[1]黄 婷 赵如意 徐文林 连媛媛 孙伟明 陈敬华.基于近红外光谱技术快速检测中药制剂中马兜铃酸含量的 实验研究[J].福建医药杂志,2019,41(02):122-126.
 HUANG Ting,ZHAO Ruyi,XU Wenlin,et al.Rapid detection of aristolochic acid concentrations in Chinese medicines preparations based on the near infrared spectroscopy[J].FUJIAN MEDICAL JOURNAL,2019,41(02):122-126.
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基于近红外光谱技术快速检测中药制剂中马兜铃酸含量的 实验研究()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
41
期数:
2019年02期
页码:
122-126
栏目:
基础研究
出版日期:
2019-01-30

文章信息/Info

Title:
Rapid detection of aristolochic acid concentrations in Chinese medicines preparations based on the near infrared spectroscopy
文章编号:
1002-2600(2019)02-0122-05
作者:
黄 婷 赵如意 徐文林 连媛媛 孙伟明1 陈敬华
福建医科大学药学院(福州 350108)
Author(s):
HUANG TingZHAO Ruyi XU Wenlin LIAN Yuanyuan SUN Weiming CHEN Jinghua.
The School of Pharmacy, Fujian Medical University, Fuzhou,Fujian 350108, China
关键词:
近红外光谱 马兜铃酸 主成分分析法 偏最小二乘法
Keywords:
near infrared spectroscopy aristolochic acid principle component analysis partial least squares
分类号:
R917
文献标志码:
B
摘要:
目的 研究近红外光谱(NIRs)技术结合化学计量法构建定性、定量分析模型对中药制 剂中的马兜铃酸进行检测。方法 应用NIRs结合主成分分析法(PCA)对关木通、川木通以及含有 不同浓度的马兜铃酸I的淀粉样本进行定性分析。采用NIRs结合偏最小二乘法(PLS)对仿中药制 剂样品中马兜铃酸I的含量进行定量分析,用6种预处理方法对光谱图进行优化,建立仿中药制剂 样品定量分析模型。结果 定性分析模型具有100%判别率,并找到了最优的SG卷积平滑二阶预处 理方法,确立了定量分析模型。结论 NIRs技术可为中药制剂中马兜铃酸含量的检测提供一种准 确、易行、成本低、适用性广的新方法。
Abstract:
Objective To use near infrared spectrum(NIRs)technology to construct the qualitative and quantitative models for detecting aristolochic acid concentrations in traditional Chinese preparations.Methods The NIRs combined with principal component analysis(PCA)was employed to conduct the qualitative analysis and the NIR spectra combined with partial least squares(PLS)was used to quantitatively analyze the concentrations of aristolochic acid in the imitative traditional Chinese preparation samples via employing six pretreatment methods.Results The accuracy rate of the qualitative model was up to 100%, and the Savitzky-Golay second derivative preparing method was identified to be the best one to achieve the quantitative model.Conclusion The NIR spectroscopy can provide an accurate, convenient, low cost, and widely applicable method for the detection of the content of aristolochic acid in the traditional Chinese preparations.

参考文献/References:

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更新日期/Last Update: 2019-01-30