[1]侯志婷,林毅胜,丁培燕,等.泉州地区献血人群ABO、Rh血型分布特点分析[J].福建医药杂志,2024,46(06):14-17.[doi:10.20148/j.fmj.2024.06.004]
　HOU Zhiting,LIN Yisheng,DING Peiyan,et al.Distribution of ABO and Rh blood group among blood donors in Quanzhou[J].FUJIAN MEDICAL JOURNAL,2024,46(06):14-17.[doi:10.20148/j.fmj.2024.06.004]
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泉州地区献血人群ABO、Rh血型分布特点分析()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期数:
2024年06期
页码:
14-17
栏目:
临床研究
出版日期:
2024-11-15

文章信息/Info

Title:
Distribution of ABO and Rh blood group among blood donors in Quanzhou
文章编号:
1002-2600(2024)06-0014-04
作者:
侯志婷; 林毅胜; 丁培燕; 陈吓燕; 黄小静; 章永明
福建省泉州市中心血站,泉州 362000
Author(s):
HOU Zhiting;  LIN Yisheng;  DING Peiyan;  CHEN Xiayan;  HUANG Xiaojing;  ZHANG Yongming
Quanzhou Central Blood Station, Quanzhou, Fujian 362000, China
关键词:
ABO血型;  Rh血型;  血型分布;  基因频率;  泉州
Keywords:
ABO blood group;  Rh blood group;  blood group distribution;  allelic frequency;  Quanzhou
分类号:
R457.1+1
DOI:
10.20148/j.fmj.2024.06.004
文献标志码:
B
摘要:
目的 探讨泉州地区献血人群ABO和Rh血型分布特点,丰富稀有表型资料库,以期指导采供血计划和无偿献血者招募策略的制订,保障泉州地区的临床用血。方法 收集2018—2022年泉州市190 195名献血者数据,分析其ABO和RhD血型分布特点,进行ABO血型Hardy-Weinberg吻合度检验,并对2022年8月至2024年4月本站RhD阴性标本进行RhC、c、E、e抗原分型检测,建立稀有表型资料库。结果 泉州地区献血人群ABO表现型O>A>B>AB,基因频率r>p>q,期望值与观察值差异有统计学意义,不符合Hardy-Weinberg遗传规律。汉族RhD阴性献血者占比0.44%,271名RhD阴性献血者中,共检出6种表现型:ccdee>Ccdee>CCdee>ccdEe>CcdEe>--dee; 未检出CcdEE、ccdEE、CCdEE、CCdEe,2例未检出C(c)抗原,RhC、c、E、e抗原频率由高到低均为e>c>C>E。结论 血型遗传规律不能真实反映献血人群的血型分布,根据研究所得的献血人群ABO和Rh血型分布特点可用来指导制订采供血计划和精准的无偿献血者招募策略,保障本地区的血液供应。
Abstract:
Objective Determining the distribution of ABO and Rh phenotypes among blood donors in Quanzhou and enriching the rare phenotype database will allow us to ensure better management of blood stocks and good recruitment strategies for supplying Quanzhou with blood products. Methods The data of 190 195 blood donors in Quanzhou from 2018 to 2022 were collected to analyze the ABO and RhD blood group distribution characteristics, and the ABO blood group were performed Hardy-Weinberg equilibrium test; RhC, c, E and e antigen typing detections were performed on RhD-negative individuals from August 2022 to April 2024 to establish a rare phenotype database. Results O>A>B>AB and r>p>q in our blood donors were noticed. The differences between expected frequency and observed frequency were statistically significant which didnt accord with Hardy-Weinberg equilibrium rules. The frequency of RhD-Negative in Han nationality blood donors was 0.44%. We found 6 phenotypes among 271 RhD negative blood donors: ccdee>Ccdee>CCdee>ccdEe>CcdEe>--dee; no CcdEE, ccdEE, CCdEE, CCdEe were detected, and no C(c)antigen was detected in 2 cases. The frequency of RhC, c, E, e antigens was e>c>C>E respectively. Conclusion The genetic rules of blood group can not truly reflect the blood group distribution of blood donors. The ABO and Rh blood group distribution characteristics of blood donors obtained in this study can be used to guide the development of blood procurement plans and accurate recruitment strategies for blood donors, so as to ensure the blood supply in our region.

参考文献/References:

[1] 广东省医院协会. T/GDPHA,Rh血型抗原检测应用标准[S/OL]. (2024-03-14)[2024-05-01]. https://bbs.biaozhuns.com/thread-458779-1-1.html
[2] 赵桐茂.人类血型遗传学[M]. 北京:科学出版社,1987:102-106,218,226-232.
[3] SUN Y, WANG L, NIU J, et al. Distribution characteristics of ABO blood groups in China[J]. Heliyon, 2022,8(9):105-114.
[4] 唐舞,池泉,葛红卫.福州地区无偿献者ABO、Rh血型分布调查[J]. 福建医药杂志, 2007,29(4):127-128.
[5] 曹丹,昝小玲,朱海峰,等.济南市无偿献血人群ABO血型及与Rh血型分布研究[J]. 华南预防医学, 2021,47(4):416-420.
[6] 闫芳,张磊,张烨,等.北京地区RhD阴性献血人群Rh血型研究[J]. 中国输血杂志, 2017,30(1):56-57.
[7] 李雄英,孔庆芳,谭庆芬,等.459例RhD阴性献血者ABO、Rh、MN和P血型基因频率的调查[J]. 临床输血与检验, 2017,19(5):494-497.
[8] 李敏,张麦利,赵宝娟,等.RhD阴性献血者Rh血型及不规则抗体调查分析[J]. 检验医学与临床, 2023,20(14):2124-2126.
[9] 周赟,代静,蔡兰,等.无偿献血人群RhD阴性血型分布研究[J]. 临床血液学杂志, 2023,36(8):545-547.
[10] 张爱,林洪铿,何觅,等.福州地区献血人群Rh血型分布特征的调查分析[J]. 福建医药杂志, 2020,42(2):125-127.

备注/Memo

备注/Memo:
基金项目:泉州市科技计划项目(2022NS038)
通信作者:林毅胜,Email: 278168007@qq.com
更新日期/Last Update: 2024-11-15