[1]周雨燕,林,帆,等.Apelin-13对高糖诱导的功能障碍血管内皮的作用探讨[J].福建医药杂志,2021,43(04):136-137.
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Apelin-13对高糖诱导的功能障碍血管内皮的作用探讨()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期数:
2021年04期
页码:
136-137
栏目:
基础研究
出版日期:
2021-08-15

文章信息/Info

文章编号:
1002-2600(2021)04-0136-03
作者:
周雨燕叶志强朱鹏立1
福建医科大学省立临床医学院 福建省立医院老年科(福州 350101)
关键词:
Apelin-13高糖凋亡增殖人脐静脉内皮细胞
分类号:
R587.1
文献标志码:
B
摘要:
目的 探讨Apelin-13对高糖环境下人脐静脉内皮细胞(HUVECs)是否具有保护作用。 方法 实验Ⅰ,CCK-8法检测48 h后HUVECs在不同糖浓度环境下的增殖活性。实验Ⅱ,实验分组为空白对照组、模型组、实验组,分别培养16、24、48 h,CCK-8检测细胞增殖活性。实验Ⅲ,实验分组为空白对照组、模型组、实验组,48 h后流式细胞术检测细胞凋亡率。 结果 选择33 mmol/L作为高糖损伤模型的糖浓度。Apelin可改善高糖环境下的HUVECs增殖活性,且48 h作用时间、10-8 mol/L Apelin的条件下,Apelin的增益效果更明显。Apelin可抑制高糖环境下的HUVECs的早期凋亡。 结论 Apelin/APJ轴对高糖诱导的血管内皮功能障碍起保护作用。

参考文献/References:

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更新日期/Last Update: 2021-08-15