[1]郑润君,陈埼,詹庆芳,等.海马损伤对奥氮平治疗首发精神分裂症效果的影响[J].福建医药杂志,2022,44(02):11-13.
　ZHENG Runjun,CHEN Qi,ZHAN Qingfang,et al.Effect of hippocampal injury on olanzapine in the treatment of first-episode schizophrenia[J].FUJIAN MEDICAL JOURNAL,2022,44(02):11-13.
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海马损伤对奥氮平治疗首发精神分裂症效果的影响()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期数:
2022年02期
页码:
11-13
栏目:
临床研究
出版日期:
2022-04-15

文章信息/Info

Title:
Effect of hippocampal injury on olanzapine in the treatment of first-episode schizophrenia
文章编号:
1002-2600(2022)02-0011-03
作者:
郑润君; 陈埼; 詹庆芳; 黄少雅; 翁赛峥
福建省福州神经精神病防治院(福州 350008)
Author(s):
ZHENG Runjun;  CHEN Qi;  ZHAN Qingfang;  HUANG Shaoya;  WENG Saizheng
Fuzhou Neuropsychiatric Hospital of Fujian Province, Fuzhou, Fujian 350008, China
关键词:
海马损伤;  首发精神分裂症;  海马磁共振质子波谱分析
Keywords:
hippocampal injury;  first-episode schizophrenia;  proton magnetic resonance spectroscopy of hippocampal
分类号:
R749.3
文献标志码:
B
摘要:
目的 探讨海马损伤对奥氮平治疗首发精神分裂症患者效果的影响。方法 对首发精神分裂症患者进行海马磁共振质子波谱分析,并据此分为海马损伤组及海马正常组各15例,两组患者均采用奥氮平治疗,分别在治疗前及治疗6个月后选择使用阳性和阴性症状量表(PANSS)对患者精神分裂程度进行分析,内容涉及阴性症状、阳性症状、一般精神病理和总分。结果 与海马正常组比较,海马损伤组奥氮平治疗前后PANSS评分中各项评分差值降低得更小,差异均有统计学意义(P<0.05)。结论 有海马损伤的首发精神分裂症患者,奥氮平治疗的效果更差。
Abstract:
Objective To investigate the effect of hippocampal injury on olanzapine in the treatment of first-episode schizophrenia.Methods Proton magnetic resonance spectroscopy was performed in patients with first-episode schizophrenia.According to this, 30 cases were divided into hippocapus injury group and normal hippocampus group respectively, there were 15 cases in each group. Both groups were treated with olanzapine, positive and negative symptom scales(PANSS)were used to analyze the degree of schizophrenia before and after treatment for 6 months. The content covered negative symptoms, positive symptoms, psychopathology and total scores.Results Compared with the normal hippocampal group, the differences of PANSS scores in the hippocampal injury group were smaller before and after olanzapine treatment, the differences were statistically significant(P<0.05).Conclusion Olanzapine is less effective in first-episode schizophrenia with hippocampal damage.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:福州市科技计划项目(2019-SZ-62)
更新日期/Last Update: 2022-04-15