[1]颜仁梁,李威.陈皮提取物对APP/PS-1双转基因阿尔茨海默病小鼠学习记忆功能的影响[J].福建医药杂志,2024,46(03):107-110.[doi:10.20148/j.fmj.2024.03.033]
　YAN Renliang,LI Wei.Effect of Citri Reticulatae Pericarpium extracts on the learning and memory function of APP/PS-1 double transgenic Alzheimers disease mice[J].FUJIAN MEDICAL JOURNAL,2024,46(03):107-110.[doi:10.20148/j.fmj.2024.03.033]
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陈皮提取物对APP/PS-1双转基因阿尔茨海默病小鼠学习记忆功能的影响()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期数:
2024年03期
页码:
107-110
栏目:
基础研究
出版日期:
2024-06-15

文章信息/Info

Title:
Effect of Citri Reticulatae Pericarpium extracts on the learning and memory function of APP/PS-1 double transgenic Alzheimers disease mice
文章编号:
1002-2600(2024)03-0107-04
作者:
颜仁梁; 李威
广东食品药品职业学院,广州 510000
Author(s):
YAN Renliang; LI Wei
Guangdong Food and Drug Vocational College, Guangzhou, Guangdong 510000, China
关键词:
陈皮提取物;  APP/PS-1双转基因AD小鼠;  Morris水迷宫实验;  避暗实验
Keywords:
Citri Reticulatae Pericarpium extracts;  APP/PS-1 double transgenic AD mice;  Morris water maze experiment;  dark avoidance experiment
分类号:
R9
DOI:
10.20148/j.fmj.2024.03.033
文献标志码:
B
摘要:
目的 探讨陈皮提取物对APP/PS-1双转基因阿尔茨海默病(AD)小鼠学习记忆功能的影响。方法 选用APP/PS-1双转基因AD小鼠16只,随机分为模型对照组和供试品组,8只/组,另取8只C57小鼠为正常对照组,正常对照组和模型对照组分别灌胃等量的生理盐水,供试品组灌胃陈皮提取物的生理盐水溶解液,灌胃体积为10 mL/kg,1次/d,连续18 d。第11天到第16天,进行Morris水迷宫的定位航行实验及空间探索实验。第17天到第18天,进行5 min避暗实验。结果 在Morris水迷宫实验中,与正常对照组比较,模型对照组定位航行第2天、第3天、第5天的潜伏期增加(P<0.05); 与模型对照组比较,供试品组第5天的潜伏期降低(P<0.05)。空间探索阶段,各组的目标象限路程百分比、时间百分比及站台穿越次数差异无统计学意义(P>0.05)。在避暗实验中各组的错误潜伏期、错误次数及错误率差异均无统计学意义(P>0.05)。结论 陈皮提取物对APP/PS-1双转基因AD小鼠的空间学习、记忆能力有一定的改善作用。
Abstract:
Objective To explore the effect of Citri Reticulatae Pericarpium extracts on the learning and memory ability of APP/PS-1 double transgenic Alzheimer's disease(AD)mice.Methods A total of 16 APP/PS-1 double transgenic AD mice were selected.They were randomly divided into model control group and test group(Citri Reticulatae Pericarpium extracts, 986 mg/kg), eight animals per group, another eight C57 mice were selected as the normal control group.Normal control group and model control group were respectively given the same amount of normal saline, the test group was given normal saline solution of Citri Reticulatae Pericarpium extracts.The volume of intragastric administration was 10 mL/kg once a day for 18 consecutive days.From day 11 to day 16, the positioning navigation experiment and space exploration experiment of Morris water maze were carried out.From the 17th to the 18th day, 5 min dark avoidance test was carried on.Results In the Morris water maze experiment, compared with the normal control group, the incubation period of the model control group was increased on the 2nd, 3rd and 5th day of positioning navigation(P<0.05).Compared with the model control group, the incubation period of the test group on day 5 was decreased(P<0.05).During the space exploration phase, there was no statistically significant difference(P>0.05)in the target quadrant distance percentage, time percentage, and platform crossing frequency among the groups.There were no significant differences in error latency, error times and error rate among all groups in the dark avoidance experiment(P>0.05).Conclusion Citri Reticulatae Pericarpium extracts can improve the spatial learning and memory ability of APP/PS-1 double transgenic AD mice.

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备注/Memo

备注/Memo:
基金项目:广东省医学科研基金项目(A2023416); 广东食品药品职业学院自然科学项目(2022ZR04)
更新日期/Last Update: 2024-06-15