[1]陈国平 陈剑明.多项肿瘤标记物在胃癌诊断中的筛选及应用价值[J].福建医药杂志,2019,41(02):4-7.
　CHEN Guoping,CHEN Jianming..Value of screening and application of multiple combined tumor markers in the diagnosis of gastric cancer[J].FUJIAN MEDICAL JOURNAL,2019,41(02):4-7.
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多项肿瘤标记物在胃癌诊断中的筛选及应用价值()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
41
期数:
2019年02期
页码:
4-7
栏目:
临床研究
出版日期:
2019-01-30

文章信息/Info

Title:
Value of screening and application of multiple combined tumor markers in the diagnosis of gastric cancer
文章编号:
1002-2600(2019)02-0004-04
作者:
陈国平 陈剑明
厦门大学附属福州第二医院普通外科(福州 350007)
Author(s):
CHEN Guoping;  CHEN Jianming.
Department of General surgery,the Affiliated Fuzhou Municipal Second Hospital,Xiamen University,Fuzhou, Fujian 350007, China
关键词:
胃癌;  肿瘤标记物;  微阵列酶联免疫法;  联合检测
Keywords:
gastric cancer;  tumor markers;  microarray enzyme-linked immunosorbent assay;  combined detection
分类号:
R735
文献标志码:
B
摘要:
目的 探讨多项肿瘤标记物在胃癌诊断中的筛选及应用价值。方法 通过 Array- ELISA检测胃癌患者(胃癌组)、健康体检者(对照组)血清中在癌胚抗原(CEA)、糖类抗原199 (CA199)、糖类抗原242(CA242)、糖类抗原724(CA724)、糖类抗原50(CA50)、甲胎蛋白(AFP)、 糖类抗原125(CA125)、糖类抗原153(CA153)、人绒毛膜促性腺激素(HCG)、糖分解烯醇酶(NSE) 这10种肿瘤标志物的水平,并考察这些单项肿瘤标志物与多项联合检测胃癌的敏感度、特异度 和准确度。结果 胃癌组除HCG之外,其余9种肿瘤标志物水平较对照组均明显升高 (P<0.05)。单项检测灵敏度、特异度及准确度最高的前三位肿瘤标记物,共计4种, 分别为CA724、CA199、CEA及AFP。CA724+CA199+CEA+AFP四联联合检测的灵敏度、特异度及准 确度最高,分别为96.50%、97.94%、91.11%。结论 采用Array-ELISA联合检测CA724、CA199、 CEA及AFP将大大提升胃癌的早期诊断水平。
Abstract:
Objective To explore the value of screening and detection of single and multiple combined tumor markers in the diagnosis of gastric cancer.Methods Array-ELISA was used to detect the level of the substance of ten tumor markers,including carcinoembryonic antigen(CEA), carbohydrate antigen 199(CA199), carbohydrate antigen 242(CA242), carbohydrate antigen 724(CA724), carbohydrate antigen 50(CA50), alpha-fetoprotein(AFP), carbohydrate antigen 125(CA125), carbohydrate antigen 153(CA153), human chorionic gonadotropin(HCG), and saccharolytic enolase(NSE)in the serum of patients with gastric cancer and healthy subjects.The sensitivity, specificity and accuracy of these single tumor markers combined with multiple detection of gastric cancer were compared.Results In addition to HCG, the levels of the other nine tumor markers in the gastric cancer group were significantly higher than those in the control group (P<0.05).The top three single tumor markers with the highest sensitivity, specificity and accuracy were CA724,CA199,CEA and AFP.The sensitivity, specificity and accuracy of CA724+CA199+CEA+AFP was highest, which were 96.50%, 97.94%,91.11% respectively.Conclusion The combination of Array-ELISA for detection of CA724, CA199, CEA and AFP will improve the early diagnosis of gastric cancer greatly.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:2017年福州市卫生计生科技计划中青年科研项目(2017-S-wq28)
更新日期/Last Update: 2019-01-30