[1]杨丽英,杨直,杜薇,等.子宫内膜癌PPP2R5A及c-Myc表达与预后的临床关系[J].福建医药杂志,2023,45(05):1-4.
　YANG Liying,YANG Zhi,DU Wei,et al.Expression of PPP2R5A and c-Myc in endometrial cancer and clinical relationship with prognosis[J].FUJIAN MEDICAL JOURNAL,2023,45(05):1-4.
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子宫内膜癌PPP2R5A及c-Myc表达与预后的临床关系()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期数:
2023年05期
页码:
1-4
栏目:
临床研究
出版日期:
2023-10-15

文章信息/Info

Title:
Expression of PPP2R5A and c-Myc in endometrial cancer and clinical relationship with prognosis
文章编号:
1002-2600(2023)05-0001-04
作者:
杨丽英; 杨直; 杜薇; 庄良武1; 高爱明; 程世越
福建中医药大学附属人民医院病理科(福州 350004)
Author(s):
YANG Liying;  YANG Zhi;  DU Wei;  ZHUANG Liangwu;  GAO Aiming;  CHENG Shiyue
Department of Pathology, People's Hospital affiliated to the Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian350004, China
关键词:
子宫内膜癌;  PPP2R5A;  c-Myc;  免疫组化
Keywords:
endometrial cancer;  PPP2R5A;  c-Myc;  immunohistochemistry
分类号:
R737.33
文献标志码:
B
摘要:
目的 探讨PPP2R5A与c-Myc在子宫内膜癌(EC)中的表达,确定两者表达强度及其与患者预后的临床关系。方法 运用免疫组织化学法检Ⅰ型和Ⅱ型子宫内膜癌、子宫内膜不典型增生及正常增生期各12例中子宫内膜组织PPP2R5A与C-myc的表达,分析PPP2R5A、c-Myc蛋白的表达强度与子宫内膜癌临床指标的关系及对子宫内膜癌预后的影响。结果 PPP2R5A在Ⅱ型子宫内膜癌表达强度较其他3组高,差异有统计学意义(P<0.05); Ⅰ型及不典型增生表达强度较正常增生期子宫内膜组织中表达稍强,差异无统计学意义(P>0.05); c-Myc在Ⅱ型EC表达强度较其他3组强高,与正常增生组和不典型增生组相比,差异有统计学意义(P<0.05),与Ⅰ型EC相比,差异无统计学意义(P>0.05); Ⅰ型EC较正常增生组、不典型增生组表达高,差异有统计学意义(P<0.05); PPP2R5A及c-Myc在Ⅰ型和Ⅱ型子宫内膜癌中的表达比较,差异无统计学意义(P>0.05); 子宫内膜癌组织中,PPP2R5A表达与年龄、FIGO分期、淋巴脉管间隙受侵、淋巴结转移情况比较,差异无统计学意义(P>0.05),与组织学分级比较,差异有统计学意义(P<0.05); c-Myc的表达与年龄、FIGO分期比较,差异无统计学意义(P>0.05),与组织学分级、淋巴脉管间隙受侵、淋巴结转移情况比较,差异有统计学意义(P<0.05)。结论 PPP2R5A高表达和c-Myc高表达是影响子宫内膜癌临床进展和预后的独立因素,PPP2R5A对子宫内膜癌特别是Ⅱ型EC的预后和发展过程有一定的提示意义,c-Myc在肿瘤细胞的发生发展过程中发挥着重要作用,通过检测PPP2R5A和c-Myc的表达能够更加有效地评估子宫内膜癌患者的预后。
Abstract:
Objective To investigate the expression of PPP2R5A and c-Myc in endometrial cancer(EC), and to identify the relationship between the expression of PPP2R5A and c-myc and prognosis.Methods The expression of PPP2R5A and c-myc in 12 cases of type I and 12 cases of type Ⅱ endometrial cancer, 12 cases of atypical hyperplasia of endometrium and 12 cases of normal endometrium were detected by immunohistochemistry, the relationship between the expression of PPP2R5A and c-Myc protein and the clinicopathological parameters of endometrial cancer was analyzed.Results The expression of PPP2R5A in type Ⅱ EC was stronger than that in the other three groups, and the expression of PPP2R5A in type I and atypical hyperplasia was stronger than that in normal endometrium, but there was no statistical significance; The expression of c-Myc in type Ⅱ EC was stronger than that in the other three groups, and had statistical significance compared with normal and atypical hyperplasia groups, but had no statistical significance compared with type I EC; The expression of type I EC was significantly higher than that of normal and atypical hyperplasia groups; There was no significant difference in the expression of PPP2R5A and c-Myc between Type I and Type Ⅱ endometrial cancer; The expression of PPP2R5A was not correlated with age, Figo stage, lymphatic space invasion and lymph node metastasis, there was significant correlation with histological grade; The expression of c-Myc was not correlated with age and FIGO stage, there were significant differences with histological grade, lymphatic vessel space invasion and lymph node metastasis.Conclusion The high expression of PPP2R5A and c-Myc is an independent factor affecting the clinical progression and prognosis of endometrial cancer.PPP2R5A may have some implications for the prognosis and development of endometrial cancer, especially type Ⅱ EC, c-Myc also plays an important role in the development of tumor cells,and the detection of the expression of PPP2R5A and c-Myc can more effectively evaluate the prognosis of endometrial cancer patients.

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备注/Memo

备注/Memo:
基金项目:福建省教育厅中青年教师教育科研项目(科技类)(JAT190256)
1 福建中医药大学附属人民医院妇科
更新日期/Last Update: 2023-10-15