[1]陈晓菁,朱素芹,李榕珊,等.卵泡期长效长方案不同促性腺激素启动剂量助孕效果的比较[J].福建医药杂志,2022,44(03):16-19.
　CHEN Xiaojing,ZHU Suqin,LI Rongshan,et al.Comparison of assisted reproductive outcome of different gonadotropin initiation dose groups in follicular phase long-acting long protocol[J].FUJIAN MEDICAL JOURNAL,2022,44(03):16-19.
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卵泡期长效长方案不同促性腺激素启动剂量助孕效果的比较()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期数:
2022年03期
页码:
16-19
栏目:
临床研究
出版日期:
2022-06-15

文章信息/Info

Title:
Comparison of assisted reproductive outcome of different gonadotropin initiation dose groups in follicular phase long-acting long protocol
文章编号:
1002-2600(2022)03-0016-04
作者:
陈晓菁; 朱素芹; 李榕珊; 姜雯雯1
福建省妇幼保健院 福建医科大学妇儿临床医学院(福州 350001)
Author(s):
CHEN Xiaojing;  ZHU Suqin;  LI Rongshan;  JIANG Wenwen
College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fujian Maternity and Child Health Hospital, Fuzhou,Fujian 350001, China
关键词:
卵泡期长效长方案;  低剂量促性腺激素;  临床结局
Keywords:
follicular phase long-acting long protocol;  low dose gonadotropin;  clinical outcomes
分类号:
R711.6
文献标志码:
B
摘要:
目的 探讨接受辅助生殖技术中卵泡期长效长方案超促排卵治疗的患者低剂量促性腺激素(gonadotropin,Gn)启动对助孕效果的影响。方法 收集于我中心接受助孕的1 289例患者临床资料,按照Gn启动剂量分为低剂量Gn启动组894例,常规Gn启动组395例,将两组患者的基本资料及临床结局进行统计分析。 结果 低剂量启动组的平均Gn起始剂量为(136.5±16.4)IU,常规剂量组为(207.0±27.1)IU,两组间Gn起始剂量差异有统计学意义(P<0.05)。低剂量组的Gn总量少于常规剂量组,两者差异有统计学意义(P<0.05)。 低剂量组的临床妊娠率高于常规剂量组,差异有统计学意义(P<0.05),而宫外孕率与早期流产率两组差异无统计学意义(P均>0.05)。中度卵巢过度刺激综合征(OHSS)发生率在低剂量组稍高于常规剂量组,而重度OHSS发生率在低剂量组稍低,但两者间差异无统计学意义(P均>0.05)。 结论 卵泡期长效长方案中采用低剂量Gn启动超促排卵可以获得更好的助孕效果,值得在临床进一步推广应用。
Abstract:
Objective To investigate the effect of low dose Gonadotropin(Gn)initiation on pregnancy outcome in patients undergoing ovarian hyperstimulation with follicular phase long-acting long protocol in assisted reproductive technology.Methods The clinical data of 1 289 patients who received assisted pregnancy in our center were collected and divided into low dose Gn initiation group(n=894)and conventional Gn initiation group(n=395)according to the dose of Gn initiation.The basic data and clinical outcomes of the two groups were statistically analyzed.Results The average Gn initial dose in the low-dose initiation group was(136.5±16.4)IU, and that in the conventional dose group was(207.0±27.1)IU.The difference in Gn initial dose between the two groups was statistically significant(P<0.05). The total amount of Gn in the low-dose group was lower than that in the conventional dose group, and the difference was statistically significant(P<0.05).The clinical pregnancy rate in the low dose group was higher than that in the conventional dose group, and the difference was statistically significant(P<0.05), while there was no significant difference in the ectopic pregnancy rate and early abortion rate between the two groups(P>0.05).The incidence of moderate ovarian hyperstimulation syndrome(OHSS)was slightly higher in the low-dose group than in the conventional dose group, while the incidence of severe OHSS was slightly lower in the low-dose group, but the difference was not statistically significant(P>0.05).Conclusion Low dose Gn in the follicular phase long-acting long protocol can achieve better clinical outcome and economic benefit, which is worth further promotion and exploration in clinical practice.

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备注/Memo

备注/Memo:
1 通信作者,Email:jiangww0574@163.com
更新日期/Last Update: 2022-06-15