[1]姜聪,王娅,林芝,等.维持性血液透析患者骨质疏松影响因素的Meta分析[J].福建医药杂志,2025,47(01):9-13.[doi:10.20148/j.fmj.2025.01.003]
　JIANG Cong,WANG Ya,LIN Zhi,et al.Meta-analysis of influencing factors of osteoporosis in patients with maintenance hemodialysis[J].FUJIAN MEDICAL JOURNAL,2025,47(01):9-13.[doi:10.20148/j.fmj.2025.01.003]
点击复制

维持性血液透析患者骨质疏松影响因素的Meta分析()
分享到：

《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
47
期数:
2025年01期
页码:
9-13
栏目:
临床研究
出版日期:
2025-01-20

文章信息/Info

Title:
Meta-analysis of influencing factors of osteoporosis in patients with maintenance hemodialysis
文章编号:
1002-2600(2025)01-0009-05
作者:
姜聪1; 王娅1; 林芝1; 穆艳2
1 福建中医药大学护理学院,福州 350122; 2 福建中医药大学教学医院护理部(福州大学附属省立医院护理部),福州 350001
Author(s):
JIANG Cong1;  WANG Ya1;  LIN Zhi1;  MU Yan2
1 College of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122,China; 2 Fujian University of Traditional Chinese Medicine Teaching Hospital(Fuzhou University Affiliated Provincial Hospital), Fuzhou, Fujian 350001,China
关键词:
终末期肾脏病;  维持性血液透析;  影响因素;  骨质疏松;  Meta分析
Keywords:
maintenance hemodialysis;  end-stage renal disease;  influencing factors;  osteoporosis;  meta-analysis
分类号:
R473.5
DOI:
10.20148/j.fmj.2025.01.003
文献标志码:
B
摘要:
目的 对维持性血液透析患者骨质疏松的相关因素进行Meta分析。方法 检索范围包括PubMed、Embase、Web of Science、Cochrane Library、中国知网、维普、万方及中国生物医学文献数据库,检索时间范围为建库至2024年8月。由两名研究人员独立筛选文献、提取数据并进行讨论分析,采用RevMan 5.4软件进行Meta分析。结果 共纳入12篇文献。结果显示,女性(OR=3.47,95%CI:2.47,4.88)、透析时间长(OR=2.84,95%CI:1.71,4.70)、低BMI(OR=2.38,95%CI:1.08,5.25)、高甲状旁腺素(OR=4.30,95%CI:2.20,8.47)、高龄(OR=1.72,95%CI:1.30,2.28)、患糖尿病(OR=2.94,95%CI:1.80,4.81)、碱性磷酸酶高(OR=3.41,95%CI:1.91,6.09)、绝经(OR=7.56,95%CI:2.87,20.36)为骨质疏松发生的危险因素。结论 维持性血液透析患者骨质疏松的影响因素较多,应及早对维持性血液透析患者的骨质状况进行干预,降低其不良结局的发生率。
Abstract:
Objective To explore the factors associated with osteoporosis outcomes in patients with maintenance hemodialysis through meta-analysis. Methods The search was conducted across PubMed, Embase, Web of Science, Cochrane Library, CNKI, VIP, Wanfang, and CBM databases, covering the period from database inception to August 2024. Two independent researchers screened the literature, extracted the data, and resolved discrepancies through discussion and analysis. Meta-analysis was performed using RevMan 5.4 software. Results A total of 12 literatures were included. The results showed that female gender(OR=3.47,95%CI:2.47,4.88), long duration of dialysis(OR=2.84,95%CI:1.71, 4.70), low BMI(OR=2.38,95%CI:1.08,5.25), high parathyroid hormone(OR=4.30,95%CI:2.20,8.47), advanced age(OR=1.72,95%CI:1.30,2.28), having diabetes mellitus(OR=2.94,95%CI:1.80,4.81), high alkaline phosphatase(OR=3.41,95%CI:1.91,6.09), and menopause(OR=7.56,95%CI:2.87,20.36)were the risk factors for osteoporosis development. Conclusion Various factors can affect osteoporosis in patientswith maintenance hemodialysis,and early interventions should be made to reduce the incidence of adverse outcomes in the bone status of maintenance hemodialysis patients.

