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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:

46

期数:

2024年08期

页码:

13-17

栏目:

临床研究

出版日期:

2024-12-20

文章信息/Info

Title:

Pathogen characteristics and drug resistance analysis of clinical infections in Fujian province

文章编号:

1002-2600(2024)08-0013-05

作者:

吴泉明; 陈东杰; 吴长生; 吴绍莲; 李瑶; 陈发林

福州大学附属省立医院,福州 350001

Author(s):

WU Quanming; CHEN Dongjie; WU Changsheng; WU Shaolian; LI Yao; CHEN Falin

Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian 350001, China

关键词:

病原菌分布;  抗菌药物;  耐药性;  细菌耐药监测

Keywords:

distribution of pathogenic bacteria;  antibacterial drugs;  drug resistance;  bacterial resistance surveillance

分类号:

R631

DOI:

10.20148/j.fmj.2024.08.004

文献标志码:

B

摘要:

目的 分析福建省2023年临床分离病原菌的分布特征及对常用抗菌药物的耐药性,为临床合理用药提供参考。方法 对全省60所医院按统一方案进行临床分离菌株抗菌药物敏感性试验,数据采用WHONET5.6软件进行统计分析。结果 剔除重复菌株后,革兰阳性菌55 995株(占30.3%),革兰阴性菌128 804株(占69.7%),主要来自于痰、尿、血等。革兰阳性菌检出率前3位为金黄色葡萄球菌、粪肠球菌、肺炎链球菌; 耐甲氧西林金黄色葡萄球菌(MRSA)检出率为27.3%,耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)检出率为73.9%; 未发现万古霉素、替考拉宁、利奈唑胺耐药葡萄球菌。革兰阴性菌检出率前3位为大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌; 大肠埃希菌对亚胺培南耐药率为1.1%,对头孢噻肟、左氧氟沙星耐药率分别为46.9%、45.9%; 肺炎克雷伯菌对亚胺培南耐药率为11.2%; 鲍曼不动杆菌对亚胺培南耐药率为50.5%,对其他抗菌药物耐药率多数超过40%; 铜绿假单胞菌对亚胺培南耐药率为17.0%,对其他大多数药物亦保持较高敏感性。结论 福建省临床感染的病原菌主要为大肠埃希菌、肺炎克雷伯菌和葡萄球菌等,部分病原菌耐药较为严重,临床应正确、合理使用抗菌药物。

Abstract:

Objective To explore the distribution characteristics of clinically isolated pathogens in Fujian Province and their resistance to commonly used antibiotics, and to provide reference for rational drug use in clinical practice.Methods Antimicrobial susceptibility tests on clinically isolated strains according to a unified protocol were conducted in sixty hospitals in the province, and data were analyzed using WHONET5.6 software.Results After removing duplicate strains, 55 995 Gram positive bacteria(30.3%)and 128 804 Gram negative bacteria(69.7%)were detected, mainly from sputum, urine, blood, etc.The top 3 Gram positive bacteria detection rates lied in staphylococcus aureus, enterococcus faecalis, streptococcus pneumoniae. The detection rates of MRSA and MRCNS were 27.3% and 73.9%, respectively.No vancomycin, teicoplanin, or linezolid resistant staphylococcus were found.The top 3 Gram negative bacteria detection rates lied in escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa.The resistance rate of escherichia coli to imipenem was 1.1%, while the resistance rates to cefotaxime and levofloxacin were 46.9% and 45.9%, respectively. The resistance rate of Klebsiella pneumoniae to imipenem was 11.2%; The resistance rate of acinetobacter baumannii to imipenem was 50.5%, and the resistance rate to other antibiotics was mostly over 40%.The resistance rate of pseudomonas aeruginosa to imipenem was 17.0%, and it also maintained high sensitivity to most other drugs.Conclusion The main pathogens causing clinical infections in Fujian province are Escherichia coli, klebsiella pneumoniae, and staphylococcus, etc.Some pathogens have severe drug resistance and should be used correctly and reasonably in clinical practice.

备注/Memo

备注/Memo:

通信作者:陈发林,Email:falinchen@126.com

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更新日期/Last Update: 2024-12-20