levels in patients with CHD, thus providing clinical guidance.

参考文献/References:

[1] MORONI F, GERTZ Z, AZZALINI L.Relief of ischemia in ischemic cardiomyopathy [J]. Curr Cardiol Rep, 2021, 23(7): 80.
[2] ROTH G A, MENSAH G A, FUSTER V.The global burden of cardiovascular diseases and risks: a compass for global action [J]. J Am Coll Cardiol, 2020, 76(25): 2980-2981.
[3] ZHANG S, WANG Y, CHENG J, et al.Hyperuricemia and cardiovascular disease [J]. Curr Pharm Des, 2019, 25(6): 700-709.
[4] BOE E, SKULSTAD H, SMISETH O A.Myocardial work by echocardiography: a novel method ready for clinical testing [J]. Eur Heart J Cardiovasc Imaging, 2019, 20(1): 18-20.
[5] 沈迎, 张瑞岩, 沈卫峰.稳定性冠心病血运重建策略进展——2018中国稳定性冠心病诊断与治疗指南解读 [J]. 心脑血管病防治, 2019, 19(2): 107-111.
[6] PADDA J, KHALID K, ALMANIE A H, et al.Hyperurice-mia in patients with coronary artery disease and its association with disease severity [J]. Cureus, 2021, 13(8): e17161.
[7] POLLACK C V, ANTMAN E M, HOLLANDER J E.2007 focused update to the ACC/AHA guidelines for the management of patients with st-segment elevation myocardial infarction: implications for emergency department practice [J]. Annals of Emergency Medicine, 2008, 52(4): 344-355.e1.
[8] PRZEWLOCKA-KOSMALA M, MARWICK T H, MYSIAK A, et al.Usefulness of myocardial work measurement in the assessment of left ventricular systolic reserve response to spironolactone in heart failure with preserved ejection fraction [J]. Eur Heart J Cardiovasc Imaging, 2019, 20(10): 1138-1146.
[9] SAITO Y, TANAKA A, NODE K, et al.Uric acid and cardiovascular disease: A clinical review [J]. J Cardiol, 2021, 78(1): 51-57.
[10] TIMOTEO A T, LOUSINHA A, LABANDEIRO J, et al.Serum uric acid: a forgotten prognostic marker in acute coronary syndromes?[J]. Eur Heart J Acute Cardiovasc Care, 2013, 2(1): 44-52.
[11] LV S, LIU W, ZHOU Y, et al.Hyperuricemia and severity of coronary artery disease: An observational study in adults 35 years of age and younger with acute coronary syndrome [J]. Cardiol J, 2019, 26(3): 275-282.
[12] KOBAYASHI Y, OMOTE K, NAGAI T, et al.Prognostic value of serum uric acid in hospitalized heart failure patients with preserved ejection fraction(from the Japanese Nationwide Multicenter Registry)[J]. Am J Cardiol, 2020, 125(5): 772-776.

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备注/Memo

备注/Memo:
基金项目:福建省自然科学基金资助项目(2021J011418)
通信作者:佘火标,Email:673637902@qq.com
更新日期/Last Update: 2024-06-15