参考文献/References:

[1] 罗诏耀, 欧阳远朔, 苏航, 等. 维持性血液透析终末期肾病患者丘脑功能连接异常与记忆减退的相关性研究[J]. 西安交通大学学报:医学版,2024,45(2):292-297.
[2] Ullrich B W, Schnake K J, Schenk P, et al. Clinical evaluation of the osteoporotic fracture treatment score(of-score): results of the evaluation of the osteoporotic fracture classification, treatment score and therapy recommendations(eoftt)study[J]. Global Spine J, 2023,13(1 suppl):29-35.
[3] Kashgary A, Attiah F, AlKhateeb N A, et al. Incidence of bone fractures among patients on maintenance hemodialysis[J]. Ren Fail, 2023,45(1):2224456.
[4] 魏雪, 纪云龙, 仇方忻. 维持性血液透析患者发生骨质疏松的危险因素分析[J]. 菏泽医学专科学校学报, 2023,35(2):14-18.
[5] Wang Y, Ma W, Pu J, et al. Interrelationships between sarcopenia, bone turnover markers and low bone mineral density in patients on hemodialysis[J]. Ren Fail, 2023,45(1):2200846.
[6] 吴培清, 郑丽花, 方君, 等. 尿毒症患者并发骨质疏松症的相关影响因素及护理管理策略分析[J]. 山西医药杂志, 2023,52(20):1541-1544.
[7] 王琰, 罗静, 苗金红. 血液净化中心维持性血液透析患者骨质疏松危险因素分析及骨折风险预测[J]. 热带医学杂志, 2022,22(3):373-377.
[8] 沈妍. 维持性血液透析患者骨质疏松症的发生情况及其影响因素[J]. 当代医学, 2022,28(1):16-18.
[9] 梁冰, 王鹏鸽, 王萌萌. 血清IL-34、FGF23及OPG与维持性血液透析患者骨质疏松相关性分析[J]. 实用中西医结合临床, 2022,22(16):83-85.
[10] 薛劲松, 杨书平, 鞠杰, 等. 维持性血液透析患者骨密度情况及发生骨质疏松的影响因素分析[J]. 中外医学研究, 2021,19(21):133-135.
[11] 楼超, 邵鹏. 影响维持性血液透析围绝经期女性患者发生骨质疏松的危险因素分析[J]. 中国妇幼保健, 2021,36(20):4842-4845.
[12] 张向前, 王雪侠. 血清IL-32γ、IL-6水平与维持性血液透析患者骨密度的关系研究[J]. 实验与检验医学, 2021,39(5):1172-1175.
[13] Lu C W, Wang C H, Hsu B G, et al. Serum osteoprotegerin level is negatively associated with bone mineral density in patients undergoing maintenance hemodialysis[J]. Medicina(Kaunas), 2021,57(8).
[14] Hashimoto H, Shikuma S, Mandai S, et al. Calcium-based phosphate binder use is associated with lower risk of osteoporosis in hemodialysis patients[J]. Sci Rep, 2021,11(1):1648.
[15] 张立新. 维持性血液透析患者骨质疏松症发生情况及其影响因素[J]. 医学临床研究, 2018,35(10):2031-2033.
[16] 何海洋, 杨嘉玲, 雷迅. 绝经后女性骨质疏松症患病率及影响因素的Meta分析[J]. 中国全科医学, 2024,27(11):1370-1379.
[17] Ruiz L R, Calvo G J L, Pivonka P, et al. An in silico approach to elucidate the pathways leading to primary osteoporosis: age-related vs. postmenopausal[J]. Biomech Model Mechanobiol, 2024,23(4):1393-1409.
[18] Zhivodernikov I V, Kirichenko T V, Markina Y V, et al. Molecular and cellular mechanisms of osteoporosis[J]. Int J Mol Sci, 2023,24(21):15772.
[19] Neves R, Correa H L, Deus L A, et al. Dynamic not isometric training blunts osteo-renal disease and improves the sclerostin/FGF23/Klotho axis in maintenance hemodialysis patients: a randomized clinical trial[J]. J Appl Physiol(1985), 2021,130(2):508-516.
[20] Qu Y D, Zhu Z H, Li J X, et al. Diabetes and osteoporosis: a two-sample mendelian randomization study[J]. BMC Musculoskelet Disord, 2024,25(1):317.

备注/Memo

备注/Memo:
通信作者:穆 艳,Email:muyan06@126.com
更新日期/Last Update: 2025-01-20