[1]张秀安.非基因重组促细胞生成素依赖的血液透析影响因素分析[J].福建医药杂志,2022,44(05):18-21.
　ZHANG Xiu'an.Analysis of influencing factors of non-gene recombinant erythropoietin-dependent hemodialysis[J].FUJIAN MEDICAL JOURNAL,2022,44(05):18-21.
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非基因重组促细胞生成素依赖的血液透析影响因素分析()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期数:
2022年05期
页码:
18-21
栏目:
临床研究
出版日期:
2022-10-15

文章信息/Info

Title:
Analysis of influencing factors of non-gene recombinant erythropoietin-dependent hemodialysis
文章编号:
1002-2600（2022）05-0018-04
作者:
张秀安
福建医科大学附属漳州市医院肾内科（漳州 363000）
Author(s):
ZHANG Xiu'an
Department of Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, China
关键词:
血液透析; 贫血
Keywords:
hemodialysis;  anemia
分类号:
R692.5
文献标志码:
B
摘要:
目的 探讨非基因重组促红细胞生成素（r-HuEPO）依赖的血液透析的发病情况及影响因素。 方法 回顾性分析2017年8月1日至2020年7月31日在漳州市医院接受维持性血液透析治疗患者的临床资料，调查非r-HuEPO依赖的血液透析的发病情况及可能的影响因素。 结果 375例维持性血液透析患者中，非r-HuEPO依赖的透析发病率仅为6.4%。合并多囊肾病5例，获得性肾囊肿14例，单纯肾囊肿4例，恶性肿瘤1例。未发现乙型肝炎病毒感染与非r-HuEPO依赖的透析相关。多因素回归模型结果提示，性别和透析龄为非r-HuEPO依赖的透析发病的影响因素。 结论 非r-HuEPO依赖的透析发病率不高，囊肿性肾脏疾病可能是其潜在的病因，未发现乙型肝炎病毒感染与非r-HuEPO依赖的关联性。性别和透析龄为非r-HuEPO依赖的透析发病的影响因素。
Abstract:
Objective To investigate the incidence and influencing factors of non-gene recombinant erythropoietin (r-HuEPO)-dependent hemodialysis. Methods The clinical data of patients receiving maintenance hemodialysis in Zhangzhou Hospital from August 1, 2017 to July 31, 2020 were retrospectively analyzed to investigate the incidence of non-r-HuEPO-dependent hemodialysis and possible related factors.Results Among 375 MHD patients, the incidence of non- r-HuEPO-dependent dialysis was 6.4%. There were 5 cases of polycystic kidney disease, 14 cases of acquired Cystic kidney disease, 4 cases of simple Cystic kidney disease, and 1 case of malignant tumor. Hepatitis B virus infection was not associated with non- r-HuEPO-dependent dialysis. Gender and dialysis vintage might be the risk factors for the onset of non-r-HuEPO-dependent dialysis. Conclusion The incidence of non- r-HuEPO-dependent dialysis is low.Cystic kidney disease may be the potential cause of non- r-HuEPO-dependent dialysis. We do not find that hepatitis B virus infection is associated with non- r-HuEPO-dependent dialysis. Gender and dialysis vintage might be the risk factors for the onset of non- r-HuEPO-dependent dialysis.

参考文献/References:

[1] Fishbane S, Spinowitz B.Update on Anemia in ESRD and Earlier Stages of CKD: Core Curriculum 2018[J].Am J Kidney Dis，2018，71(3):423-435.
[2] Hasegawa T, Koiwa F, Akizawa T.Anemia in conventional hemodialysis: Finding the optimal treatment balance[J].Seminars in Dialysis，2018，31(6):599-606.
[3] Kuo C C, Lee C T, Chung C H, et al.Recombinant human erythropoietin independence in chronic hemodialysis patients: clinical features, iron homeostasis and erythropoiesis[J].Clin Nephrol，2005，63(2):92-97.
[4] Wan Q J, He Y C, Zhang W F, et al.Prevalence and related factors of the absence of anemia among Chinese chronic hemodialysis patients: a multicenter cross-sectional study[J].Int Urol Nephrol，2014，46 (8)：1651-1654.
[5] Verdalles U, Abad S, Vega A, et al.Factors related to the absence of anemia in hemodialysis patients[J].Blood Purif,2011,32(1):69-74.
[6] Sheqwara J, Alkhatib Y, Dabak V, et al.Idiopathic Erythrocytosis in Dialysis Patients: A Case Report and Literature Review[J].Am J Nephrol, 2013,37(4):333-338.
[7] Pisoni R L, Bragg-Gresham J L, Young E W, et al.Anemia management and outcomes from 12 countries in the dialysis and practice patterns study (DOPPS[BF])[BFQ][J].Am J Kidney Dis，2004,44(1):94-111.
[8] Shih H M, Wu C J, Lin S L.Physiology and pathophysiology of renal erythropoietin-producing cells[J].J Formos Med Assoc，2018,117(11):955-963.
[9] Kobayashi H, Davidoff O, Pujari-Palmer S, et al.EPO synthesis induced by HIF-PHD inhibition is dependent on myofibroblast transdifferentiation and colocalizes with non-injured nephron segments in murine kidney fibrosis[J].Acta Physiol (Oxf), 2022，235(4):e13826.
[10] Palop L.Anemia in dialysis: its relation to acquired cystic kidney disease and serum levels of erythropoietin[J].Am J Nephrol，1991,11:12-15.
[11] Lnnberg M, Garle M, Lnnberg L, et al.Patients with anaemia can shift from kidney to liver production of erythropoietin as shown by glycoform analysis[J].J Pharm Biomed Anal，2013,81-82: 187-192.
[12] de Seigneux S, Lundby A-K M，Berchtold L, et al.Increased synthesis of liver erythropoietin with CKD[J].J Am Soc Nephrol，2016, 27(8): 2265-2269.
[13] Annese T, Tamma R, Ruggieri S, et al.Erythropoietin in tumor angiogenesis[J].Exp Cell Res, 2019,15,374(2):266-273.
[14] Shirazian S, Starakiewicz P, Latcha S.Cancer Screening in End-Stage Kidney Disease[J].Adv Chronic Kidney Dis, 2021,28(5):502-508.
[15] Goembiewska E, Ciechanowski K.Repeat exit site infection in peritoneal dialysis patient with polycythemia vera- a case report[J].BMC Infect Dis,2021, 21(1):624.
[16] lger Y, Delik A.Paraneoplastic syndrome frequency and prognostic effect in hepatocellular carcinoma patients[J].Eur J Gastroenterol Hepatol, 2022, 34(7):769-773.
[17] Fox S, Griffin L, Robinson H D.Polycythemia Vera: Rapid Evidence Review[J].Am Fam Physician, 2021,103(11):680-687.

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更新日期/Last Update: 2022-10-15