[1]郭慈仁,陈桂林,江信燕,等.P53、ER、PR在Ⅰ期子宫内膜癌中的表达及其与临床病理特征的相关性分析[J].福建医药杂志,2021,43(01):17-20.
　GUO Ciren,CHEN Guilin,JIANG Xinyan,et al.Expression of P53, estrogen receptor and progesterone receptor in stageⅠendometrial carcinoma and their relationship with clinicopathological characteristics[J].FUJIAN MEDICAL JOURNAL,2021,43(01):17-20.
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P53、ER、PR在Ⅰ期子宫内膜癌中的表达及其与临床病理特征的相关性分析()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期数:
2021年01期
页码:
17-20
栏目:
临床研究
出版日期:
2021-02-10

文章信息/Info

Title:
Expression of P53, estrogen receptor and progesterone receptor in stageⅠendometrial carcinoma and their relationship with clinicopathological characteristics
文章编号:
1002-2600(2021)01-0017-04
作者:
郭慈仁; 陈桂林; 江信燕; 石怀景; 林洁1
福建省肿瘤医院 福建医科大学附属肿瘤医院妇科(福州 350014)
Author(s):
GUO Ciren;  CHEN Guilin;  JIANG Xinyan;  SHI Huaijing;  LIN Jie.
Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Department of Tumor Gynecology, Fuzhou,Fujian 350014, China
关键词:
P53;  雌激素受体;  孕激素受体;  子宫内膜癌
Keywords:
P53;  estrogen rcceptor;  progesterone receptor;  endometrial carcinoma
分类号:
R737.33
文献标志码:
B
摘要:
目的 观察Ⅰ期子宫内膜癌中P53、雌激素受体(ER)、孕激素受体(PR)的表达情况,并探讨其与临床病理特征的关系。方法 应用免疫组化S-P法检测2015年5月至2020年7月我院收治的188例临床诊断为Ⅰ期的子宫内膜癌患者术后癌组织标本中P53、ER、PR的表达情况,应用统计学方法分析其表达与临床病理特征间的关系。结果 1)P53、ER、PR在Ⅰ期子宫内膜癌中的阳性表达率分别为60.6%、90.4%和85.6%; 2)P53的表达与组织学类型、淋巴结转移有关(均P<0.05),而与年龄、组织学分级、脉管癌栓及深肌层浸润无关(均P>0.05); ER、PR的表达与组织学类型、组织学分级有关(均P<0.05),而与年龄、淋巴结转移、脉管癌栓及深肌层浸润无关(均P>0.05)。结论 联合检测P53、ER、PR有助于了解早期子宫内膜癌的生物学行为,对术后内分泌治疗及预后评估有一定的参考价值。
Abstract:
Objective To observe the expression of P53, estrogen receptor(ER)and progesterone receptor(PR)in stage Ⅰ endometrial carcinoma and to explore their relationship with clinicopathological characteristics.Methods S-P immunohistochemical technique was used to detect the expression of P53, ER and PR in the postoperative cancer tissues of 188 patients with stage Ⅰ endometrial carcinoma who were clinically diagnosed in our hospital form May 2015 to July 2020, the relationship between its expression and clinicopathological features was statistically analyzed at the same time.Results The positive expression rates of P53, ER and PR in stage Ⅰ endometrial carcinoma were 60.6%,90.4% and 85.6%, respectively.The expression of P53 was significant association with histological type and lymph nodes metastasis(P<0.05), but not with patient age, histological grade, lymphatic vascular space infiltration and deep muscle invasion(P>0.05).The expression of ER and PR was significant association with histological type and histological grade(P<0.05), but not with patient age, lymph nodes metastasis, lymphatic vascular space infiltration and deep muscle invasion(P>0.05).Conclusion The results of our experiment suggest that combined detection of P53, ER and PR is helpful to understand the biological behavior of early endometrial carcinoma and has certain reference value for postoperative prognosis evaluation.

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更新日期/Last Update: 2021-02-10