[1]余聪,陈名峰,丁昕,等.事件相关电位P3b成分在帕金森病认知障碍诊断中的应用[J].福建医药杂志,2024,46(07):1-4.[doi:10.20148/j.fmj.2024.07.001]
　YU Cong,CHEN Mingfeng,DING Xin,et al.Application of P3b component of event-related potentials in diagnosis of cognitive impairment in Parkinson's disease[J].FUJIAN MEDICAL JOURNAL,2024,46(07):1-4.[doi:10.20148/j.fmj.2024.07.001]
点击复制

事件相关电位P3b成分在帕金森病认知障碍诊断中的应用()
分享到：

《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期数:
2024年07期
页码:
1-4
栏目:
临床研究
出版日期:
2024-11-20

文章信息/Info

Title:
Application of P3b component of event-related potentials in diagnosis of cognitive impairment in Parkinson's disease
文章编号:
1002-2600(2024)07-0001-04
作者:
余聪; 陈名峰; 丁昕; 叶云珺; 陈培琼
福州大学附属省立医院神经内科,福州 350001
Author(s):
YU Cong;  CHEN Mingfeng;  DING Xin;  YE Yunjun;  CHEN Peiqiong
Department of Neurology, Affiliated Provincial Hospital of Fuzhou University, Fuzhou, Fujian 350001, China
关键词:
帕金森病;  认知障碍;  事件相关电位;  P3b
Keywords:
Parkinson's disease;  cognitive impairment;  event-related potential;  P3b
分类号:
R742.5
DOI:
10.20148/j.fmj.2024.07.001
文献标志码:
B
摘要:
目的 探讨事件相关电位P3b成分在帕金森病(PD)认知障碍诊断的应用价值。方法 比较PD组和健康对照组P3b指标的差异,评估P3b指标与PD组的临床资料及认知障碍的依存关系。结果 帕金森病痴呆(PDD)组的P3b潜伏期较帕金森病轻度认知障碍(PD-MCI)组延长(P<0.05),较健康对照组和帕金森病认知正常(PD-CN)组明显延长(P<0.01)。PD组的P3b潜伏期与蒙特利尔认知评估(MoCA)评分呈负相关(r=-0.506,P<0.01),视空间与执行力、延迟回忆对P3b潜伏期产生负向影响(t=-4.775,P<0.01; t=-2.186,P<0.05)。PD组的P3b潜伏期与年龄、Hoehn-Yahr分级、UPDRS-Ⅲ评分呈正相关(r=0.191,P<0.05; r=0.262,P<0.01; r=0.218,P<0.05),与受教育年限呈负相关(r=-0.340,P<0.01); PD组的P3b潜伏期与性别、帕金森病病程无明显的相关关系(r=0.041,P>0.05; r=0.084,P>0.05)。结论 认知损害越严重,P3b潜伏期越长,P3b潜伏期可以作为PD认知障碍的量化指标,对于早期识别PD认知障碍有意义。
Abstract:
Objective To explore the application value of P3b component of event-related potentials in the diagnosis of cognitive impairment of Parkinson's disease(PD)patients.Methods The difference in P3b indicators between PD group and healthy control group was compared, and the dependence relationship of P3b indicator on clinical data and cognitive impairment in the PD group was evaluated.Results The P3b latency of Parkinson's disease dementia(PDD)group was longer than that of PD mild cognitive impairment(PD-MCI)group(P<0.05), and significantly longer than that of the healthy control group and PD normal cognition(PD-CN)group(P<0.01).The P3b latency of the PD group was negatively correlated with the Montreal cognitive assessment(MoCA)score(r=-0.506, P<0.05), visuospatial and executive functions and delayed recall had negative impact on the P3b latency(t=-4.775, P<0.01; t=-2.186, P<0.05).The P3b latency in the PD group was positively correlated with age, Hoehn Yahr grading, and UPDRS-Ⅲ score(r=0.191,P<0.05; r=0.262,P<0.01; r=0.218,P<0.05), and negatively correlated with years of education(r=-0.340, P<0.01); The P3b latency in the PD group was not significantly correlated with gender and the course of Parkinson's disease(r=0.041,P>0.05; r=0.084,P>0.05).Conclusion The more severe the cognitive impairment, the longer the P3b latency.P3b latency can serve as a quantitative indicator of PD cognitive impairment, which is meaningful for early identification of PD cognitive impairment.

