[1]林建光,许天文.白蛋白紫杉醇与多西他赛一线治疗老年晚期肺鳞癌的疗效比较[J].福建医药杂志,2021,43(01):51-54.
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白蛋白紫杉醇与多西他赛一线治疗老年晚期肺鳞癌的疗效比较()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期数:
2021年01期
页码:
51-54
栏目:
临床研究
出版日期:
2021-02-10

文章信息/Info

文章编号:
1002-2600(2021)01-0051-03
作者:
林建光许天文1
福建医科大学附属第二医院肿瘤内科(泉州 362000)
关键词:
老年 晚期肺癌 鳞癌 白蛋白紫杉醇 多西他赛
分类号:
R734.2
文献标志码:
B
摘要:
目的 观察比较白蛋白紫杉醇与多西他赛单药一线治疗老年晚期肺鳞癌患者的疗效及不良反应。方法 回顾性分析我院收治的120例老年晚期肺鳞癌患者的临床资料,其中白蛋白紫杉醇组60例、多西他赛组60例,比较两者的疗效及不良反应。结果 白蛋白紫杉醇组与多西他赛组的无进展生存期(PFS)、总生存期(OS)、缓解率(RR)、疾病控制率(DCR)分别为5.2个月和3.3个月,12.4个月和9.0个月,35.0%和21.7%,70.0%和55.0%。白蛋白紫杉醇组的PFS、OS优于多西他赛组,差异有统计学意义(P<0.05),而两组RR、DCR差异无统计学意义(P>0.05)。白蛋白紫杉醇组失眠、血糖升高不良反应发生率低于多西他赛组,差异有统计学意义(P<0.05)。结论 单药白蛋白紫杉醇一线治疗老年晚期肺鳞癌的疗效优于单药多西他赛,且不良反应发生率低,值得推荐。

参考文献/References:

[1] Toh C K, Ong W S, Lim W T, et al.A decade of never-smokers among lung cancer patients-increasing trend and improved survival[J]. Clin Lung Cancer,2018,19(5):e539-e550.
[2] Socinski M A, Obasaju C, Gandara D, et al.Current and emergent therapy options for advanced squamous cell lung cancer[J]. J Thorac Oncol,2018,13(2):165-183.
[3] Sacco P C, Maione P, Palazzolo G, et al.Treatment of advanced non-small cell lung cancer in the elderly[J]. Expert Rev Respir Med,2018,12(9):783-792.
[4] Choi J H, Choi J, Chung S M, et al.The clinical efficacy and safety of four-weekly docetaxel as first-line therapy in elderly lung cancer patients with squamous cell carcinoma[J]. Tuberc Respir Dis(Seoul),2018,81(3):219-225.
[5] Yardley D A.nab-Paclitaxel mechanisms of action and delivery[J]. J Control Release,2013,170(3):365-372.
[6] Socinski M A, Bondarenko I, Karaseva N A, et al.Weekly nab-paclitaxel in combination with carboplatin versus solvent-based paclitaxel plus carboplatin as first-line therapy in patients with advanced non-small-cell lung cancer: final results of a phase Ⅲ trial[J]. J Clin Oncol,2012,30(17):2055-2062.
[7] Gridelli C, Chen T, Ko A, et al.nab-Paclitaxel/carboplatin in elderly patients with advanced squamous non-small cell lung cancer: a retrospective analysis of a Phase Ⅲ trial[J]. Drug Des Devel Ther,2018,12:1445-1451.
[8] Quoix E, Zalcman G, Oster J P, et al.Carboplatin and weekly paclitaxel doublet chemotherapy compared with monotherapy in elderly patients with advanced non-small-cell lung cancer: IFCT-0501 randomised, phase 3 trial[J]. Lancet,2011,378(9796):1079-1088.
[9] Sederholm C, Hillerdal G, Lamberg K, et al.Phase Ⅲ trial of gemcitabine plus carboplatin versus single-agent gemcitabine in the treatment of locally advanced or metastatic non-small-cell lung cancer: the Swedish Lung Cancer Study Group[J]. J Clin Oncol,2005,23(33):8380-8388.
[10] Mok T, Wu Y L, Kudaba I, et al.Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer(KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial[J]. Lancet,2019,393(10183):1819-1830.
[11] Paz-Ares L, Luft A, Vicente D, et al.Pembrolizumab plus chemotherapy for squamous non-small-cell lung cancer[J]. N Engl J Med,2018,379(21):2040-2051.

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更新日期/Last Update: 2021-02-10