[1]曾艳芬,曹鹏驹,窦敏.纤维蛋白（原）降解产物/D-二聚体比值的临床应用探讨[J].福建医药杂志,2023,45(04):16-19.
　ZENG Yanfen,CAO Pengju,DOU Min.Exploration of the clinical application of FDP/DD ratio[J].FUJIAN MEDICAL JOURNAL,2023,45(04):16-19.
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纤维蛋白（原）降解产物/D-二聚体比值的临床应用探讨()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期数:
2023年04期
页码:
16-19
栏目:
临床研究
出版日期:
2023-08-15

文章信息/Info

Title:
Exploration of the clinical application of FDP/DD ratio
文章编号:
1002-2600(2023)04-0016-04
作者:
曾艳芬; 曹鹏驹1; 窦敏1; 2
福建省立医院 福建省临床检验中心(福州 350001)
Author(s):
ZENG Yanfen;  CAO Pengju;  DOU Min
Fujian Provincial Center for Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, Fujian 350001, China
关键词:
D-二聚体;  FDP;  FDP/DD比值;  临床应用
Keywords:
D-dimer;  FDP;  FDP/DD ratio;  clinical application
分类号:
R34
文献标志码:
B
摘要:
目的 探讨纤维蛋白(原)降解产物(FDP)/纤维蛋白降解产物D-二聚体(DD)比值在不同检测系统的差异、对DIC高凝期的鉴别效能及对DD检测结果的干扰识别能力。方法 非DIC患者90例,同时在CS5100和STA-R-Evolution检测DD、FDP,计算FDP/DD比值; 回顾分析20例DIC高凝期、20例DIC纤溶期,计算FDP/DD比值; 另收集FDP/DD比值<1.7和FDP/DD比值2～3的标本各10例,分别检测原倍和1:8稀释的DD结果,计算稀释前后FDP/DD比值。结果 90例非DIC患者两台仪器DD在中值组和高值组差异有统计学意义(P<0.05), FDP3组差异无统计学意义(P>0.05); FDP/DD3组差异均有统计学意义(P<0.05)。DIC高凝期组与非DIC组比较,差异有统计学意义(P<0.01); DIC高凝期组与纤溶组比较差异有统计学意义(P<0.01)。正常组1:8稀释后中的DD、FDP/DD比值与原倍差异无统计学意义(P>0.05); 干扰组1:8稀释后DD、FDP/DD比值与原倍比较,差异有统计学意义(P<0.05)。结论 FDP/DD比值在两种检测系统的差异有统计学意义; 能为临床DIC早期高凝阶段的诊断提供帮助; 能有效识别DD检测干扰。
Abstract:
Objective To explore the difference of FDP/DD ratio in different detection systems, the discriminating efficiency of highcoagulation stage of DIC and the ability of interference identification of DD detection results. Methods A total of 90 inpatients with non-DIC were collected, at the same time, DD and FDP were detected by CS5100 and STA-R-E-vdution, and the FDP/DD ratio was calculated. According to the test results of TAT, PIC, Fib, Plt and thromboelastography, 20 cases of DIC hypercoagulable phase and 20 cases of DIC fibrinolytic phase were selected to calculate the FDP/DD ratio. In addition, 10 cases with FDP/DD ratio <1.7 and 10 inpatients with FDP/DD ratio 2-3 were collected. The DD results of primary dilution and 1:8 dilution were detected respectively, and the FDP/DD ratio before and after dilution was calculated. Results In 90 non-DIC patients, there was a significant difference in DD between the median group and the high group(P<0.05), but there was no significant difference in FDP among the three groups(P>0.05). There were significant differences in FDP/DD among the three groups(P<0.05). There was significant difference between DIC hypercoagulable group and non-DIC group(P<0.01). There was significant difference between the DIC high coagulation stage group and fibrinolysis group(P<0.01). There was no significant difference in DD and FDP/DD ratio between 1:8 dilution and original fold in normal group(P>0.05). There were significant differences in DD and FDP/DD ratio between the interference group and the original ratio after 1:8 dilution(P<0.05). Conclusion FDP/DD ratio is significantly different between the two detection systems, which can provide meaningful help for the diagnosis of early hypercoagulablestage of DIC and effectively identify the interference of DD detection.

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备注/Memo

备注/Memo:
1 福建省立医院检验科; 2 通信作者,Email: 13675036397@126.com
更新日期/Last Update: 2023-08-15