参考文献/References:

[1] TOLOSA E,GARRIDO A,SCHOLZ S W,et al.Challenges in the diagnosis of Parkinson's disease[J].Lancet Neurol,2021,20(5):385-397.
[2] BAIANO C,BARONE P,TROJANO L,et al.Prevalence and clinical aspects of mild cognitive impairment in Parkinson's disease: a meta-analysis[J].Movement Disorders, 2020, 35(19): 45-54.
[3] OLICHNEY J, XIA J, CHURCH K J,et al.Predictive power of cognitive biomarkers in neurodegenerative disease drug development: utility of the P300 event-related potential[J].Neural Plast,2022,11(8):2104880.
[4] 刘军.中国帕金森病的诊断标准(2016版)[J].中华神经科杂志,2016,49(4):268-271.
[5] 王丽娟,冯淑君,聂坤.中国帕金森病轻度认知障碍的诊断和治疗指南(2020版)[J].中国神经精神疾病杂志,2021,47(1):1-12.
[6] 中华医学会神经病学分会帕金森病及运动障碍学组,中国医师协会神经内科医师分会帕金森病及运动障碍学组,中华医学会神经病学分会神经心理与行为神经病学学组.帕金森病痴呆的诊断标准与治疗指南(第二版)[J].中华神经科杂志,2021,54(8):762-771.
[7] 上海市医学会脑电图与临床神经生理专科分会.事件相关电位的临床应用与操作规范上海专家共识[J].上海医学,2023(2):1-13.
[8] ROMAGNOLO A, ZIBETTI M, LENZI M, et al.Low frequency subthalamic stimulation and event-related potentials in Parkinson disease[J].Parkinsonism Relat Disord,2021,82:123-127.
[9] GAO L, GU L, SHU H, et al.The reduced left hippocampal volume related to the delayed P300 latency in amnestic mild cognitive impairment[J].Psychol Med,2021,51(12):2054-2062.
[10] TOKIC K, TITLIC M, BEGANOVIC-PETEOVIC A, et al.P300 wave changes in patients with Parkinson's disease[J].Med Arch, 2016,70(6):453-456.
[11] XU H, GU L, ZHANG S, et al.N200 and P300 component changes in Parkinson's disease: a meta-analysis[J].Neurol Sci, 2022,43(12):6719-6730.
[12] MELYNYTE S, WANG G Y, GRISKOVA-BULANOVA I.Gender effects on auditory P300: A systematic review[J].Int J Psychophysiol, 2018,133:55-65.
[13] YILMAZ F T, ZKAYNAK S S, BARCIN E.Contribution of auditory P300 test to the diagnosis of mild cognitive impairment in Parkinson's disease[J].Neurol Sci, 2017,38(12):2103-2109.
[14] PERGHER V, TOURNOY J, SCHOENMAKERS B, et al.P300, gray matter volume and individual characteristics correlates in healthy elderly[J].Front Aging Neurosci, 2019,3(11):104.
[15] NIE K, GAO Y, MEI M, et al.The clinical characteristics and cognitive features of mild cognitive impairment in Parkinson's disease and the analysis of relevant factors[J].J Clin Neurosci, 2019,63:142-148.
[16] SILVA LOPES M D, SOUZA MELO A D, NóBREGA A C.Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patients[J].Arq Neuropsiquiatr, 2014,72(4):296-300.

相似文献/References:

[1]章尤权,陈旭征,林瑶.松果菊苷对MPP+诱导的SH-SY5Y细胞氧化应激损伤的保护作用[J].福建医药杂志,2021,43(04):126.
　Zhang Youquan,Chen Xuzheng,LIN Yao.Protective effect of Echinoside on oxidative stress injury induced by MPP+ in SH-SY5Y cells[J].FUJIAN MEDICAL JOURNAL,2021,43(07):126.
[2]赵振华,潘楚锥,雷丽平,等.血浆外泌体中铁蛋白和转铁蛋白受体水平与帕金森病相关性研究[J].福建医药杂志,2023,45(03):1.
　ZHAO Zhenhua,PAN Chuzhui,LEI Liping,et al.The relationship between ferritin and transferrin receptor levels in plasma exosomes and Parkinson's disease[J].FUJIAN MEDICAL JOURNAL,2023,45(07):1.

备注/Memo

备注/Memo:
基金项目:福建省卫健委科技计划项目青年科研课题(2021QNA010 ); 福建医科大学启航基金一般项目(2019QH1190)
通信作者:陈名峰,Email: YcLunwen@outlook.com
更新日期/Last Update: 2024-11-20