[1]林洁,林杰祥,陈鸿驹,等.利用生物信息技术分析LncRNA SNHG11在子宫内膜癌中的临床意义[J].福建医药杂志,2022,44(03):29-32.
点击复制

利用生物信息技术分析LncRNA SNHG11在子宫内膜癌中的临床意义()
分享到:

《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期数:
2022年03期
页码:
29-32
栏目:
临床研究
出版日期:
2022-06-15

文章信息/Info

文章编号:
1002-2600(2022)03-0029-04
作者:
林洁林杰祥1陈鸿驹谢榕刘彬李桑2
福建医科大学附属肿瘤医院 福建省肿瘤医院妇科(福州 350014)
关键词:
子宫内膜癌 LncRNA SNHG11 预后 TCGA
分类号:
R737.33
文献标志码:
B
摘要:
目的 利用生物信息技术分析LncRNA SNHG11在子宫内膜癌中的表达及与预后的关系。方法 通过数据库数据分析子宫内膜癌组织和正常内膜中LncRNA SNHG11表达的差异及其与临床病理特征的关系,并进行生存分析及基因表达差异分析。结果 1)LncRNA SNHG11在子宫内膜癌组织的表达较正常内膜组织明显升高(P<0.001)。2)LncRNA SNHG11高表达患者整体生存与无复发生存期较低表达患者差异有统计学意义(P<0.05)。3)GO分析及KEGG分析表明LncRNA SNHG11生物学功能与激素的调控有关,且可能与神经活性配体-受体相互作用。结论 LncRNA SNHG11在子宫内膜癌组织中高表达并影响患者的预后,LncRNA SNHG11有望成为判读子宫内膜癌预后的分子标志物。

参考文献/References:

[1] Gao Y, Dai X, Lee A C, et al.Body Mass Index is Negatively Associated with Endometrial Cancer Stage, Regardless of Subtype and Menopausal Status[J].Journal of Cancer, 2018, 9(24):4756-4761.
[2] Brooks RA, Fleming GF, Lastra RR, et al.Current recommendations and recent progress in endometrial cancer[J].CA: A Cancer Journal for Clinicians, 2019,69(4):258-279.
[3] Peng WX, Koirala P, Mo YY.LncRNA-mediated regulation of cell signaling in cancer[J].Oncogene,2017,36(41):5661-5667.
[4] 戎晓东,陈炫光,蔡维洵,等.长链非编码RNA SNHG11对人肝癌细胞放疗抵抗作用的影响[J].广东医学,2019,40(13):1846-1850.
[5] Xu L, Huan L, Guo T, et al.LncRNA SNHG11 facilitates tumor metastasis by interacting with and stabilizing HIF-1α[J].Oncogene,2020,39(46):7005-7018.
[6] Xu W, Zhou G, Wang H, et al.Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer[J].International Journal of Cancer, 2019,146(10):2901-2912.
[7] Huang W, Dong S, Cha Y, et al.SNHG11 promotes cell proliferation in colorectal cancer by forming a positive regulatory loop with c-Myc[J].Biochemical and Biophysical Research Communications,2020, 527(4):985-992.
[8] Wu Q, Ma J, Wei J, Meng W, et al.lncRNA SNHG11 Promotes Gastric Cancer Progression by Activating the Wnt/β-Catenin Pathway and Oncogenic Autophagy[J].Science Direct,2020,29(3):1258-1278.
[9] Huang W, Huang F, Lei Z, et al.LncRNA SNHG11 Promotes Proliferation, Migration, Apoptosis, and Autophagy by Regulating hsa-miR-184/AGO2 in HCC[J].OncoTargets and Therapy,2020,1(13):413-421.
[10] Yu L, Zhang W, Wang P, et al.LncRNA SNHG11 aggravates cell proliferation and migration in triple-negative breast cancer via sponging miR-2355-5p and targeting CBX5[J].Exp Ther Med,2021,22(2):892-902.
[11] Liu S, Yang N, Wang L, et al.lncRNA SNHG11 promotes lung cancer cell proliferation and migration via activation of Wnt/β-catenin signaling pathway[J].Journal of Cellular Physiology,2020,235(10):7541-7553.

相似文献/References:

[1]杨丽英,杨直,杜薇,等.子宫内膜癌PPP2R5A及c-Myc表达与预后的临床关系[J].福建医药杂志,2023,45(05):1.
 YANG Liying,YANG Zhi,DU Wei,et al.Expression of PPP2R5A and c-Myc in endometrial cancer and clinical relationship with prognosis[J].FUJIAN MEDICAL JOURNAL,2023,45(03):1.

备注/Memo

备注/Memo:
1 福建医科大学省立临床医学院; 2 通信作者,Email:13559177333@163.com
更新日期/Last Update: 2022-06-15