[1]林 萍,郑淑霞,官瑞婷,等.伴异常染色体核型的初诊急性髓系白血病临床及实验室特征分析[J].福建医药杂志,2021,43(02):21-24.
　LIN Ping,ZHENG Shuxia,GUAN Ruiting,et al.Clinical and laboratory characteristics and prognostic factors of initial diagnosed acute myeloid leukemia with abnormal karyotype[J].FUJIAN MEDICAL JOURNAL,2021,43(02):21-24.
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伴异常染色体核型的初诊急性髓系白血病临床及实验室特征分析()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期数:
2021年02期
页码:
21-24
栏目:
临床研究
出版日期:
2021-04-15

文章信息/Info

Title:
Clinical and laboratory characteristics and prognostic factors of initial diagnosed acute myeloid leukemia with abnormal karyotype
文章编号:
1002-2600(2021)02-0021-04
作者:
林 萍; 郑淑霞; 官瑞婷; 张雅兰; 杜秀环; 叶小翠; 谢若腾1
福建医科大学附属第二医院检验科(泉州 362000)
Author(s):
LIN Ping;  ZHENG Shuxia;  GUAN Ruiting;  ZHANG Yalan;  DU Xiuhuan;  YE Xiaocui;  XIE Ruoteng
Department of Medical Laboratory, the Second Affiliated Hospital of Fujian Medical University,Quanzhou,Fujian 362000,China
关键词:
染色体;  染色体核型异常;  急性髓系白血病; AML;  临床特征;  病态造血
Keywords:
chromosome;  chromosome karyotype abnormality;  acute myeloid leukemia; AML;  clinical features;  morbid hematopoiesis
分类号:
R733.71
文献标志码:
B
摘要:
目的 探讨伴异常染色体核型的初诊急性髓系白血病(acute myeloid leukemia,AML)患者的临床、实验室特征。方法 收集我院收治的伴异常染色体核型的初诊AML患者资料,分析其临床及实验室资料。结果 除M2b外14例患者骨髓合并病态造血,FAB分型中M2a13例、M51例,染色体核型中复杂核型10例、单体核型2例、染色体易位2例。71例异常染色体核型表现为染色体易位42例(其中M2b6例,M321例,M4EO4例)、单体核型14例、复杂核型15例。结论 伴异常染色体核型的初诊AML以染色体易位为主,但除M2b、M3、M4EO外,3种染色体核型异常(染色体易位、单体核型、复杂核型)无明显差异。合并病态造血的AML多见于复杂核型且以M2a为主。
Abstract:
Objective To investigate the clinical and laboratory features and prognosis of initial diagnosed acute myeloid leukemia(AML)patients with abnormal karyotype.Methods Clinical laboratory data and prognostic factors of initial diagnosed AML patients with abnormal karyotype admitted to our hospital were retrospectively analyzed.Results In addition to M2b, 14 patients had morbid hematopoiesis in bone marrow,according to FAB classification, 23 cases were M2a and 1 case was M5.Among the 71 cases of abnormal karyotypes, there were mainly 42 cases of chromosomal translocations(there were 6 cases of M2b, 21 cases of M3 and 4 cases of M4EO), 14 cases of monomer karyotypes and 15 cases of complex karyotypes. Conclusion The newly diagnosed AML patients with abnormal karyotype are mainly chromosomal translocation,except M2b,M3,and M4EO, there is no significant difference among the three karyotypes(chromosomal translocation,monomer karyotype,and complex karyotype).AML with morbid hematopoiesis is more common in patients with complex karyotype and M2a is the main type.

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备注/Memo

备注/Memo:
1 通信作者,Email: 22749148@qq.com
更新日期/Last Update: 2021-04-15